scholarly journals Expression patterns of tight junction proteins in porcine major salivary glands: a comparison study with human and murine glands

2018 ◽  
Vol 233 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Xue-Ming Zhang ◽  
Yan Huang ◽  
Kuo Zhang ◽  
Ling-Han Qu ◽  
Xin Cong ◽  
...  
Keyword(s):  
Tight Junction ◽  
Salivary Glands ◽  
Expression Patterns ◽  
Comparison Study ◽  
Tight Junction Proteins ◽  
Major Salivary Glands ◽  
Junction Proteins

Expression Patterns of Tight Junction Proteins in Merkel Cell Carcinoma

2003 ◽  
pp. 223-226 ◽  
Author(s):  
Nikolas K. Haass ◽  
Pia Houdek ◽  
Ewa Wladykowski ◽  
Ingrid Moll ◽  
Johanna M. Brandner
Keyword(s):  
Tight Junction ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Expression Patterns ◽  
Merkel Cell ◽  
Tight Junction Proteins ◽  
Junction Proteins

scholarly journals Immunohistochemical Expression Patterns of Tight Junction Proteins, Pro-Apoptotic and Anti-Apoptotic Factors on Progression of Intestinal Mucositis of Onco-Hematological Patients under Epirubicin-Based Chemotherapy

2021 ◽  
Vol 11 (10) ◽  
pp. 4710
Author(s):  
Coralia Cotoraci ◽  
Alciona Sasu ◽  
Eftimie Miutescu ◽  
Dana Iovanescu ◽  
Sami Gharbia ◽  
...  
Keyword(s):  
Tight Junction ◽  
Caspase 3 ◽  
Expression Patterns ◽  
Intestinal Damage ◽  
Tight Junction Proteins ◽  
Hematological Patients ◽  
Chemotherapy Administration ◽  
Effector Caspase ◽  
Intestinal Mucositis ◽  
Junction Proteins

Chemotherapy and radiation are often accompanied by complications such as intestinal mucositis. The aim of this study was to assess by immunohistochemical assay the consequences of epirubicin-based therapy applied to onco-hematological patients, on the mucosal cells that undergo apoptosis and on the tight junction proteins, immediately before and after a short time of chemotherapy administration. We assessed the protein expression and distribution of the pro-apoptotic Bax, anti-apoptotic Bcl-2 and effector Caspase-3 as key proteins in apoptosis pathways and the changes in immunopositivity of Claudin-1 and ZO-1 tight junction proteins. Results show that the Bcl-2 family is involved in intestinal damage via Caspase-3 dependent apoptosis of epithelial cells. Additionally, the intestinal mucositis activates other injurious pathways through a dramatic drop in Claudin-1 and ZO-1 expressions, contributing for a while to a structural and functional integrity disruption of the intestinal epithelium.

Expression patterns of claudin family of tight-junction proteins in the mouse prostate

2007 ◽  
Vol 127 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Naoyuki Sakai ◽  
Hideki Chiba ◽  
Hiroki Fujita ◽  
Yushi Akashi ◽  
Makoto Osanai ◽  
...  
Keyword(s):  
Tight Junction ◽  
Expression Patterns ◽  
Tight Junction Proteins ◽  
Mouse Prostate ◽  
Junction Proteins

Tight junction proteins in HCC and metastatic liver tumours

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
Cs Páska ◽  
E Orbán ◽  
A Kiss ◽  
Zs Schaff ◽  
A Szijjártó ◽  
...  
Keyword(s):  
Tight Junction ◽  
Tight Junction Proteins ◽  
Liver Tumours ◽  
Metastatic Liver ◽  
Junction Proteins

Evidence that gene expression of ovarian follicular tight junction proteins is regulated in vivo and in vitro in cattle

2017 ◽  
Vol 95 (3) ◽  
pp. 1313 ◽  
Author(s):  
L. Zhang ◽  
L. F. Schütz ◽  
C. L. Robinson ◽  
M. L. Totty ◽  
L. J. Spicer
Keyword(s):  
Gene Expression ◽  
Tight Junction ◽  
Tight Junction Proteins ◽  
Junction Proteins

New insights in gut-liver axis in wild-type murine imiquimod-induced lupus

Lupus ◽  
2021 ◽  
Vol 30 (6) ◽  
pp. 926-936
Author(s):  
Georges Maalouly ◽  
Joelle Hajal ◽  
Charbel Noujeim ◽  
Michel Choueiry ◽  
Hussein Nassereddine ◽  
...  
Keyword(s):  
Tight Junction ◽  
Fecal Calprotectin ◽  
Liver Inflammation ◽  
Tight Junction Proteins ◽  
Wild Type ◽  
Imiquimod Cream ◽  
E Coli ◽  
Intestinal Pathology ◽  
Nfκb Pathway ◽  
Junction Proteins

Background Intestinal and hepatic manifestations of lupus seem to be underestimated in comparison to other major organ lesions. Although recent data point to gut-liver axis involvement in lupus, gut permeability dysfunction and liver inflammation need to be more investigated. Objective This study aims to assess fecal calprotectin, intestinal tight junction proteins and liver inflammation pathway in wild-type murine imiquimod- induced lupus. Methods C57BL/6 mice were topically treated on their right ears with 1.25 mg of 5% imiquimod cream, three times per week for six weeks. Fecal calprotectin was collected at day 0, 22 and 45. Renal, liver and intestinal pathology, as well as inflammatory markers, intestinal tight junction proteins, and E. coli protein in liver were assessed at sacrifice. Results At six weeks, lupus nephritis was confirmed on histopathology and NGAL and KIM-1 expression. Calprotectin rise started at day 22 and persists at day 45. Protein expression of Claudine, ZO-1 and occludin was significantly decreased. E. coli protein was significantly increased in liver with necro-inflammation and increased TLR4, TLR7, and pNFκB/NFκB liver expression. Conclusion This study is the first to demonstrate early fecal calprotectin increase and liver activation of TLR4- NFκB pathway in wild-type murine imiquimod-induced lupus.

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