scholarly journals Dorsal hippocampus not always necessary in a radial arm maze delayed win‐shift task

Hippocampus ◽  
2019 ◽  
Vol 30 (2) ◽  
pp. 121-129
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Shift Task

scholarly journals Dorsal Hippocampus Not Always Necessary in a Radial Arm Maze Delayed Win-shift Task

2018 ◽  
Author(s):  
Dylan Layfield ◽  
Nathan Sidell ◽  
Afnan Abdullahi ◽  
Ehren L. Newman
Keyword(s):  
Working Memory ◽  
Test Performance ◽  
Spatial Working Memory ◽  
Dorsal Hippocampus ◽  
Radial Arm Maze ◽  
Spatial Coding ◽  
Shift Task ◽  
Neural Underpinnings ◽  
Retention Intervals ◽  
Phosphate Buffered Saline

AbstractSpatial working memory is important for foraging and navigating the environment. However, its neural underpinnings remain poorly understood. The hippocampus, known for its spatial coding and involvement in spatial memory, is widely understood to be necessary for spatial working memory when retention intervals increase beyond seconds into minutes. Here, we describe new evidence that the dorsal hippocampus is not always necessary for spatial working memory for retention intervals of 8 minutes. Rats were trained to perform a delayed spatial win shift radial arm maze task (DSWS) with an 8-minute delay between study and test phases. We then tested whether bilateral inactivation of the dorsal hippocampus between the study and test phases impaired behavioral performance at test. Inactivation was achieved through a bilateral infusion of lidocaine. Performance following lidocaine was compared to control trials, in which, sterile phosphate buffered saline (PBS) was infused. Test performance did not differ between the lidocaine and PBS conditions, remaining high in each. To explore the possibility that this insensitivity to inactivation was a result of overtraining, a second cohort of animals received substantially less training prior to the infusions. In this second cohort, lidocaine infusions did significantly impair task performance. These data indicate that successful performance of a spatial win-shift task on the 8-arm maze need not always be hippocampally dependent.

Effects of Oxybutynin Hydrochloride on Working Memory in the Radial-Arm Maze

2000 ◽  
Author(s):  
Renee A. Countryman ◽  
Malinda A. Harris ◽  
Russell E. Morgan
Keyword(s):  
Working Memory ◽  
Radial Arm Maze ◽  
Oxybutynin Hydrochloride

GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus

2021 ◽  
Author(s):  
Cristina Rosell-Valle ◽  
Magdalena Martínez-Losa ◽  
Elisa Matas-Rico ◽  
Estela Castilla-Ortega ◽  
Emma Zambrana-Infantes ◽  
...  
Keyword(s):  
Dorsal Hippocampus ◽  
Coping Behaviors ◽  
Lpa1 Receptor ◽  
And Coping

scholarly journals Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 610
Author(s):  
Jessica C. Gaspar ◽  
Catherine Healy ◽  
Mehnaz I. Ferdousi ◽  
Michelle Roche ◽  
David P. Finn
Keyword(s):  
Spatial Memory ◽  
Cognitive Processing ◽  
Inflammatory Pain ◽  
Dorsal Hippocampus ◽  
Memory Function ◽  
Intraperitoneal Administration ◽  
Compensatory Mechanism ◽  
Chronic Inflammatory Pain ◽  
Pharmacological Blockade ◽  
Innate Anxiety

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPARα, PPARβ/δ and PPARγ. Studies suggest that the PPAR signalling system may modulate pain, anxiety and cognition. The aim of the present study was to investigate whether endogenous signalling via PPARs differentially modulates innate anxiety responses and mnemonic function in the presence and absence of inflammatory pain. We examined the effects of intraperitoneal administration of GW6471 (PPARα antagonist), GSK0660 (PPARβ/δ antagonist), GW9662 (PPARγ antagonist), and N-palmitoylethanolamide (PEA) on rat behaviour in the elevated plus maze (EPM), open field (OF), light-dark box (LDB), and novel object recognition (NOR) tests in the presence or absence of chronic inflammatory pain. Complete Freund’s Adjuvant (CFA)-injected rats exhibited impaired recognition and spatial mnemonic performance in the NOR test and pharmacological blockade of PPARα further impaired spatial memory in CFA-treated rats. N-oleoylethanolamide (OEA) levels were higher in the dorsal hippocampus in CFA-injected animals compared to their counterparts. The results suggest a modulatory effect of CFA-induced chronic inflammatory pain on cognitive processing, but not on innate anxiety-related responses. Increased OEA-PPARα signalling may act as a compensatory mechanism to preserve spatial memory function following CFA injection.

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