Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis

Hippocampus ◽  
2013 ◽  
Vol 23 (9) ◽  
pp. 797-811 ◽  
Author(s):  
Arnaud Tanti ◽  
Willy-Paul Westphal ◽  
Virginie Girault ◽  
Bruno Brizard ◽  
Severine Devers ◽  
...  
Keyword(s):  
Environmental Enrichment ◽  
Antidepressant Treatment ◽  
Hippocampal Neurogenesis ◽  
Specific Effects ◽  
Effects Of Stress

scholarly journals Short Daily Exposure to Environmental Enrichment, Fluoxetine, or Their Combination Reverses Deterioration of the Coat and Anhedonia Behaviors with Differential Effects on Hippocampal Neurogenesis in Chronically Stressed Mice

2021 ◽  
Vol 22 (20) ◽  
pp. 10976
Author(s):  
Gerardo Bernabé Ramírez-Rodríguez ◽  
Nelly Maritza Vega-Rivera ◽  
David Meneses-San Juan ◽  
Leonardo Ortiz-López ◽  
Erika Montserrat Estrada-Camarena ◽  
...  
Keyword(s):  
Pharmacological Treatment ◽  
Environmental Enrichment ◽  
Antidepressant Treatment ◽  
Antidepressant Drugs ◽  
Chronic Mild Stress ◽  
Living Environment ◽  
Hippocampal Neurogenesis ◽  
Mild Stress ◽  
Daily Exposure ◽  
Newborn Neurons

Depression is a neuropsychiatric disorder with a high impact on the worldwide population. To overcome depression, antidepressant drugs are the first line of treatment. However, pre-clinical studies have pointed out that antidepressants are not entirely efficacious and that the quality of the living environment after stress cessation may play a relevant role in increasing their efficacy. As it is unknown whether a short daily exposure to environmental enrichment during chronic stress and antidepressant treatment will be more effective than just the pharmacological treatment, this study analyzed the effects of fluoxetine, environmental enrichment, and their combination on depressive-associated behavior. Additionally, we investigated hippocampal neurogenesis in mice exposed to chronic mild stress. Our results indicate that fluoxetine reversed anhedonia. Besides, fluoxetine reversed the decrement of some events of the hippocampal neurogenic process caused by chronic mild stress. Conversely, short daily exposure to environmental enrichment changed the deterioration of the coat and anhedonia. Although, this environmental intervention did not produce significant changes in the neurogenic process affected by chronic mild stress, fluoxetine plus environmental enrichment showed similar effects to those caused by environmental enrichment to reverse depressive-like behaviors. Like fluoxetine, the combination reversed the declining number of Ki67, doublecortin, calretinin cells and mature newborn neurons. Finally, this study suggests that short daily exposure to environmental enrichment improves the effects of fluoxetine to reverse the deterioration of the coat and anhedonia in chronically stressed mice. In addition, the combination of fluoxetine with environmental enrichment produces more significant effects than those caused by fluoxetine alone on some events of the neurogenic process. Thus, environmental enrichment improves the benefits of pharmacological treatment by mechanisms that need to be clarified.

Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment

Hippocampus ◽  
2006 ◽  
Vol 16 (3) ◽  
pp. 239-249 ◽  
Author(s):  
Jennifer L. Warner-Schmidt ◽  
Ronald S. Duman
Keyword(s):  
Antidepressant Treatment ◽  
Hippocampal Neurogenesis ◽  
Effects Of Stress ◽  
Opposing Effects

scholarly journals Sex specific effects of pre-pubertal stress on hippocampal neurogenesis and behaviour

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Nichola Marie Brydges ◽  
Anna Moon ◽  
Lowenna Rule ◽  
Holly Watkin ◽  
Kerrie L. Thomas ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Specific Effects

scholarly journals Sex-Specific Effects of Stress on Mood-Related Gene Expression

2019 ◽  
Vol 5 (3) ◽  
pp. 162-176 ◽  
Author(s):  
Kelly Barko ◽  
William Paden ◽  
Kelly M. Cahill ◽  
Marianne L. Seney ◽  
Ryan W. Logan
Keyword(s):  
Gene Expression ◽  
Related Gene ◽  
Specific Effects ◽  
Effects Of Stress

Sex-specific effects of chronic antidepressant treatment in middle-aged rats: impact of citalopram on cognition and depressive-like behaviors

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 159 ◽  
Author(s):  
Ryoko Hiroi ◽  
Alicia M. Quihuis ◽  
Courtney N. Lavery ◽  
Steven J. Granger ◽  
Giulia Weyrich ◽  
...  
Keyword(s):  
Antidepressant Treatment ◽  
Aged Rats ◽  
Middle Aged ◽  
Specific Effects

scholarly journals Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?

2019 ◽  
Vol 20 (4) ◽  
pp. 949 ◽  
Author(s):  
David Herzog ◽  
Gregers Wegener ◽  
Klaus Lieb ◽  
Marianne Müller ◽  
Giulia Treccani
Keyword(s):  
Depressive Disorders ◽  
Treatment Guidelines ◽  
Antidepressant Treatment ◽  
Animal Experiments ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Specific Effects ◽  
Precise Understanding ◽  
Developed Nations ◽  
Gender Specific

Gender differences play a pivotal role in the pathophysiology and treatment of major depressive disorder. This is strongly supported by a mean 2:1 female-male ratio of depression consistently observed throughout studies in developed nations. Considering the urgent need to tailor individualized treatment strategies to fight depression more efficiently, a more precise understanding of gender-specific aspects in the pathophysiology and treatment of depressive disorders is fundamental. However, current treatment guidelines almost entirely neglect gender as a potentially relevant factor. Similarly, the vast majority of animal experiments analysing antidepressant treatment in rodent models exclusively uses male animals and does not consider gender-specific effects. Based on the growing interest in innovative and rapid-acting treatment approaches in depression, such as the administration of ketamine, its metabolites or electroconvulsive therapy, this review article summarizes the evidence supporting the importance of gender in modulating response to rapid acting antidepressant treatment. We provide an overview on the current state of knowledge and propose a framework for rodent experiments to ultimately decode gender-dependent differences in molecular and behavioural mechanisms involved in shaping treatment response.

Calmodulin activation is required for the enhancement of hippocampal neurogenesis following environmental enrichment

2009 ◽  
Vol 31 (7) ◽  
pp. 707-713 ◽  
Author(s):  
Le Zhong ◽  
Chong-Huai Yan ◽  
Cheng-Qiu Lu ◽  
Jian Xu ◽  
Hua Huang ◽  
...  
Keyword(s):  
Environmental Enrichment ◽  
Hippocampal Neurogenesis
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