scholarly journals Blockade of Indoleamine 2, 3-dioxygenase 1 ameliorates hippocampal neurogenesis and BOLD-fMRI signals in chronic stress precipitated depression

Aging ◽  
2021 ◽  
Author(s):  
Lei Gao ◽  
Tingting Gao ◽  
Ting Zeng ◽  
Peng Huang ◽  
Nai-Kei Wong ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Bold Fmri ◽  
Indoleamine 2

Sexual activity counteracts the suppressive effects of chronic stress on adult hippocampal neurogenesis and recognition memory

2013 ◽  
Vol 1538 ◽  
pp. 26-40 ◽  
Author(s):  
Jong-In Kim ◽  
Jae Won Lee ◽  
Young Ah Lee ◽  
Dong-Hun Lee ◽  
Nam Soo Han ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Sexual Activity ◽  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Sex-dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats

Hippocampus ◽  
2013 ◽  
Vol 23 (6) ◽  
pp. 476-487 ◽  
Author(s):  
Katharina M. Hillerer ◽  
Inga D. Neumann ◽  
Sebastien Couillard-Despres ◽  
Ludwig Aigner ◽  
David A. Slattery
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Stress Conditions

scholarly journals Elimination of Vesicular Zinc Alters the Behavioural and Neuroanatomical Effects of Social Defeat Stress in Mice

2018 ◽  
Author(s):  
Brendan B. McAllister ◽  
David K. Wright ◽  
Ryan C. Wortman ◽  
Sandy R. Shultz ◽  
Richard H. Dyck
Keyword(s):  
Corpus Callosum ◽  
Chronic Stress ◽  
Social Defeat ◽  
Volumetric Analysis ◽  
Hippocampal Neurogenesis ◽  
Wild Type ◽  
Enhanced Sensitivity ◽  
Y Maze ◽  
Genetic Deletion ◽  
Stress Susceptibility

ABSTRACTChronic stress can have deleterious effects on mental health, increasing the risk of developing depression or anxiety. But not all individuals are equally affected by stress; some are susceptible while others are more resilient. Understanding the mechanisms that lead to these differing outcomes has been a focus of considerable research. One unexplored mechanism is vesicular zinc – zinc that is released by neurons as a neuromodulator. We examined how chronic stress, induced by repeated social defeat, affects mice that lack vesicular zinc due to genetic deletion of zinc transporter 3 (ZnT3). These mice, unlike wild type mice, did not become socially avoidant of a novel conspecific, suggesting resilience to stress. However, they showed enhanced sensitivity to the potentiating effect of stress on cued fear memory. Thus, the contribution of vesicular zinc to stress susceptibility is not straightforward. Stress also increased anxiety-like behaviour but produced no deficits in a spatial Y-maze test. We found no evidence that microglial activation or hippocampal neurogenesis accounted for the differences in behavioural outcome. Volumetric analysis revealed that ZnT3 KO mice have larger corpus callosum and parietal cortex volumes, and that corpus callosum volume was decreased by stress in ZnT3 KO, but not wild type, mice.

Adult Hippocampal Neurogenesis Protects From Chronic Stress Effects in Mice

2020 ◽  
Vol 87 (9) ◽  
pp. S58-S59
Author(s):  
Christoph Anacker ◽  
Victor Luna ◽  
Ryan Shores ◽  
Gregory Stevens ◽  
Rene Hen
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Stress Effects

scholarly journals Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

2007 ◽  
Vol 13 (7) ◽  
pp. 717-728 ◽  
Author(s):  
I Goshen ◽  
T Kreisel ◽  
O Ben-Menachem-Zidon ◽  
T Licht ◽  
J Weidenfeld ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Interleukin 1 ◽  
Hippocampal Neurogenesis

scholarly journals Social Instability is an Effective Chronic Stress Paradigm for both Male and Female Mice

2019 ◽  
Author(s):  
Christine N. Yohn ◽  
Sandra A. Ashamalla ◽  
Leshya Bokka ◽  
Mark M. Gergues ◽  
Alexander Garino ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hpa Axis ◽  
Social Stress ◽  
Antidepressant Treatment ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Social Instability ◽  
Female Mice ◽  
Negative Valence ◽  
Males And Females

ABSTRACTDespite stress-associated disorders having a higher incidence rate in females, preclinical research mainly focuses on males. Chronic stress paradigms, such as chronic social defeat and chronic corticosterone administration, were mainly designed and validated in males and subsequent attempts to use these paradigms in females has demonstrated sex differences in the behavioral and HPA axis response to stress. Here, we developed a social stress paradigm, social instability stress (SIS), which exposes adult mice to unstable social hierarchies for 7 weeks. SIS effectively induces negative valence behaviors and hypothalamus-pituitary-adrenal (HPA) axis activation in both males and females. Importantly, while there were effects of estrous cycle on behavior, this variability did not impact the overall effects of SIS on behavior, suggesting estrous does not need to be tracked while utilizing SIS. Furthermore, the effects of SIS on negative valence behaviors were also reversed following chronic antidepressant treatment with fluoxetine (FLX) in both males and females. SIS also reduced adult hippocampal neurogenesis in female mice, while chronic FLX treatment increased adult hippocampal neurogenesis in both males and females. Overall, these data demonstrate that the SIS paradigm is an ethologically valid approach that effectively induces chronic stress in both adult male and adult female mice.

scholarly journals Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S487
Author(s):  
Seonghee Jung ◽  
Seongwon Choe ◽  
Hanwoong Woo ◽  
Hyeonjeong Jeong ◽  
Hyun-Kyu An ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Chronic Stress ◽  
Cognitive Deficits ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

Chronic stress targets adult hippocampal neurogenesis preferentially in the suprapyramidal blade of rat dorsal dentate gyrus

2017 ◽  
Vol 27 ◽  
pp. S1013-S1014
Author(s):  
N.D. Alves ◽  
P. Patrício ◽  
J.S. Correia ◽  
A. Mateus-Pinheiro ◽  
A.R. Machado-Santos ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Chronic Stress ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis
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