scholarly journals Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability

2019 ◽  
Vol 3 (11) ◽  
pp. 1435-1449 ◽  
Author(s):  
Daniel M. Chopyk ◽  
Johnasha D. Stuart ◽  
Matthew G. Zimmerman ◽  
Jing Wen ◽  
Sanjeev Gumber ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intestinal Permeability ◽  
Intestinal Crypt ◽  
Acetaminophen Intoxication

scholarly journals Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development ◽  
2011 ◽  
Vol 139 (3) ◽  
pp. 488-497 ◽  
Author(s):  
K. L. VanDussen ◽  
A. J. Carulli ◽  
T. M. Keeley ◽  
S. R. Patel ◽  
B. J. Puthoff ◽  
...  
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Intestinal Crypt ◽  
Proliferation And Differentiation ◽  
Crypt Base

scholarly journals Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes.

1989 ◽  
Vol 109 (5) ◽  
pp. 2139-2144 ◽  
Author(s):  
D R Burgess ◽  
W P Jiang ◽  
S Mamajiwalla ◽  
W Kinsey
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Tyrosine Kinase ◽  
Protein Tyrosine Kinase ◽  
Kinase Activity ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Tyrosine Kinase Activity ◽  
Intestinal Crypt

Growth and differentiation of stem cells is thought to be regulated by growth factors and responding protein tyrosine kinase activities. Comparing mitotic stem cells from the adult intestinal epithelium, isolated from the crypts of Lieberkuhn, with isolated differentiated absorbtive cells we find major differences in the levels of phosphotyrosine-containing proteins. Crypt stem cells possess two major phosphotyrosine-containing polypeptides of 36 and 17 kD which have greater than 15 times more phosphotyrosine than that present in the polypeptides of differentiated enterocytes. Tyrosine kinase activity and similar phosphotyrosine-containing proteins are associated with the Triton cytoskeleton. Moreover, crypt tyrosine kinase(s) is active in vitro in phosphorylating similar cytoskeleton-associated substrates. These results suggest that cytoskeleton-associated phosphotyrosine kinase(s) and their substrates may play a role in growth and differentiation of adult intestinal epithelial cells.

scholarly journals Selective irradiation of the vascular endothelium has no effect on the survival of murine intestinal crypt stem cells

2006 ◽  
Vol 103 (10) ◽  
pp. 3787-3792 ◽  
Author(s):  
B. W. Schuller ◽  
P. J. Binns ◽  
K. J. Riley ◽  
L. Ma ◽  
M. F. Hawthorne ◽  
...  
Keyword(s):  
Stem Cells ◽  
Vascular Endothelium ◽  
Intestinal Crypt ◽  
Selective Irradiation

302 Dynamic Regulation of Intestinal Crypt Base Columnar Stem Cells by Notch Signaling

2012 ◽  
Vol 142 (5) ◽  
pp. S-68
Author(s):  
Alexis J. Carulli ◽  
Gail B. Gifford ◽  
Wenli Liu ◽  
Linda C. Samuelson
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Dynamic Regulation ◽  
Intestinal Crypt ◽  
Crypt Base
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