scholarly journals Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development ◽  
2011 ◽  
Vol 139 (3) ◽  
pp. 488-497 ◽  
Author(s):  
K. L. VanDussen ◽  
A. J. Carulli ◽  
T. M. Keeley ◽  
S. R. Patel ◽  
B. J. Puthoff ◽  
...  
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Intestinal Crypt ◽  
Proliferation And Differentiation ◽  
Crypt Base

scholarly journals Notch signaling regulates proliferation and differentiation of the intestinal crypt base columnar (CBC) stem cell

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Linda C Samuelson ◽  
Kelli L VanDussen ◽  
Alexis J Carulli ◽  
Theresa M Keeley ◽  
Julie Smith
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Intestinal Crypt ◽  
Proliferation And Differentiation ◽  
Crypt Base

302 Dynamic Regulation of Intestinal Crypt Base Columnar Stem Cells by Notch Signaling

2012 ◽  
Vol 142 (5) ◽  
pp. S-68
Author(s):  
Alexis J. Carulli ◽  
Gail B. Gifford ◽  
Wenli Liu ◽  
Linda C. Samuelson
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Dynamic Regulation ◽  
Intestinal Crypt ◽  
Crypt Base

Mesenchymal stem cells regulate the proliferation and differentiation of neural stem cells through Notch signaling

2009 ◽  
Vol 33 (11) ◽  
pp. 1173-1179 ◽  
Author(s):  
Yang Wang ◽  
Wei Tu ◽  
Yuanlei Lou ◽  
An Xie ◽  
Xianliang Lai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Proliferation And Differentiation

Notch Signaling in Mammalian Intestinal Stem Cells: Determining Cell Fate and Maintaining Homeostasis

2019 ◽  
Vol 14 (7) ◽  
pp. 583-590 ◽  
Author(s):  
Shao-jie Liang ◽  
Xiang-guang Li ◽  
Xiu-qi Wang
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Cell Fate ◽  
Notch Signaling Pathway ◽  
Notch Receptor ◽  
Intestinal Stem Cells ◽  
Research Progress ◽  
Distinct Cell ◽  
Proliferation And Differentiation ◽  
Therapy Strategies

: The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pathway is induced via distinct cell-to-cell connections, which are activated through the binding of the Notch ligand on the surface of niche cells to the Notch receptor on ISCs. Numerous studies have shown the central importance of Notch signaling in the proliferation and differentiation of ISCs. Here, we summarize the latest research progress on the crucial functions of Notch signaling in maintaining homeostasis and determining the cell fate of ISCs. Furthermore, the challenges of Notch signaling in colon cancer therapy strategies are also discussed. Several important questions regarding Notch regulation of ISCs are proposed.

Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

Development ◽  
1988 ◽  
Vol 103 (4) ◽  
pp. 785-790 ◽  
Author(s):  
G.H. Schmidt ◽  
D.J. Winton ◽  
B.A. Ponder
Keyword(s):  
Stem Cells ◽  
Small Intestine ◽  
Single Cell ◽  
Progenitor Cell ◽  
Neonatal Period ◽  
Cell Renewal ◽  
Cellular Organization ◽  
Intestinal Crypt ◽  
Mouse Small Intestine ◽  
Crypt Base

We have previously shown that the epithelium of each adult intestinal crypt in chimaeric mice is derived from a single progenitor cell. Whether the crypts are monoclonal from the outset-that is, are formed by the proliferation of a single cell-or whether their formation is initiated by several cells was not known. Here we report that many crypts contain cells of both chimaeric genotypes in the neonatal period indicating a polyclonal origin at this stage of morphogenesis. The cellular organization of the early neonatal crypt is therefore different from that of the adult crypt, which includes a zone of ‘anchored’ stem cells above the crypt base. Within 2 weeks, however, the crypt progenitor cell and its descendants displace all other cells from the crypt and the crypt attains monoclonality. The distribution of enterocytes on chimaeric villi in the neonate shows a mottled pattern of mosaicism which is progressively replaced by coherent sheets of cells from the crypts, and within two weeks the orderly adult clonal pattern is established.

Application of Nanomaterials in Regulating the Fate of Adipose-derived Stem Cells

2021 ◽  
Vol 16 (1) ◽  
pp. 3-13
Author(s):  
Lang Wang ◽  
Yong Li ◽  
Maorui Zhang ◽  
Kui Huang ◽  
Shuanglin Peng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Research ◽  
Adult Stem Cells ◽  
Adipose Derived Stem Cells ◽  
Proliferation And Differentiation ◽  
Recent Developments ◽  
Good Biocompatibility ◽  
Regulatory Effects ◽  
New Treatment

Adipose-derived stem cells are adult stem cells which are easy to obtain and multi-potent. Stem-cell therapy has become a promising new treatment for many diseases, and plays an increasingly important role in the field of tissue repair, regeneration and reconstruction. The physicochemical properties of the extracellular microenvironment contribute to the regulation of the fate of stem cells. Nanomaterials have stable particle size, large specific surface area and good biocompatibility, which has led them being recognized as having broad application prospects in the field of biomedicine. In this paper, we review recent developments of nanomaterials in adipose-derived stem cell research. Taken together, the current literature indicates that nanomaterials can regulate the proliferation and differentiation of adipose-derived stem cells. However, the properties and regulatory effects of nanomaterials can vary widely depending on their composition. This review aims to provide a comprehensive guide for future stem-cell research on the use of nanomaterials.

Sign in / Sign up

Export Citation Format

Share Document