Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma

Hepatology ◽  
2012 ◽  
Vol 56 (3) ◽  
pp. 1004-1014 ◽  
Author(s):  
Juanjuan Shan ◽  
Junjie Shen ◽  
Limei Liu ◽  
Feng Xia ◽  
Chuan Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Human Hepatocellular Carcinoma ◽  
Insulin Like Growth Factor ◽  
Self Renewal

scholarly journals RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog

Theranostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 811-828 ◽  
Author(s):  
Junxia Cao ◽  
Min Zhao ◽  
Jian Liu ◽  
Xueying Zhang ◽  
Yujun Pei ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Hepatocellular Carcinoma ◽  
Self Renewal

scholarly journals Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells

Oncotarget ◽  
2016 ◽  
Vol 7 (32) ◽  
pp. 51349-51364 ◽  
Author(s):  
Xin Zhao ◽  
Xiaoliang Liu ◽  
Guanjun Wang ◽  
Xue Wen ◽  
Xiaoying Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Radiotherapy Resistance

scholarly journals Inhibition of β‑catenin protein expression by triptolide affects self-renewal of liver cancer stem cells

2015 ◽  
Vol 10 (2) ◽  
pp. 455 ◽  
Author(s):  
Jian-Bo Zhou ◽  
Gang Peng ◽  
Yu-Cheng Jia ◽  
Jun Li ◽  
Jia Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Inhibitory Concentration ◽  
The Self ◽  
Tripterygium Wilfordii ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Novel Agent

<p>The present study demonstrates the effects of triptolide, one of the constituents from Tripterygium wilfordii, on the self‑renewal capacity of human hepatocellular carcinoma. The investigation revealed that triptolide markedly prevented the proliferation of liver cancer stem cells (LCSCs). For the LCSCs the minimum inhibitory concentration of triptolide was 0.6 μM. There was a significant and obvious decrease in the capacity of LCSCs to form self-sphere. Furthermore, triptolide reduced the sphere-forming capacity of LCSCs along with inhibition of β‑catenin expression. However, the exposure of triptolide-treated cells to lithium chloride, an activator the Wnt/β-catenin signaling pathway, reversed the triptolide-induced inhibition of β-catenin expression and inhibited the self-renewal capacity. Therefore, triptolide effectively eradicates LCSCs through the inhibition of β-catenin protein and may act as a novel agent for the treatment of hepatocellular carcinoma.</p><p> </p>

scholarly journals Role of Insulin-like Growth Factor 1 Receptor Signaling in Stem Cell Stemness and Therapeutic Efficacy

2018 ◽  
Vol 27 (9) ◽  
pp. 1313-1319 ◽  
Author(s):  
Chiao-Fang Teng ◽  
Long-Bin Jeng ◽  
Woei-Cherng Shyu
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Growth Factor ◽  
Therapeutic Efficacy ◽  
Functional Markers ◽  
Insulin Like Growth Factor ◽  
Self Renewal ◽  
Placental Mesenchymal Stem Cells ◽  
Igf1r Signaling

Evidence has emerged that stem cells represent a promising therapeutic tool for tissue engineering and regenerative medicine. Thus, identifying functional markers for selecting stem cells capable of superior self-renewal and pluripotency (or multipotency) and maintaining stem cell identity under appropriate culture conditions are critical for guiding the use of stem cells toward clinical applications. Many investigations have implicated the insulin-like growth factor 1 receptor (IGF1R) signaling in maintenance of stem cell characteristics and enhancement of stem cell therapy efficacy. IGF1R-expressing stem cells display robust pluripotent or multipotent properties. In this review, we summarize the essential roles of IGF1R signaling in self-renewal, pluripotency (or multipotency), and therapeutic efficacy of stem cells, including human embryonic stem cells, neural stem cells, cardiac stem cells, bone marrow mesenchymal stem cells, placental mesenchymal stem cells, and dental pulp mesenchymal stem cells. Modifying IGF1R signaling may thus provide potential strategies for maintaining stem cell properties and improving stem-cell-based therapeutic applications.

scholarly journals Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma

2015 ◽  
Vol 63 (5) ◽  
pp. 1164-1172 ◽  
Author(s):  
Kouki Nio ◽  
Taro Yamashita ◽  
Hikari Okada ◽  
Mitsumasa Kondo ◽  
Takehiro Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Chromatin Remodeling ◽  
Human Hepatocellular Carcinoma ◽  
Liver Cancer Stem Cells

scholarly journals A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma

Hepatology ◽  
2010 ◽  
Vol 52 (5) ◽  
pp. 1702-1712 ◽  
Author(s):  
Chunxian Zeng ◽  
Ruizhi Wang ◽  
Daochuan Li ◽  
Xue-Jia Lin ◽  
Qing-Kun Wei ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Human Hepatocellular Carcinoma ◽  
Insulin Like Growth Factor
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