scholarly journals RACK1 Promotes Self-Renewal and Chemoresistance of Cancer Stem Cells in Human Hepatocellular Carcinoma through Stabilizing Nanog

Theranostics ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 811-828 ◽  
Author(s):  
Junxia Cao ◽  
Min Zhao ◽  
Jian Liu ◽  
Xueying Zhang ◽  
Yujun Pei ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Hepatocellular Carcinoma ◽  
Self Renewal

scholarly journals Inhibition of β‑catenin protein expression by triptolide affects self-renewal of liver cancer stem cells

2015 ◽  
Vol 10 (2) ◽  
pp. 455 ◽  
Author(s):  
Jian-Bo Zhou ◽  
Gang Peng ◽  
Yu-Cheng Jia ◽  
Jun Li ◽  
Jia Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Inhibitory Concentration ◽  
The Self ◽  
Tripterygium Wilfordii ◽  
Self Renewal ◽  
Liver Cancer Stem Cells ◽  
Novel Agent

<p>The present study demonstrates the effects of triptolide, one of the constituents from Tripterygium wilfordii, on the self‑renewal capacity of human hepatocellular carcinoma. The investigation revealed that triptolide markedly prevented the proliferation of liver cancer stem cells (LCSCs). For the LCSCs the minimum inhibitory concentration of triptolide was 0.6 μM. There was a significant and obvious decrease in the capacity of LCSCs to form self-sphere. Furthermore, triptolide reduced the sphere-forming capacity of LCSCs along with inhibition of β‑catenin expression. However, the exposure of triptolide-treated cells to lithium chloride, an activator the Wnt/β-catenin signaling pathway, reversed the triptolide-induced inhibition of β-catenin expression and inhibited the self-renewal capacity. Therefore, triptolide effectively eradicates LCSCs through the inhibition of β-catenin protein and may act as a novel agent for the treatment of hepatocellular carcinoma.</p><p> </p>

scholarly journals Defeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma

2015 ◽  
Vol 63 (5) ◽  
pp. 1164-1172 ◽  
Author(s):  
Kouki Nio ◽  
Taro Yamashita ◽  
Hikari Okada ◽  
Mitsumasa Kondo ◽  
Takehiro Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Chromatin Remodeling ◽  
Human Hepatocellular Carcinoma ◽  
Liver Cancer Stem Cells

scholarly journals Sox9 regulates self-renewal and tumorigenicity by promoting symmetrical cell division of cancer stem cells in hepatocellular carcinoma

Hepatology ◽  
2016 ◽  
Vol 64 (1) ◽  
pp. 117-129 ◽  
Author(s):  
Chungang Liu ◽  
Limei Liu ◽  
Xuejiao Chen ◽  
Jiamin Cheng ◽  
Heng Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cell Division ◽  
Cancer Stem Cells ◽  
Self Renewal ◽  
Symmetrical Cell

scholarly journals Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1

2017 ◽  
Vol 6 (11) ◽  
pp. 2531-2540 ◽  
Author(s):  
Takayuki Kawai ◽  
Kentaro Yasuchika ◽  
Takamichi Ishii ◽  
Hokahiro Katayama ◽  
Elena Yukie Yoshitoshi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Human Hepatocellular Carcinoma ◽  
Keratin 19
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