scholarly journals Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells

Oncotarget ◽  
2016 ◽  
Vol 7 (32) ◽  
pp. 51349-51364 ◽  
Author(s):  
Xin Zhao ◽  
Xiaoliang Liu ◽  
Guanjun Wang ◽  
Xue Wen ◽  
Xiaoying Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Radiotherapy Resistance

scholarly journals The Roles of Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 in Cancer and Cancer Stem Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Junguo Cao ◽  
Qingchun Mu ◽  
Haiyan Huang
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Wide Range ◽  
Mrna Binding Protein ◽  
Mrna Binding

RNA-binding proteins (RBPs) mediate the localization, stability, and translation of the target transcripts and fine-tune the physiological functions of the proteins encoded. The insulin-like growth factor (IGF) 2 mRNA-binding protein (IGF2BP, IMP) family comprises three RBPs, IGF2BP1, IGF2BP2, and IGF2BP3, capable of associating with IGF2 and other transcripts and mediating their processing. IGF2BP2 represents the least understood member of this family of RBPs; however, it has been reported to participate in a wide range of physiological processes, such as embryonic development, neuronal differentiation, and metabolism. Its dysregulation is associated with insulin resistance, diabetes, and carcinogenesis and may potentially be a powerful biomarker and candidate target for relevant diseases. This review summarizes the structural features, regulation, and functions of IGF2BP2 and their association with cancer and cancer stem cells.

scholarly journals Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86459 ◽  
Author(s):  
Akiko Murakami ◽  
Fumiyuki Takahashi ◽  
Fariz Nurwidya ◽  
Isao Kobayashi ◽  
Kunihiko Minakata ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Insulin Like Growth Factor ◽  
Lung Cancer Stem Cells

scholarly journals Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

Cell Cycle ◽  
2011 ◽  
Vol 10 (14) ◽  
pp. 2331-2338 ◽  
Author(s):  
Lori S. Hart ◽  
Nathan G. Dolloff ◽  
David T. Dicker ◽  
Constantinos Koumenis ◽  
James G. Christensen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Human Colon ◽  
Insulin Like Growth Factor ◽  
Human Colon Cancer ◽  
Colon Cancer Stem Cells
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