scholarly journals Longitudinal changes in regional cerebral blood flow in late middle‐aged and older adults with treated and untreated obstructive sleep apnea

2021 ◽  
Author(s):  
Francis L'Heureux ◽  
Andrée‐Ann Baril ◽  
Katia Gagnon ◽  
Jean‐Paul Soucy ◽  
Chantal Lafond ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Middle Aged ◽  
Longitudinal Changes ◽  
Obstructive Sleep

scholarly journals Regional Cerebral Blood Flow during Wakeful Rest in Older Subjects with Mild to Severe Obstructive Sleep Apnea

SLEEP ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1439-1449 ◽  
Author(s):  
Andrée-Ann Baril ◽  
Katia Gagnon ◽  
Caroline Arbour ◽  
Jean-Paul Soucy ◽  
Jacques Montplaisir ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Regional Cerebral Blood Flow ◽  
Severe Obstructive Sleep Apnea ◽  
Regional Cerebral Blood ◽  
Obstructive Sleep ◽  
Older Subjects

Altered regional cerebral blood flow in obstructive sleep apnea is associated with sleep fragmentation and oxygen desaturation

2021 ◽  
pp. 0271678X2110121
Author(s):  
Lirong Yan ◽  
Hea Ree Park ◽  
Eric J. Kezirian ◽  
Soonhyun Yook ◽  
Jae-Hun Kim ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Default Mode Network ◽  
Cerebral Perfusion ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Network ◽  
Obstructive Sleep

Altered cerebral perfusion has been reported in obstructive sleep apnea (OSA). Using dynamic susceptibility contrast MRI, we compared cerebral perfusion between male OSA patients and male healthy reference subjects and assessed correlations of perfusion abnormalities of OSA patients with sleep parameters and neuropsychological deficits at 3 T MRI, polysomnography and neuropsychological tests in 68 patients with OSA and 21 reference subjects. We found lower global and regional cerebral blood flow and cerebral blood volume, localized mainly in bilateral parietal and prefrontal cortices, as well as multiple focal cortical and deep structures related to the default mode network and attention network. In the correlation analysis between regional hypoperfusion and parameters of polysomnography, different patterns of regional hypoperfusion were distinctively associated with parameters of intermittent hypoxia and sleep fragmentation, which involved mainly parietal and orbitofrontal cortices, respectively. There was no association between brain perfusion and cognition in OSA patients in areas where significant association was observed in reference subjects, largely overlapping with nodes of the default mode network and attention network. Our results suggest that impaired cerebral perfusion in important areas of functional networks could be an important pathomechanism of neurocognitive deficits in OSA.

scholarly journals Regional cerebral blood flow alterations in obstructive sleep apnea

2013 ◽  
Vol 555 ◽  
pp. 159-164 ◽  
Author(s):  
Santosh K. Yadav ◽  
Rajesh Kumar ◽  
Paul M. Macey ◽  
Heidi L. Richardson ◽  
Danny J.J. Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Obstructive Sleep

White matter longitudinal changes in middle-aged and older adults with obstructive sleep apnea

2019 ◽  
Vol 64 ◽  
pp. S245
Author(s):  
M.-E. Martineau-Dussault ◽  
A.-A. Baril ◽  
E. Sanchez ◽  
S. Chami ◽  
J. Legault ◽  
...  
Keyword(s):  
Older Adults ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
White Matter ◽  
Middle Aged ◽  
Longitudinal Changes ◽  
Obstructive Sleep

scholarly journals Obstructive sleep apnea during REM sleep and daytime cerebral functioning: A regional cerebral blood flow study using high-resolution SPECT

2018 ◽  
Vol 40 (6) ◽  
pp. 1230-1241 ◽  
Author(s):  
Andrée-Ann Baril ◽  
Katia Gagnon ◽  
Pauline Brayet ◽  
Jacques Montplaisir ◽  
Julie Carrier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Rem Sleep ◽  
Regional Cerebral Blood Flow ◽  
Apnea Hypopnea Index ◽  
Brain Health ◽  
Regional Cerebral Blood ◽  
Respiratory Events ◽  
Obstructive Sleep

Obstructive sleep apnea (OSA) predominantly during rapid eye movement (REM) sleep may have impacts on brain health, even in milder OSA cases. Here, we evaluated whether REM sleep OSA is associated with abnormal daytime cerebral functioning using high-resolution single-photon emission computed tomography (SPECT). We tested 96 subjects (25 F, age: 65.2 ± 6.4) with a wide range of OSA severity from no OSA to severe OSA (apnea–hypopnea index: 0–97 events/h). More respiratory events during REM sleep were associated with reduced daytime regional cerebral blood flow (rCBF) in the bilateral ventromedial prefrontal cortex and in the right insula extending to the frontal cortex. More respiratory events during non-REM (NREM) sleep were associated with reduced daytime rCBF in the left sensorimotor and temporal cortex. In subjects with a lower overall OSA severity (apnea–hypopnea index<15), more respiratory events during REM sleep were also associated with reduced daytime rCBF in the insula and extending to the frontal cortex. Respiratory events that characterized OSA during NREM versus REM sleep are associated with distinct patterns of daytime cerebral perfusion. REM sleep OSA could be more detrimental to brain health, as evidenced by reduced daytime rCBF in milder forms of OSA.

scholarly journals Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome

SLEEP ◽  
2016 ◽  
Vol 39 (1) ◽  
pp. 209-216 ◽  
Author(s):  
David R. Busch ◽  
Jennifer M. Lynch ◽  
Madeline E. Winters ◽  
Ann L. McCarthy ◽  
John J. Newland ◽  
...  
Keyword(s):  
Blood Flow ◽  
Obstructive Sleep Apnea ◽  
Cerebral Blood Flow ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Blood Flow Response ◽  
Flow Response ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Intima-Media Thickness and Regional Cerebral Blood Flow in Older Adults

Stroke ◽  
2010 ◽  
Vol 41 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Jitka Sojkova ◽  
Samer S. Najjar ◽  
Lori L. Beason-Held ◽  
E. Jeffrey Metter ◽  
Christos Davatzikos ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Intima Media Thickness ◽  
Regional Cerebral Blood ◽  
Media Thickness
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