scholarly journals Intima-Media Thickness and Regional Cerebral Blood Flow in Older Adults

Stroke ◽  
2010 ◽  
Vol 41 (2) ◽  
pp. 273-279 ◽  
Author(s):  
Jitka Sojkova ◽  
Samer S. Najjar ◽  
Lori L. Beason-Held ◽  
E. Jeffrey Metter ◽  
Christos Davatzikos ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Intima Media Thickness ◽  
Regional Cerebral Blood ◽  
Media Thickness

Aging and Recognition Memory: Changes in Regional Cerebral Blood Flow Associated with Components of Reaction Time Distributions

1999 ◽  
Vol 11 (5) ◽  
pp. 511-520 ◽  
Author(s):  
David J. Madden ◽  
Lawrence R. Gottlob ◽  
Laura L. Denny ◽  
Timothy G. Turkington ◽  
James M. Provenzale ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Young Adults ◽  
Cerebral Blood Flow ◽  
Reaction Time ◽  
Task Performance ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Age Related ◽  
The Mean

We used H215O positron emission tomography (PET) to measure age-related changes in regional cerebral blood flow (rCBF) during a verbal recognition memory task. Twelve young adults (20 to 29 years) and 12 older adults (62 to 79 years) participated. Separate PET scans were conducted during Encoding, Baseline, and Retrieval conditions. Each of the conditions involved viewing a series of 64 words and making a two-choice response manually. The complete reaction time (RT) distributions in each task condition were characterized in terms of an ex-Gaussian model (convolution of exponential and Gaussian functions). Parameter estimates were obtained for the mean of the exponential component (τ), representing a task-specific decision process and the mean of the Gaussian component (μ), representing residual sensory coding and response processes. Independently of age group, both μ and τ were higher in the Encoding and Retrieval conditions than in the Baseline condition, and τ was higher during Retrieval than during Encoding. Age-related slowing in task performance was evident primarily in μ. For young adults, rCBF activation in the right prefrontal cortex, in the Retrieval condition, was correlated positively with μ but not with τ. For older adults, rCBF changes (both increases and decreases) in several cortical regions were correlated with both μ and τ. The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance.

scholarly journals Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults

2021 ◽  
Author(s):  
Kelsey R. Thomas ◽  
Alexandra J. Weigand ◽  
Isabel H. Cota ◽  
Emily C. Edmonds ◽  
Christina E. Wierenga ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Blood Glucose ◽  
Regional Cerebral Blood Flow ◽  
Word List ◽  
Regional Cerebral Blood ◽  
Glucose Levels ◽  
Main Effect ◽  
Intrusion Errors

AbstractRegional cerebral blood flow (CBF) has a complex relationship with cognitive functioning such that cognitively unimpaired individuals at risk for Alzheimer’s disease (AD) may show regional hyperperfusion, while those with cognitive impairment typically show hypoperfusion. Diabetes and word-list intrusion errors are both linked to greater risk of cognitive decline and dementia. Our study examined associations between fasting blood glucose, word-list intrusion errors, and regional CBF. 113 cognitively unimpaired older adults had arterial spin labeling MRI to measure CBF in a priori AD vulnerable regions: medial temporal lobe (MTL), inferior parietal lobe (IPL), precuneus, medial orbitofrontal cortex (mOFC), and pericalcarine (control region). Hierarchical linear regressions, adjusting for demographics, vascular risk, and reference CBF region, examined the main effect of blood glucose on regional CBF as well as whether intrusions moderated this relationship. Higher glucose was associated with higher CBF in the precuneus (β = .134, 95% CI = .007 to .261, p = .039), IPL (β = .173, 95% CI = .072 to .276, p = .001), and mOFC (β = .182, 95% CI = .047 to .320, p = .009). There was no main effect of intrusions on CBF across regions. However, the glucose x intrusions interaction was significant such that having higher glucose levels and more intrusion errors was associated with reduced CBF in the MTL (β = -.186, 95% CI = -.334 to -.040, p = .013) and precuneus (β = -.146, 95% CI = -.273 to -.022, p = .022). These findings may reflect early neurovascular dysregulation, whereby higher CBF is needed to maintain unimpaired cognition in individuals with higher glucose levels. However, lower regional CBF in unimpaired participants with both higher glucose and more intrusions suggests a failure in this early compensatory mechanism that may signal a decrease in neural activity in AD vulnerable regions.

scholarly journals Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes

2018 ◽  
Vol 10 ◽  
Author(s):  
Katherine J. Bangen ◽  
Madeleine L. Werhane ◽  
Alexandra J. Weigand ◽  
Emily C. Edmonds ◽  
Lisa Delano-Wood ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood

Regional cerebral blood flow in schizophrenia while performing an attention task

2014 ◽  
Author(s):  
Scott Harcourt ◽  
Daniel G. Amen ◽  
Kristin C. Willeumier ◽  
Charles J. Golden
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Attention Task
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