scholarly journals Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals

2009 ◽  
Vol 30 (10) ◽  
pp. 3406-3416 ◽  
Author(s):  
Tilo Kircher ◽  
Axel Krug ◽  
Valentin Markov ◽  
Carin Whitney ◽  
Sören Krach ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Speech Production ◽  
Verbal Fluency ◽  
Brain Activation ◽  
Healthy Individuals ◽  
Neuregulin 1 ◽  
Verbal Fluency Task ◽  
Risk Gene ◽  
Impaired Speech ◽  
Fluency Task

Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression

2016 ◽  
Vol 74 (2) ◽  
pp. 69-77 ◽  
Author(s):  
Masahiro Takamura ◽  
Yasumasa Okamoto ◽  
Go Okada ◽  
Shigeru Toki ◽  
Tetsuya Yamamoto ◽  
...  
Keyword(s):  
Major Depression ◽  
Verbal Fluency ◽  
Brain Activation ◽  
Verbal Fluency Task ◽  
Semantic Verbal Fluency ◽  
Fluency Task

scholarly journals Prefrontal Functional Connectivity During the Verbal Fluency Task in Patients With Major Depressive Disorder: A Functional Near-Infrared Spectroscopy Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Suh-Yeon Dong ◽  
JongKwan Choi ◽  
Yeonsoo Park ◽  
Seung Yeon Baik ◽  
Minjee Jung ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Infrared Spectroscopy ◽  
Functional Connectivity ◽  
Verbal Fluency ◽  
Near Infrared ◽  
Healthy Individuals ◽  
Major Depressive ◽  
Functional Near Infrared Spectroscopy ◽  
Verbal Fluency Task ◽  
Fluency Task

Deviations in activation patterns and functional connectivity have been observed in patients with major depressive disorder (MDD) with prefrontal hemodynamics of patients compared with healthy individuals. The graph-theoretical approach provides useful network metrics for evaluating functional connectivity. The evaluation of functional connectivity during a cognitive task can be used to explain the neurocognitive mechanism underlying the cognitive impairments caused by depression. Overall, 31 patients with MDD and 43 healthy individuals completed a verbal fluency task (VFT) while wearing a head-mounted functional near-infrared spectroscopy (fNIRS) devices. Hemodynamics and functional connectivity across eight prefrontal subregions in the two groups were analyzed and compared. We observed a reduction in prefrontal activation and weaker overall and interhemispheric subregion-wise correlations in the patient group compared with corresponding values in the control group. Moreover, efficiency, the network measure related to the effectiveness of information transfer, showed a significant between-group difference [t (71.64) = 3.66, corrected p < 0.001] along with a strong negative correlation with depression severity (rho = −0.30, p = 0.009). The patterns of prefrontal functional connectivity differed significantly between the patient and control groups during the VFT. Network measures can quantitatively characterize the reduction in functional connectivity caused by depression. The efficiency of the functional network may play an important role in the understanding of depressive symptoms.

scholarly journals A Verbal Fluency Task‐Based Brain Activation fMRI Study in Patients with Crohn's Disease in Remission

2019 ◽  
Vol 29 (5) ◽  
pp. 630-639 ◽  
Author(s):  
Veena A. Nair ◽  
Keith Dodd ◽  
Shruti Rajan ◽  
Anu Santhanubosu ◽  
Poonam Beniwal‐Patel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Verbal Fluency ◽  
Brain Activation ◽  
Verbal Fluency Task ◽  
Fmri Study ◽  
Fluency Task

Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals

NeuroImage ◽  
2008 ◽  
Vol 42 (4) ◽  
pp. 1569-1576 ◽  
Author(s):  
Axel Krug ◽  
Valentin Markov ◽  
Thomas Eggermann ◽  
Sören Krach ◽  
Klaus Zerres ◽  
...  
Keyword(s):  
Working Memory ◽  
Genetic Variation ◽  
Memory Task ◽  
Brain Activation ◽  
Healthy Individuals ◽  
Risk Gene ◽  
Frontal Brain

scholarly journals Prefrontal Cortex Activation During Verbal Fluency Task and Tower of London Task in Schizophrenia and Major Depressive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Yilei Xiang ◽  
Yuan Li ◽  
Chang Shu ◽  
Zhongchun Liu ◽  
Huiling Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Verbal Fluency ◽  
Brain Activation ◽  
Cognitive Tasks ◽  
Hemodynamic Changes ◽  
Major Depressive ◽  
Verbal Fluency Task ◽  
Patient Groups ◽  
Fluency Task

Background: Cognitive dysfunction is a common clinical feature of mental disorders. A number of functional near-infrared spectroscopy (fNIRS) studies have shown reduced prefrontal activation during the verbal fluency task (VFT) in schizophrenia (SZ) and major depressive disorder (MDD). However, no studies have examined and compared the brain activation patterns during the Tower of London (TOL), which is another classic, high-sensitivity executive function testing tool, in these two serious mental disorders. This study aimed to assess the characteristics of brain activation during the two different cognitive tasks in SZ and MDD patients.Methods: This study recruited 30 patients with SZ, 30 patients with MDD, and 30 demographically matched healthy controls (HCs). The hemodynamic changes of the prefrontal cortex (PFC) were measured using 32-channel fNIRS during performance of the TOL task and VFT task.Results: SZ patients showed poorer VFT performance than MDD patients and HCs, and the two patient groups showed poorer TOL performance than HCs. Compared to HCs, both of the patient groups exhibited a significant decreased activation in the extensive PFC. Particularly in certain channels in the dorsolateral PFC (DLPFC), SZ patients exhibited significantly decreased hemodynamic changes than the MDD patients.Conclusions: Patients with SZ and MDD have different levels of impairment in different cognitive domains and different patterns of brain activation during the two cognitive tasks. Further research is needed to determine the use of fNIRS for clinical evaluation and diagnosis.

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