β8 integrin is essential for neuroblast migration in the rostral migratory stream

Glia ◽  
2011 ◽  
Vol 59 (11) ◽  
pp. 1579-1587 ◽  
Author(s):  
Aaron K. Mobley ◽  
Joseph H. McCarty
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

Astrocytic and Vascular Scaffolding for Neuroblast Migration in the Rostral Migratory Stream

2014 ◽  
Vol 11 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Marcela Marton.cikova ◽  
Kamila Fabianova ◽  
Andrea Schreiberova ◽  
Juraj Bla.sko ◽  
Viera Alma.siova ◽  
...  
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals Specialized Vasculature in the Rostral Migratory Stream as a Neurogenic Niche and Scaffold for Neuroblast Migration

2015 ◽  
Vol 24 (3) ◽  
pp. 377-390 ◽  
Author(s):  
Ti-Fei Yuan ◽  
Yu-Xiang Liang ◽  
David Tay ◽  
Kwok-Fai So ◽  
Rutledge Ellis-Behnke
Keyword(s):  
Rostral Migratory Stream ◽  
Neurogenic Niche ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
John C. O’Donnell ◽  
Erin M. Purvis ◽  
Kaila V. T. Helm ◽  
Dayo O. Adewole ◽  
Qunzhou Zhang ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Rostral Migratory Stream ◽  
Brain Lesions ◽  
New Approach ◽  
Neuroblast Migration ◽  
Human Gingiva ◽  
Neuronal Replacement ◽  
Neuroregenerative Medicine ◽  
Migratory Stream

AbstractThe rostral migratory stream (RMS) facilitates neuroblast migration from the subventricular zone to the olfactory bulb throughout adulthood. Brain lesions attract neuroblast migration out of the RMS, but resultant regeneration is insufficient. Increasing neuroblast migration into lesions has improved recovery in rodent studies. We previously developed techniques for fabricating an astrocyte-based Tissue-Engineered RMS (TE-RMS) intended to redirect endogenous neuroblasts into distal brain lesions for sustained neuronal replacement. Here, we demonstrate that astrocyte-like-cells can be derived from adult human gingiva mesenchymal stem cells and used for TE-RMS fabrication. We report that key proteins enriched in the RMS are enriched in TE-RMSs. Furthermore, the human TE-RMS facilitates directed migration of immature neurons in vitro. Finally, human TE-RMSs implanted in athymic rat brains redirect migration of neuroblasts out of the endogenous RMS. By emulating the brain’s most efficient means for directing neuroblast migration, the TE-RMS offers a promising new approach to neuroregenerative medicine.

scholarly journals p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse

2009 ◽  
Vol 29 (9) ◽  
pp. 2902-2914 ◽  
Author(s):  
X. Li ◽  
X. Tang ◽  
B. Jablonska ◽  
A. Aguirre ◽  
V. Gallo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals Delayed maturation and altered proliferation within the rat rostral migratory stream following maternal deprivation

2011 ◽  
Vol 55 (4) ◽  
pp. 33 ◽  
Author(s):  
K. Lievajova ◽  
J. Blasko ◽  
M. Martoncikova ◽  
V. Cigankova ◽  
E. Racekova
Keyword(s):  
Maternal Deprivation ◽  
Rostral Migratory Stream ◽  
Delayed Maturation ◽  
Migratory Stream

scholarly journals The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype

2013 ◽  
Vol 109 (3) ◽  
pp. 867-872 ◽  
Author(s):  
Geeta Sharma
Keyword(s):  
Olfactory Bulb ◽  
Perceptual Learning ◽  
Progenitor Cells ◽  
Glutamate Release ◽  
Brain Regions ◽  
Odor Discrimination ◽  
Rostral Migratory Stream ◽  
Receptor Expression ◽  
Granule Cell Layer ◽  
Migratory Stream

Addition of newly generated neurons into mature neural circuits in the adult CNS responds to changes in neurotransmitter levels and is tightly coupled to the activity of specific brain regions. This postnatal neurogenesis contributes to plasticity of the olfactory bulb and hippocampus and is thought to play a role in learning and memory, context and odor discrimination, as well as perceptual learning. While acetylcholine plays an important role in odor discrimination and perceptual learning, its role in adult neurogenesis in the olfactory bulb has not been elucidated. In this study, I have examined the functional expression of nAChRs in progenitor cells of the rostral migratory stream (RMS) in the adult olfactory bulb of mice. I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Unlike in the hippocampus, the predominant functional nAChRs on progenitor cells are of α3β4 subtype. Interestingly, functional receptor expression is lost once progenitor cells mature, and are incorporated into the granule cell layer. Instead, nAChRs are now expressed on some presynaptic terminals and modulate glutamate release onto granule cells. My results imply that ACh is a part of the permissive niche and likely plays a role in development of progenitor cells.

scholarly journals Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns

2011 ◽  
Vol 5 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Noelia Martinez-Molina ◽  
Yongsoo Kim ◽  
Philip Hockberger ◽  
Francis G. Szele
Keyword(s):  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain

2011 ◽  
Vol 519 (4) ◽  
pp. 690-713 ◽  
Author(s):  
Kazunobu Sawamoto ◽  
Yuki Hirota ◽  
Clara Alfaro-Cervello ◽  
Mario Soriano-Navarro ◽  
Xiaoping He ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Common Marmoset ◽  
Rostral Migratory Stream ◽  
Cellular Composition ◽  
Migratory Stream
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