scholarly journals Delayed maturation and altered proliferation within the rat rostral migratory stream following maternal deprivation

2011 ◽  
Vol 55 (4) ◽  
pp. 33 ◽  
Author(s):  
K. Lievajova ◽  
J. Blasko ◽  
M. Martoncikova ◽  
V. Cigankova ◽  
E. Racekova
Keyword(s):  
Maternal Deprivation ◽  
Rostral Migratory Stream ◽  
Delayed Maturation ◽  
Migratory Stream

Early stress affects neurogenesis in the rat rostral migratory stream

2010 ◽  
Vol 5 (6) ◽  
pp. 757-764 ◽  
Author(s):  
Kamila Lievajová ◽  
Marcela Martončíková ◽  
Juraj Blaško ◽  
Judita Orendáčová ◽  
Viera Almašiová ◽  
...  
Keyword(s):  
Histochemical Staining ◽  
Maternal Deprivation ◽  
Postnatal Period ◽  
Rostral Migratory Stream ◽  
Neonatal Rat ◽  
Proliferating Cells ◽  
Early Stress ◽  
Stressful Experience ◽  
Dying Cells ◽  
Migratory Stream

AbstractStressful experience during the early postnatal period may influence processes associated with neurogenesis (i.e. proliferation, cell death, appearance of astrocytes or cell differentiation) in the neonatal rat rostral migratory stream (RMS). To induce stress, pups were subjected to maternal deprivation daily for three hours, starting from the first postnatal day till the seventh postnatal day. Immunohistochemical methods were used to visualize proliferating cells and astrocytes; dying cells and nitrergic cells were visualized using histochemical staining. Quantitative analysis showed that maternal deprivation decreased the number of proliferating cells and significantly increased the number of dying cells in the RMS. Maternal deprivation did not influence the appearance of astrocytes in the RMS, but caused premature differentiation of nitrergic cells. In control rats, nitrergic cells can be observed in the RMS as early as the tenth postnatal day. In maternally deprived pups, these cells were detected as early as the seventh postnatal day. The observed earlier appearance of nitrergic cells in the RMS was associated with altered proliferation and increased cell dying and this observation supports the hypothesis that nitric oxide has an anti-proliferative role in the RMS. Our study demonstrates that maternal deprivation represents a stressful condition with a profound impact on early postnatal neurogenesis.

scholarly journals p27KIP1 Regulates Neurogenesis in the Rostral Migratory Stream and Olfactory Bulb of the Postnatal Mouse

2009 ◽  
Vol 29 (9) ◽  
pp. 2902-2914 ◽  
Author(s):  
X. Li ◽  
X. Tang ◽  
B. Jablonska ◽  
A. Aguirre ◽  
V. Gallo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals The dominant functional nicotinic receptor in progenitor cells in the rostral migratory stream is the α3β4 subtype

2013 ◽  
Vol 109 (3) ◽  
pp. 867-872 ◽  
Author(s):  
Geeta Sharma
Keyword(s):  
Olfactory Bulb ◽  
Perceptual Learning ◽  
Progenitor Cells ◽  
Glutamate Release ◽  
Brain Regions ◽  
Odor Discrimination ◽  
Rostral Migratory Stream ◽  
Receptor Expression ◽  
Granule Cell Layer ◽  
Migratory Stream

Addition of newly generated neurons into mature neural circuits in the adult CNS responds to changes in neurotransmitter levels and is tightly coupled to the activity of specific brain regions. This postnatal neurogenesis contributes to plasticity of the olfactory bulb and hippocampus and is thought to play a role in learning and memory, context and odor discrimination, as well as perceptual learning. While acetylcholine plays an important role in odor discrimination and perceptual learning, its role in adult neurogenesis in the olfactory bulb has not been elucidated. In this study, I have examined the functional expression of nAChRs in progenitor cells of the rostral migratory stream (RMS) in the adult olfactory bulb of mice. I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Unlike in the hippocampus, the predominant functional nAChRs on progenitor cells are of α3β4 subtype. Interestingly, functional receptor expression is lost once progenitor cells mature, and are incorporated into the granule cell layer. Instead, nAChRs are now expressed on some presynaptic terminals and modulate glutamate release onto granule cells. My results imply that ACh is a part of the permissive niche and likely plays a role in development of progenitor cells.

scholarly journals Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns

2011 ◽  
Vol 5 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Noelia Martinez-Molina ◽  
Yongsoo Kim ◽  
Philip Hockberger ◽  
Francis G. Szele
Keyword(s):  
Rostral Migratory Stream ◽  
Migratory Stream

scholarly journals Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain

2011 ◽  
Vol 519 (4) ◽  
pp. 690-713 ◽  
Author(s):  
Kazunobu Sawamoto ◽  
Yuki Hirota ◽  
Clara Alfaro-Cervello ◽  
Mario Soriano-Navarro ◽  
Xiaoping He ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Common Marmoset ◽  
Rostral Migratory Stream ◽  
Cellular Composition ◽  
Migratory Stream

scholarly journals Effect of methotrexate on rostral migratory stream in newborn rats

2015 ◽  
Vol 77 (12) ◽  
pp. 1565-1571 ◽  
Author(s):  
Ayano HIRAKO ◽  
Jin SUN ◽  
Satoshi FURUKAWA ◽  
Takashi TAKEUCHI ◽  
Akihiko SUGIYAMA
Keyword(s):  
Rostral Migratory Stream ◽  
Newborn Rats ◽  
Migratory Stream

scholarly journals  1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream

2007 ◽  
Vol 27 (10) ◽  
pp. 2704-2717 ◽  
Author(s):  
R. Belvindrah ◽  
S. Hankel ◽  
J. Walker ◽  
B. L. Patton ◽  
U. Muller
Keyword(s):  
Rostral Migratory Stream ◽  
Migratory Stream
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