scholarly journals KCa3.1 Modulates Neuroblast Migration Along the Rostral Migratory Stream (RMS) In Vivo

2013 ◽  
Vol 24 (9) ◽  
pp. 2388-2400 ◽  
Author(s):  
Kathryn L. Turner ◽  
Harald Sontheimer
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration

2017 ◽  
Vol 114 (10) ◽  
pp. E2006-E2015 ◽  
Author(s):  
János Hanics ◽  
Edit Szodorai ◽  
Giuseppe Tortoriello ◽  
Katarzyna Malenczyk ◽  
Erik Keimpema ◽  
...  
Keyword(s):  
Annexin V ◽  
Therapeutic Benefit ◽  
Mouse Genetics ◽  
Matrix Metalloprotease ◽  
Loss Of Function ◽  
Neuroblast Migration ◽  
Sensor Protein ◽  
Migratory Stream

The rostral migratory stream (RMS) is viewed as a glia-enriched conduit of forward-migrating neuroblasts in which chemorepulsive signals control the pace of forward migration. Here we demonstrate the existence of a scaffold of neurons that receive synaptic inputs within the rat, mouse, and human fetal RMS equivalents. These neurons express secretagogin, a Ca2+-sensor protein, to execute an annexin V-dependent externalization of matrix metalloprotease-2 (MMP-2) for reconfiguring the extracellular matrix locally. Mouse genetics combined with pharmacological probing in vivo and in vitro demonstrate that MMP-2 externalization occurs on demand and that its loss slows neuroblast migration. Loss of function is particularly remarkable upon injury to the olfactory bulb. Cumulatively, we identify a signaling cascade that provokes structural remodeling of the RMS through recruitment of MMP-2 by a previously unrecognized neuronal constituent. Given the life-long presence of secretagogin-containing neurons in human, this mechanism might be exploited for therapeutic benefit in rescue strategies.

scholarly journals Age-dependent visualization of neural progenitor cells within the rostral migratory stream via MRI and endogenously labeled micron-sized iron oxide particles

2018 ◽  
Author(s):  
Dorela D. Shuboni-Mulligan ◽  
Shatadru Chakravarty ◽  
Christiane L. Mallett ◽  
Alexander M. Wolf ◽  
Stacey Forton ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Ex Vivo ◽  
Neural Progenitor ◽  
Rostral Migratory Stream ◽  
Iron Oxide Particles ◽  
The Impact ◽  
Migratory Stream

AbstractThe subventricular zone (SVZ) is one of the primary sources for rodent neural progenitor cells (NPC), however, aging greatly impacts the substructure of the region and rate of new cell birth. To determine if age impacts the rate of in vivo migration within animals, we examined the rostral migratory stream (RMS) of animals across 12 days using an established MRI technique. To visualize NPCs, we injected micron sized particles of iron oxide (MPIO) into the lateral ventricle to endogenously label cells within the SVZ, which then appeared as hypo-intensive spots within MR images. Our in vivo MRI data showed that the rate of migration was significantly different between all ages examined, with decreases in the distance traveled as age progressed. The total number of iron oxide labeled cells within the olfactory bulb on day 12, decrease significantly when compared across ages in ex vivo high-resolution scans. We also, for the first time, demonstrated the endogenous labeling of cells within the dentate gyrus (DG) of hippocampus. Here too, there was a significant decrease in the number of labeled cells within the structure across age. Histology of the NPCs verified the decrease in labeling of cells with doublecortin (DCX) as age progressed for both regions. The dramatic reduction of labeling in NPCs within the SVZ and DG observed with MRI, demonstrates the importance of understanding the impact of age on the relationship of NPC and disease.

The rostral migratory stream is a neurogenic niche that predominantly engenders periglomerular cells: In vivo evidence in the adult rat brain

2008 ◽  
Vol 60 (3) ◽  
pp. 289-299 ◽  
Author(s):  
Julieta G. Mendoza-Torreblanca ◽  
Eduardo Martínez-Martínez ◽  
Miguel Tapia-Rodríguez ◽  
Rogelio Ramírez-Hernández ◽  
Gabriel Gutiérrez-Ospina
Keyword(s):  
Rat Brain ◽  
Rostral Migratory Stream ◽  
Neurogenic Niche ◽  
Adult Rat ◽  
Adult Rat Brain ◽  
Migratory Stream ◽  
Periglomerular Cells

scholarly journals A new function for Prokineticin 2: recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury

2018 ◽  
Author(s):  
Mayara Vieira Mundim ◽  
Laura Nicoleti Zamproni ◽  
Agnes Araújo Sardinha Pinto ◽  
Layla Testa Galindo ◽  
André Machado Xavier ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Subventricular Zone ◽  
Brain Injuries ◽  
Rostral Migratory Stream ◽  
Subgranular Zone ◽  
Prokineticin 2 ◽  
Migratory Stream

AbstractTraumatic brain injury is an important cause of mortality and morbidity all over the world. After the initial injury there is a cascade of cellular and molecular events that ultimately lead to cell death. Therapies aim not only to counteract these mechanisms but also to replenish the lost cell population in order to achieve a better recovery. The adult mammal brain in not as plastic as the postnatal, but it has at least two neurogenic regions that maintains physiological functions in the brain; the subgranular zone of the dentate gyrus of the hippocampus, which produces neurons that integrate locally, and the subventricular zone (SVZ) of the lateral ventricles, that produces neuroblasts that migrate through the rostral migratory stream (RMS) to the olfactory bulbs. Brain injuries, as well as neurodegenerative diseases, induce the SVZ to respond by increasing cell proliferation and migration to the injured areas. Here we report that SVZ cells migrate to the injured cortex after traumatic brain injury in mice, and that the physiological RMS migration is not impaired. We also show that Prokineticin 2 (PROK2), a chemokine important for the olfactory bulb neurogenesis by promoting the directional migration of neuroblasts, is induced in the injured cortex. Using PROK2 receptor antagonist and recombinant PROK2 we show for the first time that PROK2 can directionally attract SVZ cells in vitro and in vivo. The data we present here links one more element of the inflammatory process, PROK2 secreted by microglia, to the attempt to regenerate an acutely injured mammalian cortex.AbbreviationsSGZsubgranular zoneSVZsubventricular zoneRMSrostral migratory streamPROK2Prokineticin 2

Astrocytic and Vascular Scaffolding for Neuroblast Migration in the Rostral Migratory Stream

2014 ◽  
Vol 11 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Marcela Marton.cikova ◽  
Kamila Fabianova ◽  
Andrea Schreiberova ◽  
Juraj Bla.sko ◽  
Viera Alma.siova ◽  
...  
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals VEGFR-1 Regulates Adult Olfactory Bulb Neurogenesis and Migration of Neural Progenitors in the Rostral Migratory Stream In Vivo

2009 ◽  
Vol 29 (27) ◽  
pp. 8704-8714 ◽  
Author(s):  
I. M. Wittko ◽  
A. Schanzer ◽  
A. Kuzmichev ◽  
F. T. Schneider ◽  
M. Shibuya ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Rostral Migratory Stream ◽  
Neural Progenitors ◽  
And Migration ◽  
Migratory Stream

β8 integrin is essential for neuroblast migration in the rostral migratory stream

Glia ◽  
2011 ◽  
Vol 59 (11) ◽  
pp. 1579-1587 ◽  
Author(s):  
Aaron K. Mobley ◽  
Joseph H. McCarty
Keyword(s):  
Rostral Migratory Stream ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals Specialized Vasculature in the Rostral Migratory Stream as a Neurogenic Niche and Scaffold for Neuroblast Migration

2015 ◽  
Vol 24 (3) ◽  
pp. 377-390 ◽  
Author(s):  
Ti-Fei Yuan ◽  
Yu-Xiang Liang ◽  
David Tay ◽  
Kwok-Fai So ◽  
Rutledge Ellis-Behnke
Keyword(s):  
Rostral Migratory Stream ◽  
Neurogenic Niche ◽  
Neuroblast Migration ◽  
Migratory Stream

scholarly journals An implantable human stem cell-derived tissue-engineered rostral migratory stream for directed neuronal replacement

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
John C. O’Donnell ◽  
Erin M. Purvis ◽  
Kaila V. T. Helm ◽  
Dayo O. Adewole ◽  
Qunzhou Zhang ◽  
...  
Keyword(s):  
Subventricular Zone ◽  
Rostral Migratory Stream ◽  
Brain Lesions ◽  
New Approach ◽  
Neuroblast Migration ◽  
Human Gingiva ◽  
Neuronal Replacement ◽  
Neuroregenerative Medicine ◽  
Migratory Stream

AbstractThe rostral migratory stream (RMS) facilitates neuroblast migration from the subventricular zone to the olfactory bulb throughout adulthood. Brain lesions attract neuroblast migration out of the RMS, but resultant regeneration is insufficient. Increasing neuroblast migration into lesions has improved recovery in rodent studies. We previously developed techniques for fabricating an astrocyte-based Tissue-Engineered RMS (TE-RMS) intended to redirect endogenous neuroblasts into distal brain lesions for sustained neuronal replacement. Here, we demonstrate that astrocyte-like-cells can be derived from adult human gingiva mesenchymal stem cells and used for TE-RMS fabrication. We report that key proteins enriched in the RMS are enriched in TE-RMSs. Furthermore, the human TE-RMS facilitates directed migration of immature neurons in vitro. Finally, human TE-RMSs implanted in athymic rat brains redirect migration of neuroblasts out of the endogenous RMS. By emulating the brain’s most efficient means for directing neuroblast migration, the TE-RMS offers a promising new approach to neuroregenerative medicine.

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