High-affinity GABA uptake in retinal glial (Müller) cells of the guinea pig: Electrophysiological characterization, immunohistochemical localization, and modeling of efficiency

Glia ◽  
2002 ◽  
Vol 39 (3) ◽  
pp. 217-228 ◽  
Author(s):  
Bernd Biedermann ◽  
Andreas Bringmann ◽  
Andreas Reichenbach
Keyword(s):  
Guinea Pig ◽  
Müller Cells ◽  
Immunohistochemical Localization ◽  
Gaba Uptake ◽  
Muller Cells ◽  
High Affinity ◽  
Electrophysiological Characterization

Outwardly rectifying K+ channels display clustering in guinea pig retinal Müller cells

1999 ◽  
Vol 276 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Thomas Pannicke ◽  
Andreas Reichenbach ◽  
Winfried Reichelt
Keyword(s):  
Guinea Pig ◽  
Müller Cells ◽  
Muller Cells ◽  
K Channels

Rabbit retinal neurons and glia express a variety of ENaC/DEG subunits

2002 ◽  
Vol 283 (1) ◽  
pp. C126-C134 ◽  
Author(s):  
L. M. Brockway ◽  
Z.-H. Zhou ◽  
J. K. Bubien ◽  
B. Jovov ◽  
D. J. Benos ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Müller Cells ◽  
Immunohistochemical Localization ◽  
Mammalian Brain ◽  
Rabbit Retina ◽  
Muller Cells ◽  
Retinal Neurons ◽  
Cellular Expression ◽  
The Central Nervous System ◽  
First Time

Some members of the epithelial Na+ channel/degenerin (ENaC/DEG) family of ion channels have been detected in mammalian brain. Therefore, we examined the RNA and protein expression of these channels in another part of the central nervous system, the rabbit retina. We next sought to demonstrate physiological evidence for an amiloride-sensitive current in Müller glia, which, on the basis of a previous study, are thought to express α-ENaC (Golestaneh N, de Kozak Y, Klein C, and Mirshahi M. Glia 33: 160–168, 2001). RT-PCR of retinal RNA revealed the presence of α-, β-, γ-, and δ-ENaC as well as acid-sensing ion channel (ASIC)1, ASIC2, ASIC3, and ASIC4. Immunohistochemical localization with antibodies against α-ENaC and β-ENaC showed labeling in Müller cells and neurons, respectively. The presence of α-ENaC, β-ENaC, and ASIC1 was detected by Western blotting. Cultured Müller cells were whole cell patch clamped. These cells exhibited an inward Na+ current that was blocked by amiloride. These data demonstrate for the first time both the expression of a variety of ENaC and ASIC subunits in the rabbit retina as well as distinct cellular expression patterns of specific subunits in neurons and glia.

Gene Expression of Neurotrophins and Their High-Affinity Trk Receptors in Cultured Human Müller Cells

2002 ◽  
Vol 34 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Hidehiro Oku ◽  
Tsunehiko Ikeda ◽  
Youichi Honma ◽  
Chie Sotozono ◽  
Kohji Nishida ◽  
...  
Keyword(s):  
Gene Expression ◽  
Müller Cells ◽  
Muller Cells ◽  
Trk Receptors ◽  
High Affinity

Patch-clamp recordings from Müller (glial) cell endfeet in the intact isolated retina and acutely isolated Müller cells of mouse and guinea-pig

Neuroscience ◽  
1993 ◽  
Vol 57 (3) ◽  
pp. 599-613 ◽  
Author(s):  
W. Reichelt ◽  
T. Müller ◽  
A. Pastor ◽  
T. Pannicke ◽  
P.M. Orkand ◽  
...  
Keyword(s):  
Patch Clamp ◽  
Guinea Pig ◽  
Glial Cell ◽  
Müller Cells ◽  
Muller Cells ◽  
Müller Glial Cell ◽  
Isolated Retina

Immunohistochemical localization of mitochondrial fatty acid β-oxidation enzymes in Müller cells of the retina

2010 ◽  
Vol 134 (6) ◽  
pp. 565-579 ◽  
Author(s):  
Kimie Atsuzawa ◽  
Ayami Nakazawa ◽  
Kenmei Mizutani ◽  
Motoaki Fukasawa ◽  
Naoki Yamamoto ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Müller Cells ◽  
Immunohistochemical Localization ◽  
Muller Cells ◽  
Mitochondrial Fatty Acid

K+ Channels of Müller Glial Cells in Retinal Disorders

2018 ◽  
Vol 17 (4) ◽  
pp. 255-260 ◽  
Author(s):  
Feng Gao ◽  
Lin-Jie Xu ◽  
Yuan Zhao ◽  
Xing-Huai Sun ◽  
Zhongfeng Wang
Keyword(s):  
Müller Cells ◽  
Major Type ◽  
Delayed Rectifier ◽  
Muller Cells ◽  
Bkca Channels ◽  
K Channels ◽  
Functional Changes ◽  
Physiological Properties ◽  
Retinal Disorders ◽  
Inwardly Rectifying

Background & Objective: Müller cell is the major type of glial cell in the vertebrate retina. Müller cells express various types of K+ channels, such as inwardly rectifying K+ (Kir) channels, big conductance Ca2+-activated K+ (BKCa) channels, delayed rectifier K+ channels (KDR), and transient A-type K+ channels. These K+ channels play important roles in maintaining physiological functions of Müller cells. Under some retinal pathological conditions, the changed expression and functions of K+ channels may contribute to retinal pathogenesis. Conclusion: In this article, we reviewed the physiological properties of K+ channels in retinal Müller cells and the functional changes of these channels in retinal disorders.

scholarly journals Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway

2021 ◽  
Vol 137 ◽  
pp. 111274
Author(s):  
Yuanyuan Tu ◽  
E Song ◽  
Zhenzhen Wang ◽  
Na Ji ◽  
Linling Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Müller Cells ◽  
Muller Cells
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