scholarly journals Flexible and Robust Methods for Rare-Variant Testing of Quantitative Traits in Trios and Nuclear Families

2014 ◽  
Vol 38 (6) ◽  
pp. 542-551 ◽  
Author(s):  
Yunxuan Jiang ◽  
Karen N. Conneely ◽  
Michael P. Epstein
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Robust Methods ◽  
Nuclear Families

scholarly journals Comparison of statistical approaches to rare variant analysis for quantitative traits

2011 ◽  
Vol 5 (S9) ◽  
Author(s):  
Han Chen ◽  
Audrey E Hendricks ◽  
Yansong Cheng ◽  
Adrienne L Cupples ◽  
Josée Dupuis ◽  
...  
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Rare Variant Analysis ◽  
Statistical Approaches ◽  
Variant Analysis

scholarly journals Leveraging population information in family-based rare variant association analyses of quantitative traits

2016 ◽  
Vol 41 (2) ◽  
pp. 98-107 ◽  
Author(s):  
Yu Jiang ◽  
Yunqi Ji ◽  
Alexander B. Sibley ◽  
Yi-Ju Li ◽  
Andrew S. Allen
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Rare Variant Association ◽  
Association Analyses ◽  
Population Information ◽  
Family Based

scholarly journals Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children

2011 ◽  
Vol 174 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Feng He ◽  
Ji-Yuan Zhou ◽  
Yue-Qing Hu ◽  
Fengzhu Sun ◽  
Jingyuan Yang ◽  
...  
Keyword(s):  
Quantitative Traits ◽  
Nuclear Families ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

2000 ◽  
Vol 8 (11) ◽  
pp. 853-860 ◽  
Author(s):  
Lyle J Palmer ◽  
Paul R Burton ◽  
Alan L James ◽  
A William Musk ◽  
William OCM Cookson
Keyword(s):  
Quantitative Traits ◽  
Familial Aggregation ◽  
Population Based ◽  
Nuclear Families

scholarly journals Detecting Rare Variants for Quantitative Traits Using Nuclear Families

2012 ◽  
Vol 73 (3) ◽  
pp. 148-158 ◽  
Author(s):  
Wei Guo ◽  
Yin Yao Shugart
Keyword(s):  
Quantitative Traits ◽  
Rare Variants ◽  
Nuclear Families

scholarly journals Adjusting for Common Variant Polygenic Scores Improves Yield in Rare Variant Association Analyses

2021 ◽  
Author(s):  
Sean J. Jurgens ◽  
James P. Pirruccello ◽  
Seung Hoan Choi ◽  
Valerie N. Morrill ◽  
Mark D. Chaffin ◽  
...  
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Large Scale ◽  
Common Variant ◽  
Sequencing Data ◽  
Rare Variant Association ◽  
Association Analyses ◽  
Polygenic Scores ◽  
Association Discovery ◽  
The Uk

With the emergence of large-scale sequencing data, methods for improving power in rare variant analyses (RVAT) are needed. Here, we show that adjusting for common variant polygenic scores improves the yield in gene-based RVAT across 65 quantitative traits in the UK Biobank (up to 20% increase at α=2.6x10-6), without a marked increase in false-positive rates or genomic inflation. Our results illustrate how adjusting for common variant effects can aid in rare variant association discovery.

A rare variant association test in family-based designs and non-normal quantitative traits

2015 ◽  
Vol 35 (6) ◽  
pp. 905-921 ◽  
Author(s):  
Lajmi Lakhal-Chaieb ◽  
Karim Oualkacha ◽  
Brent J. Richards ◽  
Celia M.T. Greenwood
Keyword(s):  
Rare Variant ◽  
Quantitative Traits ◽  
Association Test ◽  
Rare Variant Association ◽  
Family Based ◽  
Rare Variant Association Test
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