scholarly journals Detecting Rare Variants for Quantitative Traits Using Nuclear Families

2012 ◽  
Vol 73 (3) ◽  
pp. 148-158 ◽  
Author(s):  
Wei Guo ◽  
Yin Yao Shugart
Keyword(s):  
Quantitative Traits ◽  
Rare Variants ◽  
Nuclear Families

scholarly journals Detection of Parent-of-Origin Effects for Quantitative Traits in Complete and Incomplete Nuclear Families With Multiple Children

2011 ◽  
Vol 174 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Feng He ◽  
Ji-Yuan Zhou ◽  
Yue-Qing Hu ◽  
Fengzhu Sun ◽  
Jingyuan Yang ◽  
...  
Keyword(s):  
Quantitative Traits ◽  
Nuclear Families ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

2000 ◽  
Vol 8 (11) ◽  
pp. 853-860 ◽  
Author(s):  
Lyle J Palmer ◽  
Paul R Burton ◽  
Alan L James ◽  
A William Musk ◽  
William OCM Cookson
Keyword(s):  
Quantitative Traits ◽  
Familial Aggregation ◽  
Population Based ◽  
Nuclear Families

scholarly journals A Flexible Approach for the Analysis of Rare Variants Allowing for a Mixture of Effects on Binary or Quantitative Traits

PLoS Genetics ◽  
2013 ◽  
Vol 9 (8) ◽  
pp. e1003694 ◽  
Author(s):  
Geraldine M. Clarke ◽  
Manuel A. Rivas ◽  
Andrew P. Morris
Keyword(s):  
Quantitative Traits ◽  
Rare Variants ◽  
Flexible Approach

scholarly journals Exome sequencing identifies high-impact trait-associated alleles enriched in Finns

2018 ◽  
Author(s):  
Adam E Locke ◽  
Karyn Meltz Steinberg ◽  
Charleston WK Chiang ◽  
Susan K Service ◽  
Aki S Havulinna ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Quantitative Traits ◽  
Rare Variants ◽  
Mendelian Disease ◽  
Finnish Population ◽  
Isolated Populations ◽  
Deleterious Alleles ◽  
Disease Mutations ◽  
Sequencing Studies ◽  
Novel Associations

ABSTRACTAs yet undiscovered rare variants are hypothesized to substantially influence an individual’s risk for common diseases and traits, but sequencing studies aiming to identify such variants have generally been underpowered. In isolated populations that have expanded rapidly after a population bottleneck, deleterious alleles that passed through the bottleneck may be maintained at much higher frequencies than in other populations. In an exome sequencing study of nearly 20,000 cohort participants from northern and eastern Finnish populations that exemplify this phenomenon, most novel trait-associated deleterious variants are seen only in Finland or display frequencies more than 20 times higher than in other European populations. These enriched alleles underlie 34 novel associations with 21 disease-related quantitative traits and demonstrate a geographical clustering equivalent to that of Mendelian disease mutations characteristic of the Finnish population. Sequencing studies in populations without this unique history would require hundreds of thousands to millions of participants for comparable power for these variants.

scholarly journals A General Test of Association for Quantitative Traits in Nuclear Families

2000 ◽  
Vol 66 (1) ◽  
pp. 279-292 ◽  
Author(s):  
G.R. Abecasis ◽  
L.R. Cardon ◽  
W.O.C. Cookson
Keyword(s):  
Quantitative Traits ◽  
Nuclear Families ◽  
General Test
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