Relationship uncertainty linkage statistics (RULS): affected relative pair statistics that model relationship uncertainty

2008 ◽  
Vol 32 (4) ◽  
pp. 313-324 ◽  
Author(s):  
Amrita Ray ◽  
Daniel E. Weeks
Keyword(s):  
Relative Pair ◽  
Affected Relative ◽  
Affected Relative Pair

Prediction of Empirical p Values from Asymptotic p Values for Conditional Logistic Affected Relative Pair Linkage Analysis

2006 ◽  
Vol 61 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Moumita Sinha ◽  
Yeunjoo Song ◽  
Robert C. Elston ◽  
Jane M. Olson ◽  
Katrina A.B. Goddard
Keyword(s):  
Linkage Analysis ◽  
Relative Pair ◽  
P Values ◽  
Affected Relative ◽  
Affected Relative Pair

Development of a questionnaire to identify persons with a family history of aneurysmal subarachnoid hemorrhage

2022 ◽  
pp. 174749302110690
Author(s):  
Charlotte CM Zuurbier ◽  
Jacoba P Greving ◽  
Gabriel JE Rinkel ◽  
Ynte M Ruigrok
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Family History ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Positive Family History ◽  
Stroke Patients ◽  
Degree Relative ◽  
First Degree Relatives ◽  
Family History Questionnaire ◽  
Affected Relative ◽  
History Of

Background: Preventive screening for intracranial aneurysms is effective in persons with a positive family history of aneurysmal subarachnoid hemorrhage (aSAH), but for many relatives of aSAH patients, it can be difficult to assess whether their relative had an aSAH or another type of stroke. Aim: We aimed to develop a family history questionnaire for people in the population who believe they have a first-degree relative who had a stroke and to assess its accuracy to identify relatives of aSAH patients. Methods: A questionnaire to distinguish between aSAH and other stroke types (ischemic stroke and intracerebral hemorrhage) was developed by a team of clinicians and consumers. The level of agreement between the questionnaire outcome and medical diagnosis was pilot tested in 30 previously admitted aSAH patients. Next, the sensitivity and specificity of the questionnaire were assessed in 91 first-degree relatives (siblings/children) of previously admitted stroke patients. Results: All 30 aSAH patients were identified by the questionnaire in the pilot study; 29 of 30 first-degree relatives of aSAH patients were correctly identified. The questionnaire had a sensitivity of 97% (95% confidence interval (CI) = 83–100%) and a specificity of 93% (95% CI = 84–98%) when tested in the first-degree relatives of stroke patients. Conclusion: Our questionnaire can help persons to discriminate an aSAH from other types of stroke in their affected relative. This family history questionnaire is developed in the Netherlands but could also be used in other countries after validation.

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