scholarly journals Experimental research Effects of captopril on factors affecting gastric mucosal integrity in aspirin-induced gastric lesions in Sprague-Dawley rats

2013 ◽  
Vol 6 ◽  
pp. 1132-1137 ◽  
Author(s):  
Nafeeza Mohd Ismail ◽  
Ibrahim Abdel Aziz Ibrahim ◽  
Najihah MB ◽  
Kamsiah Jaarin
Keyword(s):  
Experimental Research ◽  
Gastric Lesions ◽  
Sprague Dawley ◽  
Factors Affecting ◽  
Mucosal Integrity ◽  
Sprague Dawley Rats

scholarly journals The effect of cocaine on gastric mucosal PGE2, LTC4and ulcerations

1993 ◽  
Vol 2 (5) ◽  
pp. 363-365
Author(s):  
L. D. G. Angus ◽  
T. A. Stein ◽  
L. J. Auguste ◽  
J. Gintautas ◽  
J. Westervelt ◽  
...  
Keyword(s):  
Fold Increase ◽  
Prostaglandin E ◽  
Sprague Dawley ◽  
Cocaine Use ◽  
Mucosal Ulceration ◽  
Mucosal Integrity ◽  
Sprague Dawley Rats ◽  
Gastroduodenal Perforation ◽  
Cold Restraint

The association between cocaine use and acute gastroduodenal perforation is known. The effect of cocaine and stress on gastric mucosal ulceration and the levels of prostaglandin E2(PGE2) and leukotriene C4(LTC4) was studied in 40 Sprague–Dawley rats. Controls received intraperitoneal (i.p.) saline, ten received i.p. cocaine (35 mg/kg), ten were stressed by the cold restraint method, and ten had i.p. cocaine and stress. Cocaine alone did not induce ulceration, but decreased PGE2levels. Stress alone caused ulceration, but was not associated with a change in either PGE2or LTC4levels. When combined with stress, however, cocaine caused a three-fold increase in ulceration and a significant increase in PGE2and LTC4levels. Stress may predispose the cocaine addict to loss of gastroduodenal mucosal integrity, which is related to an imbalance of PGE2and LTC4synthesis.

Social Factors Affecting Emotionality and Resistance to Disease in Animals: IV. Differential Housing, Emotionality, and Walker 256 Carcinosarcoma in the Rat

1964 ◽  
Vol 15 (2) ◽  
pp. 535-541 ◽  
Author(s):  
Robert Ader ◽  
Stanford B. Friedman
Keyword(s):  
Social Factors ◽  
Emotional Reactivity ◽  
Sprague Dawley ◽  
Systematic Observation ◽  
Factors Affecting ◽  
Transplanted Tumor ◽  
Sprague Dawley Rats ◽  
Differential Housing ◽  
Walker 256 ◽  
Standard Tests

Two experiments were conducted in which male, Sprague-Dawley rats were housed individually or in groups of 5 to 7 per cage from weaning until maturity. On the standard tests of emotionality there were large and consistent differences in emotional reactivity between the differentially reared groups. Also, systematic observation of reactions to handling showed significantly more startle, vocalization, and resistance to being picked up in the individually-housed animals. There were no differences between the group- and individually-reared animals in their responses to the transplanted tumor.

Factors affecting mortality in tumorigenlclty studies conducted on gang-housed sprague-dawley rats

1994 ◽  
Vol 74 ◽  
pp. 37
Author(s):  
W.N. Hooks ◽  
C. Gopinath ◽  
D.F. Newton ◽  
R.J. Harling
Keyword(s):  
Sprague Dawley ◽  
Factors Affecting ◽  
Sprague Dawley Rats

scholarly journals Ethanolic extract of okra has a potential gastroprotective effect on acute gastric lesions in Sprague Dawley rats

2020 ◽  
Vol 8 (12) ◽  
pp. 6691-6698 ◽  
Author(s):  
Hafsa Yasin ◽  
Farwa Tariq ◽  
Aysha Sameen ◽  
Nazir Ahmad ◽  
Muhammad Faisal Manzoor ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Gastric Lesions ◽  
Sprague Dawley ◽  
Gastroprotective Effect ◽  
Sprague Dawley Rats

Rat lingual lipase: factors affecting enzyme activity and secretion.

1978 ◽  
Vol 235 (4) ◽  
pp. E416 ◽  
Author(s):  
M Hamosh
Keyword(s):  
Enzyme Activity ◽  
Subcellular Localization ◽  
Corn Oil ◽  
Secretory Granules ◽  
Fat Content ◽  
Control Group ◽  
Sprague Dawley ◽  
High Fat ◽  
Factors Affecting ◽  
Sprague Dawley Rats

The lingual serous glands of rat tongue secrete a potent lipase that acts in the stomach in which it initiates the digestion of dietary fat. The subcellular localization of the enzyme and factors affecting its activity and secretion were studied in adult male Sprague-Dawley rats. In a fraction rich in secretory granules, 42% of the lipase content of lingual serous glands was recovered after fractionation of homogenates of discontinuous gradients of urografin in 0.3 M sucrose. Lipase secretion was stimulated by isoprenaline: 2 h after isoprenaline administration, the lipase content of lingual serous glands was 73 +/- 5% lower than that of the control group. Accumulation of lipase began 8 h after the injection, reaching 57 +/- 7% of the initial level of the control group after 25 h. Bilateral resection of the glosso-pharyngeal nerves or bilateral sympathectomy led to a 40--50% decrease of enzyme activity in 7 days. Enzyme activity was markedly affected by the fat content of the diet. Feeding a high-fat diet (22% corn oil) for a period of 2 wk led to a 45% increase in the lipase content of lingual serous glands. The exponential rise in the lipase activity of the lingual serous glands immediately after birth could be related to the high-fat content of rat milk. The data suggest that the lingual serous glands are similar to other exocrine glands such as pancreas and parotid gland in the subcellular localization of secretory enzymes and mechanisms of enzyme secretion.

A Confocal scanning laser microscopic study of the developing heart

1991 ◽  
Vol 49 ◽  
pp. 398-399
Author(s):  
C. Chintanawonges
Keyword(s):  
Heart Development ◽  
Scanning Laser ◽  
Confocal Scanning Laser Microscopy ◽  
Sprague Dawley ◽  
Factors Affecting ◽  
Developing Heart ◽  
Sprague Dawley Rats ◽  
Confocal Scanning ◽  
Confocal Scanning Laser ◽  
Developing Rat

During heart development myofibrillogenesis and myocyte fiber pattern formation are critical steps in the genesis of a functional four chambered pump. The factors affecting these morphogenetic patterns are complex and include mechanical and chemical regulatory agents. The long range goal of this research is to model the effects of mechanical stimulation on heart development. In order to accomplish this goal, accurate images of the fiber patterns in the myocardium are necessary at various stages of development. In this study, we have used confocal scanning laser microscopy and immunofluorescence staining to visualize the fiber patterns and myofibrils in the developing rat heart. Sprague-Dawley rats at 10-15.5 days of gestation (Plug date was designated as day 0 with noon of plug date being designated as day 0.5) were sacrificed by lethal injection of anesthetic and their embryos were fixed in 2.0% paraformaldehyde in 0.1 M HEPES (PH 7.2) for 4-8 hours at 4°C.

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

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