Genotoxicity testing of the herbicide trifluralin and its commercial formulation Treflan using the piscine micronucleus test

2008 ◽  
Vol 49 (6) ◽  
pp. 434-438 ◽  
Author(s):  
Serpil Könen ◽  
Tolga Çavaş
Keyword(s):  
Micronucleus Test ◽  
Commercial Formulation ◽  
Genotoxicity Testing ◽  
Piscine Micronucleus Test

Evaluation of river water genotoxicity using the piscine micronucleus test

2007 ◽  
Vol 48 (6) ◽  
pp. 421-429 ◽  
Author(s):  
Serap Ergene ◽  
Tolga Çavaş ◽  
Ayla Çelik ◽  
Nurcan Köleli ◽  
Cemil Aymak
Keyword(s):  
River Water ◽  
Micronucleus Test ◽  
Piscine Micronucleus Test

Genotoxicity testing of Cecropia obtusifolia extracts in two in vivo assays: The wing somatic mutation and recombination test of Drosophila and the human cytokinesis-block micronucleus test

2008 ◽  
Vol 116 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Varenka Martínez Toledo ◽  
María Guadalupe Ordáz Tellez ◽  
América Nitxin Castañeda Sortibrán ◽  
Adolfo Andrade-Cetto ◽  
Rosario Rodríguez-Arnaiz
Keyword(s):  
Somatic Mutation ◽  
Micronucleus Test ◽  
In Vivo Assays ◽  
Cecropia Obtusifolia ◽  
Genotoxicity Testing

scholarly journals Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO2 Nanoparticles on SH-SY5Y Cells

2021 ◽  
Vol 22 (16) ◽  
pp. 8558
Author(s):  
Natalia Fernández-Bertólez ◽  
Fátima Brandão ◽  
Carla Costa ◽  
Eduardo Pásaro ◽  
João Paulo Teixeira ◽  
...  
Keyword(s):  
Cytochalasin B ◽  
Positive Response ◽  
Micronucleus Test ◽  
Treatment Options ◽  
Toxicity Tests ◽  
Cyt B ◽  
Cbmn Assay ◽  
Dose Dependent ◽  
Genotoxicity Testing

Standard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) test is recommended for genotoxicity testing, but cytochalasin-B (Cyt-B) may interfere with nanoparticles (NP), leading to inaccurate results. Our objective was to determine whether Cyt-B could interfere with MN induction by TiO2 NP in human SH-SY5Y cells, as assessed by CBMN test. Cells were treated for 6 or 24 h, according to three treatment options: co-treatment with Cyt-B, post-treatment, and delayed co-treatment. Influence of Cyt-B on TiO2 NP cellular uptake and MN induction as evaluated by flow cytometry (FCMN) were also assessed. TiO2 NP were significantly internalized by cells, both in the absence and presence of Cyt-B, indicating that this chemical does not interfere with NP uptake. Dose-dependent increases in MN rates were observed in CBMN test after co-treatment. However, FCMN assay only showed a positive response when Cyt-B was added simultaneously with TiO2 NP, suggesting that Cyt-B might alter CBMN assay results. No differences were observed in the comparisons between the treatment options assessed, suggesting they are not adequate alternatives to avoid Cyt-B interference in the specific conditions tested.

The piscine micronucleus test to assess the impact of pollution on the Japaratuba river in Brazil

2006 ◽  
Vol 47 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Silmara de Moraes Pantaleão ◽  
Ayda Vera Alcântara ◽  
José do Patrocínio Hora Alves ◽  
Mário Antônio Spanó
Keyword(s):  
Micronucleus Test ◽  
The Impact ◽  
Piscine Micronucleus Test

Evaluation of genotoxicity from Nilufer Stream (Bursa/Turkey) water using piscine micronucleus test

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2443-2447 ◽  
Author(s):  
Senay Summak ◽  
Nilufer Cinkilic Aydemir ◽  
Ozgür Vatan ◽  
Dilek Yılmaz ◽  
Tolga Zorlu ◽  
...  
Keyword(s):  
Micronucleus Test ◽  
Piscine Micronucleus Test

Genotoxicity testing of sulfur dioxide (SO2) in a mouse bone marrow micronucleus test complemented with hematological endpoints

2010 ◽  
Vol 697 (1-2) ◽  
pp. 38-46 ◽  
Author(s):  
Christina Ziemann ◽  
Tanja Hansen ◽  
Gerhard Pohlmann ◽  
David Farrar ◽  
Christina Pohlenz-Michel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Sulfur Dioxide ◽  
Micronucleus Test ◽  
Mouse Bone Marrow ◽  
Genotoxicity Testing ◽  
Bone Marrow Micronucleus

scholarly journals Toxicity and Genotoxicity Testing of Roundup

2009 ◽  
Vol 63 (1-2) ◽  
pp. 29-32
Author(s):  
Jēkabs Raipulis ◽  
Malda Toma ◽  
Maija Balode
Keyword(s):  
Escherichia Coli ◽  
Animal Studies ◽  
Test System ◽  
Toxicity Bioassay ◽  
Commercial Formulation ◽  
E Coli ◽  
Sos Chromotest ◽  
The World ◽  
Genotoxicity Testing ◽  
Daphnia Test

Toxicity and Genotoxicity Testing of Roundup Glyphosate, in the commercial formulation named Roundup, is a broad spectrum herbicide that is one of the most frequently applied pesticides in the world. However, there has been little evidence of Roundup toxicity or genotoxicity. Genotoxicity of glyphosate was carried out using the Escherichia coli SOS chromotest. The glyphosate-induced dose response in the SOS chromotest suggests that glyphosate possesses genotoxic properties. Glyphosate at a 0.2 g/l concentration in toxicity bioassay caused 50% mortality of Daphnia magna (LD50 after 24 h — 0.22 g/l; after 48 h — 0.19 g/l), but 0.25 — 0.5 g/l — 100% death of organisms (LD100 after 24 h — 0.5 g/l; after 48 h — 0.25 g/l). Our results (E. coli SOS chromotest and daphnia test system) together with recent animal studies and epidemiological reports suggest that glyphosate, especially, Roundup possesses both toxic and genotoxic properties.

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