Effects of single dose and regular intake of green tea (Camellia sinensis) on DNA damage, DNA repair, and heme oxygenase-1 expression in a randomized controlled human supplementation study

2014 ◽  
Vol 58 (6) ◽  
pp. 1379-1383 ◽  
Author(s):  
Cyrus K. Ho ◽  
Siu-wai Choi ◽  
Parco M. Siu ◽  
Iris F. F. Benzie
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Single Dose ◽  
Green Tea ◽  
Heme Oxygenase ◽  
Camellia Sinensis ◽  
Heme Oxygenase 1 ◽  
Randomized Controlled ◽  
Regular Intake

scholarly journals Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2−/− mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Roja Barikbin ◽  
Laura Berkhout ◽  
Julia Bolik ◽  
Dirk Schmidt-Arras ◽  
Thomas Ernst ◽  
...  
Keyword(s):  
Dna Damage ◽  
Heme Oxygenase ◽  
Dna Damage Repair ◽  
Heme Oxygenase 1 ◽  
Liver Macrophages ◽  
Damage Repair ◽  
Tumour Initiation

863 HEME OXYGENASE-1 AND CARBON MONOXIDE MODULATE RESPONSES TO DNA DAMAGE AND ARREST TUMOUR GROWTH

2010 ◽  
Vol 9 (2) ◽  
pp. 273-274
Author(s):  
B. Weaiel ◽  
A. Bjartell ◽  
C. Harris ◽  
J. Belcher ◽  
G. Vercellotti ◽  
...  
Keyword(s):  
Dna Damage ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Tumour Growth ◽  
Heme Oxygenase 1

scholarly journals Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells Induced by Interleukin-1βvia Heme Oxygenase-1

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Po-Len Liu ◽  
Jung-Tung Liu ◽  
Hsuan-Fu Kuo ◽  
Inn-Wen Chong ◽  
Chong-Chao Hsieh
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Green Tea ◽  
Vascular Smooth Muscle Cells ◽  
Heme Oxygenase ◽  
Muscle Cells ◽  
Heme Oxygenase 1 ◽  
And Oxidative Stress

Proliferation of vascular smooth muscle cells (VSMCs) triggered by inflammatory stimuli and oxidative stress contributes importantly to atherogenesis. The association of green tea consumption with cardiovascular protection has been well documented in epidemiological observations, however, the underlying mechanisms remain unclear. This study aimed to elucidate the effects of the most active green tea catechin derivative, (−)-epigallocatechin-3-gallate (EGCG), in human aortic smooth muscle cells (HASMCs), focusing particularly on the role of a potent anti-inflammatory and antioxidative enzyme heme oxygenase-1 (HO-1). We found that pretreatment of EGCG dose- and time-dependently induced HO-1 protein levels in HASMCs. EGCG inhibited interleukin- (IL-)1β-induced HASMC proliferation and oxidative stress in a dose-dependent manner. The HO-1 inducer CoPPIX decreased IL-1β-induced cell proliferation, whereas the HO-1 enzyme inhibitor ZnPPIX significantly reversed EGCG-caused growth inhibition in IL-1β-treated HASMCs. At the molecular level, EGCG treatment significantly activated nuclear factor erythroid-2-related factor (Nrf2) transcription activities. These results suggest that EGCG might serve as a complementary and alternative medicine in the treatment of these pathologies by inducing HO-1 expression and subsequently decreasing VSMC proliferation.

Abstract C41: Heme oxygenase‐1 and carbon monoxide modulate responses to DNA damage in prostate cancer

2009 ◽  
Author(s):  
Barbara Wegiel ◽  
Anders Bjartell ◽  
Clair Harris ◽  
John Belcher ◽  
Gregory Vercellotti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

scholarly journals Comparison of catechin profiles in human plasma and urine after single dosing and regular intake of green tea (Camellia sinensis)

2012 ◽  
Vol 109 (12) ◽  
pp. 2199-2207 ◽  
Author(s):  
Shing-Tack Fung ◽  
Cyrus K. Ho ◽  
Siu-Wai Choi ◽  
Wai-Yuen Chung ◽  
Iris F. F. Benzie
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Epigallocatechin Gallate ◽  
Free Form ◽  
Epicatechin Gallate ◽  
Fasting Plasma ◽  
Blood And Urine Samples ◽  
High Level ◽  
Single Dosing ◽  
Regular Intake

Green tea (Camellia sinensis) catechin profiles in plasma and urine following single dosing and regular ingestion of green tea are not clear. We performed a placebo-controlled intervention study with sixteen healthy volunteers to determine changes in total and free catechins after a single dose and following 1 week of twice-daily green tea. Blood and urine samples were collected before (fasting) and after (60 and 120 min for blood; 90 and 180 min for urine) drinking 200 ml of 1·5 % (w/v) green tea or water (n 8 each), and fasting samples were again collected after 7 d of 150 ml of 1 % (w/v) supplemental green tea or water twice daily. After a 4-week washout, subjects were crossed onto the other treatment and procedures repeated. Plasma results at 1 h post-ingestion showed elevated (P< 0·05) mean epigallocatechin gallate (EGCG; 310 (sd 117) nmol/l; all in free form), epigallocatechin (EGC; 192 (sd 67) nmol/l; 30 % free) and epicatechin gallate (ECG; 134 (sd 51) nmol/l; 75 % free). Fasting plasma after 7 d of regular intake showed increased (P< 0·05) EGCG (80 v. 15 nmol/l at baseline) and ECG (120 v. 40 nmol/l), with ≥ 90 % of both in their conjugated forms. Total EGC was < 10 nmol/l. Post-ingestion conjugation and renal loss of EGC and epicatechin were rapid and high, but were negligible for EGCG and ECG. In the green tea consumed, the content was EGCG >EGC >ECG, and the acute plasma response mirrored this. However, after chronic consumption there was almost no EGC found in fasting plasma, some EGCG was present, but a rather high level of ECG was maintained.

scholarly journals AVALIAÇÃO DO USO DO CHÁ VERDE (CAMELLIA SINENSIS) COMO COADJUVANTE NO TRATAMENTO E CONTROLE DA DOENÇA PERIODONTAL: REVISÃO INTEGRATIVA

2021 ◽  
Vol 10 (12) ◽  
pp. 1-21
Author(s):  
Otávio Augusto Pacheco VITÓRIA ◽  
Juliano Milanezi de ALMEIDA ◽  
Vivian Cristina Noronha NOVAES
Keyword(s):  
Periodontal Disease ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Case Reports ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
And Control

Terapias coadjuvantes ao tratamento convencional da periodontite têm sido sugeridas para otimizar os resultados terapêuticos, sendo que o chá verde tem sido proposto por apresentar propriedades benéficas ao tratamento periodontal. Nesse contexto, o objetivo desta revisão integrativa foi avaliar se o uso do chá verde é eficaz no tratamento e controle da periodontite. Para isso, foi realizado um levantamento bibliográfico nas bases de dados PubMed, Lilacs e Cochrane Library, com os descritores green tea, periodontal disease, Camellia sinensis e periodontitis. Foram selecionados artigos na língua inglesa publicados nos últimos 10 anos em que o chá verde deveria ser obrigatoriamente empregado como uma conduta terapêutica e incluídos estudos clínicos randomizados controlados e revisões sistemáticas. Foram excluídos ensaios pré-clínicos, relato de caso clínico, série de relatos clínicos, estudos epidemiológicos, editoriais, opiniões de especialistas, estudo piloto, revisões de literatura, pesquisas com resultados inconcludentes e estudos in-vitro. A busca resultou em 450 artigos dos quais, após aplicação dos critérios de inclusão e exclusão, selecionaram-se 10 artigos, sendo 8 ensaios randomizados controlados e 2 revisões sistemáticas com meta-análise. 6 artigos avaliaram a efetividade do chá verde como colutório oral demonstrando redução da inflamação e do acúmulo de placa bacteriana, 3 estudos associaram o chá verde a raspagem e alisamento radicular, demonstrando diminuição da profundidade, sangramento a sondagem e redução do quadro inflamatório e 1 estudo avaliou a ingestão sistêmica, demonstrando redução na profundidade de sondagem e sangramento. Dessa forma, podemos concluir que o chá verde é eficaz como terapia coadjuvante no tratamento e controle da periodontite. Quando associado à raspagem e ao alisamento radicular e como colutório oral, apresentam-se resultados mais satisfatórios que na forma de ingestão oral.   ASSESSMENT OF GREEN TEA (CAMELLIA SINENSIS) USED AS AN ADJUNCT TO TREATMENT AND CONTROL OF PERIODONTAL DISEASE: INTEGRATIVE REVIEW   Adjunct therapies to conventional treatment for periodontitis have been suggested to optimize therapeutic results; green tea has been suggested because it presents beneficial properties for periodontal treatment. In this context, this integrative review aims at assessing the effectiveness of green tea for periodontitis treatment and control. Thus, bibliographic research was carried out in PubMed, LILACS, and Cochrane Library databases, using the words green tea, periodontal disease, Camelliasinensis, and periodontitis as keywords. Articles in English language issued in the last 10 years were screened, in which green tea was imperatively used as a therapeutic approach and included randomized controlled trials and systematic reviews. Pre-clinical trials, clinical case reports, series of case reports, epidemiological studies, editorials, expert opinions, pilot study, literature review, researches with inconclusive results, and in-vitro studies were excluded. The search resulted in 450 articles in which, after applying inclusion and exclusion criteria, 10 articles were screened, being 10 articles, 8 randomized controlled trials, and 2 systemic reviews and meta-analysis. 6 articles assessed the effectiveness of green tea as mouthwash and presenting a reduction either in inflammation and the accumulation of bacterial plaque, 3 studies associated green tea to scaling and root planing, indicating a decrease in the depth, bleeding when drilling, and reduction in the inflammatory process, 1 study assessed the systemic intake, indicating a reduction in drilling depth and bleeding. Thus, we can conclude that green tea is efficient as adjuvant therapy to the treatment and control of periodontitis. When associated with scaling and root planing, and used as a mouthwash, the results were more satisfactory when it was used as a mouthwash than when it was ingested.   Keywords: Tea. Camelliasinensis. Periodontal Diseases. Periodontology.

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