A Novel Label Free Electrochemical Magnetoimmunosensor for Human Interleukin-6 Quantification in Serum

2018 ◽  
Vol 31 (2) ◽  
pp. 282-292 ◽  
Author(s):  
Mihaela Tertiş ◽  
Gheorghe Melinte ◽  
Bianca Ciui ◽  
Ioan Şimon ◽  
Rareş Ştiufiuc ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Label Free ◽  
Electrochemical Magnetoimmunosensor

An electrochemical impedance sensor for the label-free ultrasensitive detection of interleukin-6 antigen

2013 ◽  
Vol 178 ◽  
pp. 310-315 ◽  
Author(s):  
Ting Yang ◽  
Shun Wang ◽  
Huile Jin ◽  
Weiwei Bao ◽  
Shaoming Huang ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Electrochemical Impedance ◽  
Ultrasensitive Detection ◽  
Label Free ◽  
Impedance Sensor

Label-free electrochemical aptasensor based on gold and polypyrrole nanoparticles for interleukin 6 detection

2017 ◽  
Vol 258 ◽  
pp. 1208-1218 ◽  
Author(s):  
Mihaela Tertiş ◽  
Bianca Ciui ◽  
Maria Suciu ◽  
Robert Săndulescu ◽  
Cecilia Cristea
Keyword(s):  
Interleukin 6 ◽  
Label Free ◽  
Electrochemical Aptasensor ◽  
Polypyrrole Nanoparticles

Label-free electronic detection of interleukin-6 using horizontally aligned carbon nanotubes

2016 ◽  
Vol 90 ◽  
pp. 852-857 ◽  
Author(s):  
Hu Chen ◽  
Teck Kian Choo ◽  
Jingfeng Huang ◽  
Yi Wang ◽  
Yuanjun Liu ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Interleukin 6 ◽  
Label Free ◽  
Aligned Carbon Nanotubes ◽  
Electronic Detection

Highly manufacturable graphene oxide biosensor for sensitive Interleukin-6 detection

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39245-39251 ◽  
Author(s):  
Jingfeng Huang ◽  
Hu Chen ◽  
Wenbin Niu ◽  
Derrick W. H. Fam ◽  
Alagappan Palaniappan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Chemical Vapour Deposition ◽  
Interleukin 6 ◽  
Electrical Resistance ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Label Free ◽  
Reduced Graphene ◽  
Sensor Transducer

Reduced graphene oxide can be used as a sensitive label-free sensor transducer for detection of Interleukin-6 proteins, by overcoming the variable coverage and high electrical resistance, via ethanol Chemical Vapour Deposition (CVD).

scholarly journals Plasmonic nanocrystals on polycarbonate substrates for direct and label-free biodetection of Interleukin-6 in bioengineered 3D skeletal muscles

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Gerardo A Lopez-Muñoz ◽  
Juan M Fernández-Costa ◽  
Maria Alejandra Ortega ◽  
Jordina Balaguer-Trias ◽  
Eduard Martin-Lasierra ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Limit Of Detection ◽  
Culture Media ◽  
Incident Angle ◽  
Wide Field ◽  
Label Free ◽  
Cell Culture Media ◽  
Muscle Tissues ◽  
Label Free Detection ◽  
Potential Benefits

Abstract The development of nanostructured plasmonic biosensors has been widely widespread in the last years, motivated by the potential benefits they can offer in integration, miniaturization, multiplexing opportunities, and enhanced performance label-free biodetection in a wide field of applications. Between them, engineering tissues represent a novel, challenging, and prolific application field for nanostructured plasmonic biosensors considering the previously described benefits and the low levels of secreted biomarkers (≈pM–nM) to detect. Here, we present an integrated plasmonic nanocrystals-based biosensor using high throughput nanostructured polycarbonate substrates. Metallic film thickness and incident angle of light for reflectance measurements were optimized to enhance the detection of antibody–antigen biorecognition events using numerical simulations. We achieved an enhancement in biodetection up to 3× as the incident angle of light decreases, which can be related to shorter evanescent decay lengths. We achieved a high reproducibility between channels with a coefficient of variation below 2% in bulk refractive index measurements, demonstrating a high potential for multiplexed sensing. Finally, biosensing potential was demonstrated by the direct and label-free detection of interleukin-6 biomarker in undiluted cell culture media supernatants from bioengineered 3D skeletal muscle tissues stimulated with different concentrations of endotoxins achieving a limit of detection (LOD) of ≈ 0.03 ng/mL (1.4 pM).

Nanophotonics based label free detection mechanism for real-time monitoring of interleukin-6

Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 9194-9207 ◽  
Author(s):  
Munezza A. Khan ◽  
Mohammad Mujahid ◽  
Say Chye Joachim Loo ◽  
Vidya N. Chamundeswari
Keyword(s):  
Photonic Crystals ◽  
Real Time ◽  
Interleukin 6 ◽  
High Fidelity ◽  
Label Free ◽  
Real Time Monitoring ◽  
Detection Mechanism ◽  
Label Free Detection ◽  
Real Time Detection

Magneto-photonic crystals/MPCs are promising candidates for devising high-fidelity embedded biosensor systems which offer facile & real time detection of diagnostic proteins.

The development of an ultra-sensitive electrochemical immunosensor using a PPyr-NHS functionalized disposable ITO sheet for the detection of interleukin 6 in real human serums

2020 ◽  
Vol 44 (33) ◽  
pp. 14228-14238 ◽  
Author(s):  
Elif Burcu Aydın ◽  
Muhammet Aydın ◽  
Mustafa Kemal Sezgintürk
Keyword(s):  
Interleukin 6 ◽  
Electrochemical Immunosensor ◽  
Sensitive Detection ◽  
Label Free ◽  
Detection Range ◽  
Ito Electrode ◽  
Optimized Conditions

A label-free biosensor based on poly(pyrrole N-hydroxy succinimide) polymer modified ITO electrode was developed for sensitive detection of interleukin 6 antigen. Under optimized conditions, it had a wide detection range (0.03–22.5 pg mL−1).

Label free nano-aptasensor for interleukin-6 in protein-dilute bio fluids such as sweat

2016 ◽  
Vol 8 (17) ◽  
pp. 3440-3444 ◽  
Author(s):  
L. S. Selva Kumar ◽  
Xiao Wang ◽  
Joshua Hagen ◽  
Rajesh Naik ◽  
Ian Papautsky ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Modified Electrode ◽  
Interleukin 6 ◽  
Limit Of Detection ◽  
Label Free ◽  
Artificial Sweat

A sub-pM limit of detection label-free sensor is presented for interleukin-6 based on impedimetric measurement of a gold nanoparticle/aptamer-modified electrode in artificial sweat.

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