Highly manufacturable graphene oxide biosensor for sensitive Interleukin-6 detection

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39245-39251 ◽  
Author(s):  
Jingfeng Huang ◽  
Hu Chen ◽  
Wenbin Niu ◽  
Derrick W. H. Fam ◽  
Alagappan Palaniappan ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Chemical Vapour Deposition ◽  
Interleukin 6 ◽  
Electrical Resistance ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Label Free ◽  
Reduced Graphene ◽  
Sensor Transducer

Reduced graphene oxide can be used as a sensitive label-free sensor transducer for detection of Interleukin-6 proteins, by overcoming the variable coverage and high electrical resistance, via ethanol Chemical Vapour Deposition (CVD).

scholarly journals Growth of Reduced Graphene Oxide

2014 ◽  
Vol 1702 ◽  
Author(s):  
Jingfeng Huang ◽  
Hu Chen ◽  
Derrick Fam ◽  
Steve H. Faulkner ◽  
Wenbin Niu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Electrical Resistance ◽  
Large Scale ◽  
Chemical Vapour ◽  
The Novel ◽  
Production Route ◽  
Reduced Graphene ◽  
Pressure Chemical ◽  
Scalable Production

ABSTRACTReduced graphene oxide (RGO) has the advantage of an aqueous and industrial-scalable production route. However, one of the main limitations that prevent the use of RGO in electronics is the high electrical resistance deviation between fabricated chips. In this article, we present the novel growth of RGO which can bridge the gaps in-between existing flakes and thus reduce the electrical resistance standard deviation from 80.5 % to 16.5 %. The average resistivity of the treated RGO of ∼ 3.8 nm thickness was 200 Ω/square. The study uses an atmospheric-pressure chemical vapour deposition (CVD) system with hydrogen and argon gas bubbling through ethanol before entering the furnace. With a treatment of 2 hours, 100 % of the silicon dioxide substrate was covered with RGO from an initial 65 % coverage. This technology could enable large-scale application of RGO use in practical electronic devices.

Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposite for the ultrasensitive detection of cancer biomarker matrix metalloproteinase-1

The Analyst ◽  
2021 ◽  
Author(s):  
Xinke Liu ◽  
Lu-Yin Lin ◽  
Fu-Yen Tseng ◽  
Yu-Cheng Tan ◽  
Jian Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Matrix Metalloproteinase ◽  
Gold Nanoparticle ◽  
Reduced Graphene Oxide ◽  
Electrochemical Immunosensor ◽  
Ultrasensitive Detection ◽  
Label Free ◽  
Matrix Metalloproteinase 1 ◽  
Reduced Graphene ◽  
P Matrix

Matrix metalloproteinase-1 (MMP-1) is associated with many types of cancers, including oral, colorectal, and brain cancers. This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced...

Carbon-Based Nanomaterials for Drugs Sensing: A Review

2014 ◽  
Vol 807 ◽  
pp. 13-39
Author(s):  
Bavani Kasinathan ◽  
Ruzniza Mohd Zawawi
Keyword(s):  
Carbon Nanotubes ◽  
Graphene Oxide ◽  
Carbon Nanofibers ◽  
Chemical Vapour Deposition ◽  
Vapour Deposition ◽  
Chemical Vapour ◽  
Sensing Applications ◽  
Carbon Based Nanomaterials ◽  
Walled Carbon Nanotubes ◽  
Carbon Based

Carbon-based nanomaterials such as graphene, carbon nanotubes, carbon nanofibers and nanodiamonds have been fascinated considerable attention as promising materials for drug sensing. These materials have tremendous amount of attraction due to some extraordinary features such as excellent electrical and thermal conductivities as well as high mechanical strength. Hence, these nanomaterials have been used extensively in sensor technology in order to achieved desired sensitivities. To date, carbon based nanomaterials have been exploit in the development of various drug sensing due to their simple preparation methods, and cost effectiveness. The aim of this review is to focus upon carbon based nanomaterials predominantly on drugs sensing applications. This review has been written in summary form including properties, fabrication method, and analytical performances.Abbreviation:Au, Gold; CNFs, Carbon Nanofibers; CNTs, Carbon Nanotubes; CVD, Chemical Vapour Deposition; D-, Dextrorotatory enantiomer; D, Dimensional; DNase, deoxyribonuclease; ESD, Electrospinning deposition; GCE, Glassy Carbon Electrode; Gr, Graphene; GrO, Graphene Oxide; ILs, ionic liquids; L-, Levorotatory enantiomer; LOD, Limit of Detection; MTase, Methyltransferases; MW, Microwave; MWCNTs, Multi-walled Carbon nanotubes; NDs, Nanodiamonds; NPs, Nanoparticles; PECVD, Plasma Enhanced Chemical Vapour Deposition; RGO, Reduced Graphene Oxide; SPE, Screen-Printed Electrode; SPR, Surface Plasmon resonance; ssDNA, single-stranded DNA; SWCNTs, Single-walled Carbon nanotubes.

scholarly journals A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

2020 ◽  
Vol 187 (5) ◽  
Author(s):  
Jagriti Sethi ◽  
Michiel Van Bulck ◽  
Ahmed Suhail ◽  
Mina Safarzadeh ◽  
Ana Perez-Castillo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Electrochemical Techniques ◽  
Differential Pulse ◽  
Electrochemical Determination ◽  
Label Free ◽  
Reduced Graphene ◽  
Electrochemically Reduced Graphene Oxide

AbstractA label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.

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