Artificial Biocatalytic Cascade with Three Enzymes in One Pot for Asymmetric Synthesis of Chiral Unnatural Amino Acids

2019 ◽  
Vol 2019 (38) ◽  
pp. 6470-6477 ◽  
Author(s):  
Haisheng Zhou ◽  
Lijun Meng ◽  
Xinjian Yin ◽  
Yayun Liu ◽  
Gang Xu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unnatural Amino Acids ◽  
One Pot

Asymmetric Synthesis of Unnatural Amino Acids and Tamsulosin Chiral Intermediate

2013 ◽  
Vol 43 (21) ◽  
pp. 2892-2897 ◽  
Author(s):  
Veera Reddy Arava ◽  
Srinivasulu Reddy Amasa ◽  
Bharat Kumar Goud Bhatthula ◽  
Laxmi Srinivas Kompella ◽  
Venkata Prasad Matta ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unnatural Amino Acids

scholarly journals A Multistage, One-Pot Procedure Mediated by a Single Catalyst: A New Approach to the Catalytic Asymmetric Synthesis of β-Amino Acids.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Ahmed M. Hafez ◽  
Travis Dudding ◽  
Ty R. Wagerle ◽  
Meha H. Shah ◽  
Andrew E. Taggi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
New Approach ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

ChemInform Abstract: Asymmetric Synthesis of Unnatural Amino Acids and Tamsulosin Chiral Intermediate.

ChemInform ◽  
2013 ◽  
Vol 45 (1) ◽  
pp. no-no
Author(s):  
Veera Reddy Arava ◽  
Srinivasulu Reddy Amasa ◽  
Bharat Kumar Goud Bhatthula ◽  
Laxmi Srinivas Kompella ◽  
Venkata Prasad Matta ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unnatural Amino Acids

Isoxazolinium Salts in Asymmetric Synthesis. 1. Stereoselective Reduction Induced by a 3’-Alkoxy Stereocentre. A New Approach to Polyfunctionalized β-Amino Acids* [1, 2]

2004 ◽  
Vol 59 (4) ◽  
pp. 451-467 ◽  
Author(s):  
Marco Henneböhle ◽  
Pierre-Yves Le Roy ◽  
Matthias Hein ◽  
Rudolf Ehrler ◽  
Volker Jäger
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Catalytic Hydrogenation ◽  
Optically Active ◽  
Side Chain ◽  
Reduction Step ◽  
One Pot ◽  
New Approach ◽  
Stereoselective Reduction

AbstractA new approach to optically active N-methylamino acids is presented, relying on stereoselective reduction of N-methylisoxazolinium salts with a dioxyethyl side-chain. The diastereoselectivity of the reduction step is studied systematically, in comparison with that of respective isoxazolines. A two-step transformation of isoxazolinium salts - with NaBH3(OAc) and subsequent catalytic hydrogenation as well as a one-pot reduction by catalytic hydrogenation led to high (95:5 and 87:13) diastereomeric ratios of protected erythro-N-methylaminopentanetriols. The hydroxyethyl side-chain is elaborated by oxidation to afford the β -N-methylamino acid 37, exemplifying the potential of this strategy.

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