ChemInform Abstract: One-Pot Highly Enantioselective Catalytic Mannich-Type Reactions Between Aldehydes and Stable α-Amido Sulfones: Asymmetric Synthesis of β-Amino Aldehydes and β-Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 41 (17) ◽  
Author(s):  
Luca Deiana ◽  
Gui-Ling Zhao ◽  
Pawel Dziedzic ◽  
Ramon Rios ◽  
Jan Vesely ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
Amino Aldehydes

One-pot highly enantioselective catalytic Mannich-type reactions between aldehydes and stable α-amido sulfones: asymmetric synthesis of β-amino aldehydes and β-amino acids

2010 ◽  
Vol 51 (2) ◽  
pp. 234-237 ◽  
Author(s):  
Luca Deiana ◽  
Gui-Ling Zhao ◽  
Pawel Dziedzic ◽  
Ramon Rios ◽  
Jan Vesely ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
Amino Aldehydes

scholarly journals A Multistage, One-Pot Procedure Mediated by a Single Catalyst: A New Approach to the Catalytic Asymmetric Synthesis of β-Amino Acids.

ChemInform ◽  
2003 ◽  
Vol 34 (48) ◽  
Author(s):  
Ahmed M. Hafez ◽  
Travis Dudding ◽  
Ty R. Wagerle ◽  
Meha H. Shah ◽  
Andrew E. Taggi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
New Approach ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Isoxazolinium Salts in Asymmetric Synthesis. 1. Stereoselective Reduction Induced by a 3’-Alkoxy Stereocentre. A New Approach to Polyfunctionalized β-Amino Acids* [1, 2]

2004 ◽  
Vol 59 (4) ◽  
pp. 451-467 ◽  
Author(s):  
Marco Henneböhle ◽  
Pierre-Yves Le Roy ◽  
Matthias Hein ◽  
Rudolf Ehrler ◽  
Volker Jäger
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Catalytic Hydrogenation ◽  
Optically Active ◽  
Side Chain ◽  
Reduction Step ◽  
One Pot ◽  
New Approach ◽  
Stereoselective Reduction

AbstractA new approach to optically active N-methylamino acids is presented, relying on stereoselective reduction of N-methylisoxazolinium salts with a dioxyethyl side-chain. The diastereoselectivity of the reduction step is studied systematically, in comparison with that of respective isoxazolines. A two-step transformation of isoxazolinium salts - with NaBH3(OAc) and subsequent catalytic hydrogenation as well as a one-pot reduction by catalytic hydrogenation led to high (95:5 and 87:13) diastereomeric ratios of protected erythro-N-methylaminopentanetriols. The hydroxyethyl side-chain is elaborated by oxidation to afford the β -N-methylamino acid 37, exemplifying the potential of this strategy.

Artificial Biocatalytic Cascade with Three Enzymes in One Pot for Asymmetric Synthesis of Chiral Unnatural Amino Acids

2019 ◽  
Vol 2019 (38) ◽  
pp. 6470-6477 ◽  
Author(s):  
Haisheng Zhou ◽  
Lijun Meng ◽  
Xinjian Yin ◽  
Yayun Liu ◽  
Gang Xu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Unnatural Amino Acids ◽  
One Pot
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