Enantioselective Total Synthesis of (-)-Siphonodictyal B and (+)-8-epi-Siphonodictyal B with Phosphatidylinositol 3-Kinase α (PI3Kα) Inhibitory Activity

2016 ◽  
Vol 2016 (34) ◽  
pp. 5659-5666 ◽  
Author(s):  
Takuya Kikuchi ◽  
Koichi Narita ◽  
Ken Saijo ◽  
Chikashi Ishioka ◽  
Tadashi Katoh
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Phosphatidylinositol 3 Kinase ◽  
Enantioselective Total Synthesis ◽  
Phosphatidylinositol 3

scholarly journals Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase

2001 ◽  
Vol 276 (29) ◽  
pp. 27455-27461 ◽  
Author(s):  
Bruce D. Cuevas ◽  
Yiling Lu ◽  
Muling Mao ◽  
Jinyi Zhang ◽  
Ruth LaPushin ◽  
...  
Keyword(s):  
Tyrosine Phosphorylation ◽  
Inhibitory Activity ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms

Molecules ◽  
2011 ◽  
Vol 16 (6) ◽  
pp. 5159-5167 ◽  
Author(s):  
Dexin Kong ◽  
Yanwen Zhang ◽  
Takao Yamori ◽  
Hongquan Duan ◽  
Meihua Jin
Keyword(s):  
Inhibitory Activity ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Enantioselective Total Synthesis of (+)-Rubrobramide, (+)-Talaramide A, and (–)-Berkeleyamide D by a Skeletal Diversification Strategy and Their Amyloid-β Aggregation Inhibitory Activity

2021 ◽  
Author(s):  
Kosaku, III Tanaka ◽  
Kenichi Kobayashi ◽  
Hiroshi Kogen
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Amyloid Β ◽  
Diversification Strategy ◽  
Enantioselective Total Synthesis ◽  
Vinylogous Esters

A unified synthesis of (+)-rubrobramide, (+)-talaramide A, and (–)-berkeleyamide D was achieved from the vinylogous esters by a skeletal diversification strategy based on regioselective 5-exo or 6-endo cyclization. This report...

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis

Diabetes ◽  
1998 ◽  
Vol 47 (2) ◽  
pp. 179-185 ◽  
Author(s):  
R. W. Stevenson ◽  
D. K. Kreutter ◽  
K. M. Andrews ◽  
P. E. Genereux ◽  
E. M. Gibbs
Keyword(s):  
Signaling Pathways ◽  
Glucose Transport ◽  
Insulin Signaling ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

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