Enantioselective Total Synthesis of (+)-Rubrobramide, (+)-Talaramide A, and (–)-Berkeleyamide D by a Skeletal Diversification Strategy and Their Amyloid-β Aggregation Inhibitory Activity

2021 ◽  
Author(s):  
Kosaku, III Tanaka ◽  
Kenichi Kobayashi ◽  
Hiroshi Kogen
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Amyloid Β ◽  
Diversification Strategy ◽  
Enantioselective Total Synthesis ◽  
Vinylogous Esters

A unified synthesis of (+)-rubrobramide, (+)-talaramide A, and (–)-berkeleyamide D was achieved from the vinylogous esters by a skeletal diversification strategy based on regioselective 5-exo or 6-endo cyclization. This report...

Total Synthesis and Amyloid β Aggregation Inhibitory Activity of (−)-L-755,807

2019 ◽  
Vol 77 (7) ◽  
pp. 673-683 ◽  
Author(s):  
Kosaku Tanaka III ◽  
Kenichi Kobayashi ◽  
Hiroshi Kogen
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Amyloid Β

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

scholarly journals Enantioselective Total Synthesis of (+)‐Garsubellin A

2021 ◽  
Author(s):  
Dongseok Jang ◽  
Minchul Choi ◽  
Jinglong Chen ◽  
Chulbom Lee
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective Total Synthesis of ( – )‐Spiroxins A, C and D

2021 ◽  
Author(s):  
Xin Shu ◽  
Chong-Chong Chen ◽  
Tao Yu ◽  
Jiayi Yang ◽  
Xiangdong Hu
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C

2021 ◽  
Vol 67 ◽  
pp. 152895
Author(s):  
Shu Takahashi ◽  
Aoi Kimishima ◽  
Tomoyasu Hirose ◽  
Takeshi Yamada ◽  
Akihiro Sugawara ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective total synthesis of sesquiterpenoid phellilane L and its diastereomer

Tetrahedron ◽  
2021 ◽  
Vol 87 ◽  
pp. 132110
Author(s):  
Gullapalli Kumaraswamy ◽  
Vankudoth Ramesh ◽  
Swargam Vijaykumar
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

scholarly journals Total Synthesis and Inhibitory Activity against Gelatinase B of YL 01869P.

1995 ◽  
Vol 48 (1) ◽  
pp. 87-88 ◽  
Author(s):  
KAZUHIKO TAMAKI ◽  
AKI MATSUBARA ◽  
KAZUHIKO TANZAWA ◽  
YUKIO SUGIMURA
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Gelatinase B

A concise enantioselective total synthesis of rhizoxin D

2002 ◽  
Vol 43 (3) ◽  
pp. 493-497 ◽  
Author(s):  
Ian S. Mitchell ◽  
Gerald Pattenden ◽  
Jeffrey P. Stonehouse
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis ◽  
Rhizoxin D
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