scholarly journals Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms

Molecules ◽  
2011 ◽  
Vol 16 (6) ◽  
pp. 5159-5167 ◽  
Author(s):  
Dexin Kong ◽  
Yanwen Zhang ◽  
Takao Yamori ◽  
Hongquan Duan ◽  
Meihua Jin
Keyword(s):  
Inhibitory Activity ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase

2001 ◽  
Vol 276 (29) ◽  
pp. 27455-27461 ◽  
Author(s):  
Bruce D. Cuevas ◽  
Yiling Lu ◽  
Muling Mao ◽  
Jinyi Zhang ◽  
Ruth LaPushin ◽  
...  
Keyword(s):  
Tyrosine Phosphorylation ◽  
Inhibitory Activity ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Effects of rifampin on the pharmacokinetics of copanlisib, a novel pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor in cancer patients.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e14559-e14559
Author(s):  
Anna Spreafico ◽  
Michael B. Sawyer ◽  
Lillian L. Siu ◽  
Funan Huang ◽  
Susanne Reschke ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Pi3k Inhibitor ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway

2011 ◽  
Vol 48 (4) ◽  
pp. 720-727 ◽  
Author(s):  
Hun-Jung Park ◽  
Suk Jun Lee ◽  
Sang-Hoon Kim ◽  
Jihye Han ◽  
Joonbeom Bae ◽  
...  
Keyword(s):  
Pi3k Pathway ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals The p85α Subunit of Class IA Phosphatidylinositol 3-Kinase Regulates the Expression of Multiple Genes Involved in Osteoclast Maturation and Migration

2008 ◽  
Vol 28 (23) ◽  
pp. 7182-7198 ◽  
Author(s):  
Veerendra Munugalavadla ◽  
Sasidhar Vemula ◽  
Emily Catherine Sims ◽  
Subha Krishnan ◽  
Shi Chen ◽  
...  
Keyword(s):  
Full Length ◽  
Mitogen Activated Protein Kinase ◽  
Class I ◽  
Pcr Analysis ◽  
Tartrate Resistant Acid Phosphatase ◽  
Wild Type ◽  
Phosphatidylinositol 3 Kinase ◽  
And Migration ◽  
Phosphatidylinositol 3

ABSTRACT Intracellular signals involved in the maturation and function of osteoclasts are poorly understood. Here, we demonstrate that osteoclasts express multiple regulatory subunits of class IA phosphatidylinositol 3-kinase (PI3-K) although the expression of the full-length form of p85α is most abundant. In vivo, deficiency of p85α results in a significantly greater number of trabeculae and significantly lower spacing between trabeculae as well as increased bone mass in both males and females compared to their sex-matched wild-type controls. Consistently, p85α−/− osteoclast progenitors show impaired growth and differentiation, which is associated with reduced activation of Akt and mitogen-activated protein kinase extracellular signal-regulated kinase 1 (Erk1)/Erk2 in vitro. Furthermore, a significant reduction in the ability of p85α−/− osteoclasts to adhere to as well as to migrate via integrin αvβ3 was observed, which was associated with reduced bone resorption. Microarray as well as quantitative real-time PCR analysis of p85α−/− osteoclasts revealed a significant reduction in the expression of several genes associated with the maturation and migration of osteoclasts, including microphathalmia-associated transcription factor, tartrate-resistant acid phosphatase, cathepsin K, and β3 integrin. Restoring the expression of the full-length form of p85α but not the version with a deletion of the Src homology-3 domain restored the maturation of p85α−/− osteoclasts to wild-type levels. These results highlight the importance of the full-length version of the p85α subunit of class IA PI3-K in controlling multiple aspects of osteoclast functions.

scholarly journals Class I and III Phosphatidylinositol 3′-Kinase Play Distinct Roles in TLR Signaling Pathway

2006 ◽  
Vol 176 (10) ◽  
pp. 5943-5949 ◽  
Author(s):  
Cheng-Chin Kuo ◽  
Wen-Ting Lin ◽  
Chi-Ming Liang ◽  
Shu-Mei Liang
Keyword(s):  
Signaling Pathway ◽  
Class I ◽  
Phosphatidylinositol 3 Kinase ◽  
Tlr Signaling ◽  
Tlr Signaling Pathway ◽  
Phosphatidylinositol 3

scholarly journals The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α

1998 ◽  
Vol 273 (40) ◽  
pp. 25987-25995 ◽  
Author(s):  
Sarah J. Turner ◽  
Jan Domin ◽  
Michael D. Waterfield ◽  
Stephen G. Ward ◽  
John Westwick
Keyword(s):  
Class Ii ◽  
Class I ◽  
Chemotactic Peptide ◽  
Phosphatidylinositol 3 Kinase ◽  
Cc Chemokine ◽  
Phosphatidylinositol 3
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