First Enantioselective Synthesis of Surinamensinol B and a Non-Natural Polysphorin Analogue by a Two-Stereocentered Hydrolytic Kinetic Resolution

2015 ◽  
Vol 2015 (33) ◽  
pp. 7344-7351 ◽  
Author(s):  
Komal G. Lalwani ◽  
Arumugam Sudalai
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Hydrolytic Kinetic Resolution

A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil

2017 ◽  
Vol 41 (2) ◽  
pp. 824-829 ◽  
Author(s):  
Mohammad Mujahid ◽  
Jambu Subramanian ◽  
Viswanadh Nalla ◽  
Murugesan Sasikumar ◽  
Sunita Sharad Kunte ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Kinetic Resolution ◽  
Channel Blocker ◽  
Enantioselective Synthesis ◽  
Mitsunobu Reaction ◽  
Hydrolytic Kinetic Resolution ◽  
Key Steps

We report a simple enantioselective synthesis of bepridil enantiomers employing hydrolytic kinetic resolution and the Mitsunobu reaction as key steps.

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