ChemInform Abstract: An Enantioselective Synthesis of (R)-2-Amino-1-hydroxyethylphosphonic Acid (III) by Hydrolytic Kinetic Resolution of (.+-.)-Diethyl Oxiranephosphonate.

ChemInform ◽  
2010 ◽  
Vol 30 (44) ◽  
pp. no-no
Author(s):  
Peter B. Wyatt ◽  
Peter Blakskjaer
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Hydrolytic Kinetic Resolution

A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil

2017 ◽  
Vol 41 (2) ◽  
pp. 824-829 ◽  
Author(s):  
Mohammad Mujahid ◽  
Jambu Subramanian ◽  
Viswanadh Nalla ◽  
Murugesan Sasikumar ◽  
Sunita Sharad Kunte ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Kinetic Resolution ◽  
Channel Blocker ◽  
Enantioselective Synthesis ◽  
Mitsunobu Reaction ◽  
Hydrolytic Kinetic Resolution ◽  
Key Steps

We report a simple enantioselective synthesis of bepridil enantiomers employing hydrolytic kinetic resolution and the Mitsunobu reaction as key steps.

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