New Highly Diastereoselective Perkin/Michael Addition Domino Reaction between Homophthalic Anhydride and Aromatic Aldehydes: A Facile Approach to Blue-Fluorescent Dibenzo[c,h]chromenones

2010 ◽  
Vol 2011 (2) ◽  
pp. 377-384 ◽  
Author(s):  
Milen G. Bogdanov ◽  
Yavor Mitrev ◽  
Ioannis Tiritiris
Keyword(s):  
Michael Addition ◽  
Aromatic Aldehydes ◽  
Domino Reaction ◽  
Homophthalic Anhydride

scholarly journals A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION

2019 ◽  
Vol 9 (4-A) ◽  
pp. 271-279
Author(s):  
SEKAR SILAMBU SILAMBARASAN ◽  
A. Jamal Abdul Nasser
Keyword(s):  
Single Crystal ◽  
13C Nmr ◽  
Michael Addition ◽  
Addition Reaction ◽  
Aromatic Aldehydes ◽  
Simple Approach ◽  
Domino Reaction ◽  
Single Crystal Xrd ◽  
Michael Addition Reaction ◽  
Benign Synthesis

A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.  Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.

scholarly journals Synthesis of 3,3′-arylmethylidenebis-4-hydroxycoumarin derivatives catalysed by KF-montmorillonite

2007 ◽  
Vol 2007 (10) ◽  
pp. 561-562 ◽  
Author(s):  
Nan Wu ◽  
Xinnian Li ◽  
Xin Xu ◽  
Daqing Shi
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Aromatic Aldehydes ◽  
Michael Addition Reaction ◽  
The Michael Addition

3,3′-Arylmethylidenebis-4-hydroxycoumarins derivatives have been synthesised in good yields by the Michael addition reaction of aromatic aldehydes with 4-hydroxycoumarin in DMF catalysed by KF-montmorillonite.

Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts

2018 ◽  
Vol 16 (48) ◽  
pp. 9314-9318 ◽  
Author(s):  
Alexey A. Kostenko ◽  
Alexander S. Kucherenko ◽  
Andrey N. Komogortsev ◽  
Boris V. Lichitsky ◽  
Sergei G. Zlotin
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Kojic Acid ◽  
Domino Reaction ◽  
Asymmetric Michael Addition

An efficient C2-symmetric bifunctional tertiary amine–squaramide organocatalyst for the asymmetric Michael addition/hemiketalization domino reaction of kojic acid derivatives with β,γ-unsaturated α-ketoesters has been designed.

scholarly journals Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes

2012 ◽  
Vol 8 ◽  
pp. 1839-1843 ◽  
Author(s):  
Jing Sun ◽  
Hong Gao ◽  
Qun Wu ◽  
Chao-Guo Yan
Keyword(s):  
Aromatic Aldehydes ◽  
Domino Reaction ◽  
Facile Synthesis ◽  
Methyl Propiolate ◽  
Toluenesulfonic Acid ◽  
Povarov Reaction

In the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in situ generated β-enamino ester with the in situ formed aromatic imine.

Unique Michael Addition-Initiated Domino Reaction for the Stereoselective Synthesis of Functionalized Macrolactones from α-Nitroketones in Water†

2005 ◽  
Vol 7 (11) ◽  
pp. 2197-2200 ◽  
Author(s):  
Giorgio Giorgi ◽  
Sonia Miranda ◽  
Pilar López-Alvarado ◽  
Carmen Avendaño ◽  
Jean Rodriguez ◽  
...  
Keyword(s):  
Michael Addition ◽  
Stereoselective Synthesis ◽  
Domino Reaction

scholarly journals Synthesis and Molecular Docking Studies of N,N-Dimethyl Arylpyranopyrimidinedione Derivatives

SynOpen ◽  
2022 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
Sivan Velmathi ◽  
Srinivasan Prabhakaran
Keyword(s):  
Molecular Docking ◽  
Reaction Mechanism ◽  
Binding Energy ◽  
Michael Addition ◽  
Barbituric Acid ◽  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Docking Studies ◽  
Reaction Sequence ◽  
Kinesin Eg5

AbstractThe synthesis of N,N-dimethyl arylpyranopyrimidinedione derivatives from aromatic aldehydes, N-methyl-1-(methylthio)-2-nitroethamine (NMSM) and 1,3-dimethyl barbituric acid, in the presence of piperidine as a catalyst, is reported. The reaction mechanism involves a Knoevenagel condensation, followed by Michael addition and intramolecular O-cyclization reaction sequence. The synthesized compounds were docked with human kinesin Eg5 protein to calculate binding energy, inhibition constant and H-bond interaction. All the compounds show good binding affinity towards the protein, with significant docking score.

scholarly journals Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

2020 ◽  
Vol 18 (41) ◽  
pp. 8395-8401
Author(s):  
Greta Colombo Dugoni ◽  
Alessandro Sacchetti ◽  
Andrea Mele
Keyword(s):  
Michael Addition ◽  
Deep Eutectic Solvent ◽  
Aromatic Aldehydes ◽  
Henry Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Mw Irradiation

1,3-Dinitropropane derivatives were obtained in a simple one-pot procedure from nitromethane and aromatic aldehydes by combining MW irradiation and the use of DES as both catalyst and solvent.

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