ChemInform Abstract: Base-Promoted Domino Reaction for the Synthesis of 2,3-Disubstituted Indoles from 2-Aminobenzaldehyde/2-Amino Aryl Ketones, Tosylhydrazine, and Aromatic Aldehydes.

ChemInform ◽  
2016 ◽  
Vol 47 (47) ◽  
Author(s):  
Yan-Dong Wu ◽  
Jun-Rui Ma ◽  
Wen-Ming Shu ◽  
Kai-Lu Zheng ◽  
An-Xin Wu
Keyword(s):  
Aromatic Aldehydes ◽  
Domino Reaction ◽  
Aryl Ketones

Base-promoted domino reaction for the synthesis of 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes

Tetrahedron ◽  
2016 ◽  
Vol 72 (32) ◽  
pp. 4821-4826 ◽  
Author(s):  
Yan-Dong Wu ◽  
Jun-Rui Ma ◽  
Wen-Ming Shu ◽  
Kai-Lu Zheng ◽  
An-Xin Wu
Keyword(s):  
Aromatic Aldehydes ◽  
Domino Reaction ◽  
Aryl Ketones

scholarly journals Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes

2012 ◽  
Vol 8 ◽  
pp. 1839-1843 ◽  
Author(s):  
Jing Sun ◽  
Hong Gao ◽  
Qun Wu ◽  
Chao-Guo Yan
Keyword(s):  
Aromatic Aldehydes ◽  
Domino Reaction ◽  
Facile Synthesis ◽  
Methyl Propiolate ◽  
Toluenesulfonic Acid ◽  
Povarov Reaction

In the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in situ generated β-enamino ester with the in situ formed aromatic imine.

scholarly journals A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION

2019 ◽  
Vol 9 (4-A) ◽  
pp. 271-279
Author(s):  
SEKAR SILAMBU SILAMBARASAN ◽  
A. Jamal Abdul Nasser
Keyword(s):  
Single Crystal ◽  
13C Nmr ◽  
Michael Addition ◽  
Addition Reaction ◽  
Aromatic Aldehydes ◽  
Simple Approach ◽  
Domino Reaction ◽  
Single Crystal Xrd ◽  
Michael Addition Reaction ◽  
Benign Synthesis

A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.  Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.

The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

2010 ◽  
Vol 51 (27) ◽  
pp. 3571-3574 ◽  
Author(s):  
Lu Lin ◽  
Yi Li ◽  
Wenting Du ◽  
Wei-Ping Deng
Keyword(s):  
Cross Coupling ◽  
Aromatic Aldehydes ◽  
Aryl Ketones ◽  
Benzyl Halides

An Efficient Synthesis of Pyrano[c]chromenediones and [1,3]Dioxolo[g]chromeneones Catalyzed by Nickel(II) Chromite Nanoparticles Through a Three-Component Domino Reaction

2021 ◽  
Vol 24 ◽  
Author(s):  
Bahareh Saeedi ◽  
Shahrzad Abdolmohammadi ◽  
Zohreh Mirjafary ◽  
Reza Kia-Kojoori
Keyword(s):  
Condensation Reaction ◽  
Reaction Times ◽  
Catalytic Efficiency ◽  
Aromatic Aldehydes ◽  
13C Nmr Spectroscopy ◽  
Recyclable Catalyst ◽  
Lewis Base ◽  
Domino Reaction ◽  
Elemental Analyses ◽  
High Yields

Background: The importance of fused chromene motifs in bioactive compounds highlighted the current research to explore novel methods for the construction of these heterocyclic scaffolds. Regarding the attractive features of developing novel methodological approaches in the presence of heterogeneous nanocatalysts, we will try to synthesize 4-aryl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones and 8-aryl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene-6-ones through this method. Objective: The aim of the present research was to prove the catalytic efficiency of the synthesized nickel(II) chromite nanoparticles (NiCr2O4 NPs) as bifunctional Lewis acid-Lewis base catalyst in the synthesis of pyrano[c]chromenediones and [1,3]dioxolo[g]chromeneones. Methods: Pyrano[c]chromenediones and [1,3]dioxolo[g]chromeneones were conveniently prepared from a three-component condensation reaction between aromatic aldehydes, meldrum’s acid, and active methylene compounds including 4-hydroxycoumarin or 3,4-methylenedioxyphenol using NiCr2O4 NPs as an efficient, easily obtained, and recyclable catalyst, under ethanol-drop grinding at room temperature. The synthesized compounds were characterized by IR, 1H and 13C NMR spectroscopy, and also by elemental analyses. Results: A number of 4-aryl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones and 8-aryl-7,8-dihydro-6H-[1,3]dioxolo[4,5-g]chromene-6-ones were effectively synthesized as target compounds in high yields. Conclusion: This study provides a simple, inexpensive and NiCr2O4 NPs catalyzed route to synthesis pyrano[c]chromenediones and [1,3]dioxolo[g]chromeneones in high yields. The reaction offers several benefits including simple experimental procedures, higher yields, shorter reaction times and use of easily obtained and recyclable catalyst compared with previously reported methods and has a great foreground of development.

Comparison of different reducing systems in the synthesis of functionally substituted benzylamines from alkyl aryl ketones and aromatic aldehydes

2010 ◽  
Vol 46 (7) ◽  
pp. 1021-1028 ◽  
Author(s):  
D. M. Musatov ◽  
E. V. Starodubtseva ◽  
O. V. Turova ◽  
D. V. Kurilov ◽  
M. G. Vinogradov ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Alkyl Aryl ◽  
Aryl Ketones
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