Efficient Artificial Nucleases for Mediating DNA Cleavage Based on Tuning the Steric Effect in the Pyridyl Derivatives of Tripod Tetraamine-Cobalt(II) Complexes

2018 ◽  
Vol 2018 (20-21) ◽  
pp. 2322-2338 ◽  
Author(s):  
Sebastian Doniz Kettenmann ◽  
Febee R. Louka ◽  
Elise Marine ◽  
Roland C. Fischer ◽  
Franz A. Mautner ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Steric Effect ◽  
Artificial Nucleases ◽  
Derivatives Of

ChemInform Abstract: Derivatives of Benzimidazole Pharmacophore: Synthesis, Anticonvulsant, Antidiabetic and DNA Cleavage Studies.

ChemInform ◽  
2010 ◽  
Vol 41 (33) ◽  
pp. no-no
Author(s):  
Ramya V. Shingalapur ◽  
Kallappa M. Hosamani ◽  
Rangappa S. Keri ◽  
Mallinath H. Hugar
Keyword(s):  
Dna Cleavage ◽  
Derivatives Of

scholarly journals THE STEREOCHEMISTRY OF HALOGEN DISPLACEMENT BY NITRATE ION RACEMIZATION AND RETENTION OF CONFIGURATION IN THE SYNTHESIS OF DINITRATE ESTERS

1965 ◽  
Vol 43 (6) ◽  
pp. 1656-1660 ◽  
Author(s):  
L. D. Hayward ◽  
M. Jackson ◽  
I. G. Csizmadia
Keyword(s):  
Silver Nitrate ◽  
Steric Effect ◽  
Heterogeneous Reaction ◽  
Ion Pair ◽  
Alkyl Halides ◽  
Preferential Formation ◽  
Carbonium Ion ◽  
Carbonium Ions ◽  
And Inversion ◽  
Derivatives Of

The reaction of silver nitrate in dry acetonitrile with 2,5-dideoxy-2,5-diiodo-1,4;3,6-dianhydro-L-iditol resulted in formation of the dinitrate esters of the 1,4;3,6-dianhydrides of D-mannitol, D-glucitol, and L-iditol. Similarly both endo- and exo-nitrato groups were introduced in displacement of the endo-halogen in the 2-deoxy-2-iodo-5-O-acetyl and 2-deoxy-2-iodo-5-O-p-toluenesulfonyl derivatives of 1,4;3,6-dianhydro-L-iditol. Since both types of nitrato groups were stable to silver nitrate, the racemization occurred during the displacement and was attributed to formation of cyclic carbonium ion intermediates. The steric effect of the adjacent ring in the carbonium ions apparently suppressed the termolecular, ion-pair mechanism previously established for the metathesis of acyclic alkyl halides and caused preferential formation of the exo-nitrato derivatives.The heterogeneous reaction of meso-dibromostilbene with silver nitrate in acetic acid or acetonitrile gave meso-dihydrobenzoin dinitrate with overall retention of configuration. This result could be most readily reconciled with the contrasting sequence of retention and inversion previously reported for meso- and dl-2,3-dibromobutane if participation of neighboring phenyl groups occurred in the second displacement step.

Fingerprinting bacterial chromosomal DNA with restriction endonuclease EcoRI: comparison of Rhizobium spp. and identification of mutants

1979 ◽  
Vol 25 (7) ◽  
pp. 803-807 ◽  
Author(s):  
Jonathan R. Mielenz ◽  
L. E. Jackson ◽  
F. O'Gara ◽  
K. T. Shanmugam
Keyword(s):  
Restriction Endonuclease ◽  
Dna Cleavage ◽  
Rhizobium Trifolii ◽  
Chromosomal Dna ◽  
Mutant Strains ◽  
Restriction Endonuclease Ecori ◽  
Endonuclease Ecori ◽  
Cellular Dna ◽  
Derivatives Of ◽  
Japonicum Strain

Total cellular DNA from Rhizobium trifolii, R. meliloti, and R. japonicum strains 110 and 117 were prepared. DNA fragments generated with restriction endonuclease EcoRI from these DNA samples were compared in agarose gels after electrophoresis. DNA cleavage patterns generated from R. japonicum strain 110, R. trifolii, and R. meliloti were clearly distinguishable from each other. Restriction endonuclease cleavage patterns of DNA from R. japonicum strain 110 and presumptive R. trifolii mutant strains that nodulate soybean were found to be similar. Rhizobium trifolii mutant strains were also lysed by a phage specific for R. japonicum strain 110. These results show that "R. trifolii mutant strains" are indeed derivatives of R. japonicum strain 110 and not R. trifolii.

Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies

2010 ◽  
Vol 45 (5) ◽  
pp. 1753-1759 ◽  
Author(s):  
Ramya V. Shingalapur ◽  
Kallappa M. Hosamani ◽  
Rangappa S. Keri ◽  
Mallinath H. Hugar
Keyword(s):  
Dna Cleavage ◽  
Derivatives Of

DNA Cleavage by Topoisomerase I in the Presence of Indolocarbazole Derivatives of Rebeccamycin†

Biochemistry ◽  
1997 ◽  
Vol 36 (13) ◽  
pp. 3917-3929 ◽  
Author(s):  
Christian Bailly ◽  
Jean-François Riou ◽  
Pierre Colson ◽  
Claude Houssier ◽  
Elisabète Rodrigues-Pereira ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Derivatives Of

ChemInform Abstract: Analgesic, anti-Pyretic and DNA Cleavage Studies of Novel Pyrimidine Derivatives of Coumarin Moiety.

ChemInform ◽  
2010 ◽  
Vol 41 (41) ◽  
pp. no-no
Author(s):  
Rangappa S. Keri ◽  
Kallappa M. Hosamani ◽  
Ramya V. Shingalapur ◽  
Mallinath H. Hugar
Keyword(s):  
Dna Cleavage ◽  
Pyrimidine Derivatives ◽  
Derivatives Of

Kinetic properties of the chelating derivatives of spheric cellulose

1986 ◽  
Vol 51 (9) ◽  
pp. 1903-1909 ◽  
Author(s):  
Věnceslava Tokarová ◽  
Oldřich Tokar ◽  
Jaromír Kareš
Keyword(s):  
Diffusion Coefficient ◽  
Functional Groups ◽  
Total Mass ◽  
Steric Effect ◽  
Ion Exchanger ◽  
Substantial Decrease ◽  
Exponential Dependence ◽  
Kinetic Properties ◽  
Sorption Rate ◽  
Derivatives Of

The steric effect of the functional groups on the kinetic properties of the chelating cellulose ion exchanger OSTSORB SALICYL is demonstrated. The exponential dependence was found between the diffusion coefficient and the concentration of the ion-exchanging functional groups and, together with its total mass capacity and its content of water, it has been used for the estimation of the sorbent kinetic properties. Moreover, the results obtained show that the attempt to achieve the highest possible capacity of the ion exchanger can lead to a substantial decrease of the sorption rate.

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