ChemInform Abstract: Analgesic, anti-Pyretic and DNA Cleavage Studies of Novel Pyrimidine Derivatives of Coumarin Moiety.

ChemInform ◽  
2010 ◽  
Vol 41 (41) ◽  
pp. no-no
Author(s):  
Rangappa S. Keri ◽  
Kallappa M. Hosamani ◽  
Ramya V. Shingalapur ◽  
Mallinath H. Hugar
Keyword(s):  
Dna Cleavage ◽  
Pyrimidine Derivatives ◽  
Derivatives Of

Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety

2010 ◽  
Vol 45 (6) ◽  
pp. 2597-2605 ◽  
Author(s):  
Rangappa S. Keri ◽  
Kallappa M. Hosamani ◽  
Ramya V. Shingalapur ◽  
Mallinath H. Hugar
Keyword(s):  
Dna Cleavage ◽  
Pyrimidine Derivatives ◽  
Derivatives Of

Correction of pyrimidine derivatives of immunologic activity of the organism and external respiration function for prevention of the lingering course of acute pneumonia

1993 ◽  
Vol 74 (3) ◽  
pp. 193-197
Author(s):  
Yu. D. Slabnov ◽  
D. A. Valimukhametova ◽  
A. P. Tsibulkin ◽  
R. F. Khamitov
Keyword(s):  
Side Effects ◽  
Combined Treatment ◽  
External Respiration ◽  
Pyrimidine Derivatives ◽  
Acute Pneumonia ◽  
Cellular And Humoral Immunity ◽  
Immunologic Activity ◽  
Derivatives Of ◽  
Respiration Function ◽  
Stabilization Period

The effect of xymedon on immunologic indices and external respiration function in combined treatment of patients with acute pnemonia is studied. The use of xymedon in the presence of basis therapy in patients with lingering pneumonia with reduced immunologic reactivity exerts a stimulating effect on the indices of cellular and humoral immunity. This effect is revealed in the stabilization period of pneumonia accompanied by positive clinicoroentgenologic shifts, provides a higher increase of the indices of external respiration function, reduces the terms of recovery of patients. Xymedon does not cause side effects. The drug may be recommended for a wider use in the clinic in patients with unspecific diseases of the lungs.

Pyrimidine Derivatives of N-Acetylguanidine: Novel Inhibitors of Sodium-Hydrogen Exchanger 1

Heterocycles ◽  
2018 ◽  
Vol 96 (6) ◽  
pp. 1101
Author(s):  
Alexander Ozerov ◽  
Mikhail Novikov ◽  
Alexander Spasov ◽  
Igor Iezhitsa ◽  
Natalia Gurova ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
Sodium Hydrogen ◽  
Sodium Hydrogen Exchanger ◽  
Derivatives Of

scholarly journals PYRIMIDINES AS POTENT CYTOTOXIC AND ANTI-INFLAMMATORY AGENTS

2017 ◽  
Vol 10 (6) ◽  
pp. 237 ◽  
Author(s):  
Ishwar Bhat K ◽  
Abhishek Kumar
Keyword(s):  
Acetic Acid ◽  
Cytotoxic Activity ◽  
Glacial Acetic Acid ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Cytotoxic Agents ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Derivatives Of

Objective: Many derivatives of pyrimidine are known for the broad-spectrum biological activities such as antimicrobial, antitumor, antibacterial, antitubercular, anti-inflammatory, and cytotoxic activity. Chalcones with an enone group show potent pharmacological activities such as antiinflammatory, antibacterial, antifungal, and antimalarial activity. A series of pyrimidines from chalcones have been synthesized and screened for anti-inflammatory and cytotoxic activity studies.Methods: Chalcones [1-(4-nitrophenyl)-3-substituted-phenylprop-2-en-1-one] were synthesized from various substituted aldehydes with 4-nitroacetophenone and cyclized with urea and glacial acetic acid to give pyrimidine derivatives [4-(4-nitrophenyl)-6-substituted-phenylpyrimidin-2-ol].Results: Anti-inflammatory and cytotoxic activity studies revealed that some of the synthesized compounds have shown significant activity.Conclusion: The observed results proved that pyrimidines are found to be interesting lead molecules for the synthesis of anti-inflammatory and cytotoxic agents

The synthesis of peptides containing purine and pyrimidine derivatives of DL-alanine

Tetrahedron ◽  
1974 ◽  
Vol 30 (16) ◽  
pp. 2755-2759 ◽  
Author(s):  
M.T. Doel ◽  
A.S. Jones ◽  
R.T. Walker
Keyword(s):  
Pyrimidine Derivatives ◽  
Derivatives Of
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