scholarly journals Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery

2017 ◽  
Vol 2017 (12) ◽  
pp. 1586-1595 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Min Guo ◽  
Jin-Gang Liu
Author(s):  
Brandon Heilman ◽  
Pradip K. Mascharak

The discovery of nitric oxide (NO) as a signalling molecule in various physiological and pathological pathways has spurred research in the design of exogenous NO donors as drugs. In recent years, metal nitrosyls (NO complexes of metals) have been investigated as NO-donating agents. Results from our laboratory during the past few years have demonstrated that metal nitrosyls derived from designed ligands can deliver NO under the total control of light of various frequencies. Careful incorporation of these photoactive nitrosyls into polymer matrices has afforded a set of nitrosyl–polymer composites that can be used to make such NO delivery site-specific. The composite materials have shown excellent antineoplastic and antimicrobial actions in several in vitro experiments. This review highlights our key results in the context of recent developments in this area of NO donors that deliver NO on demand.


Nitric Oxide ◽  
2004 ◽  
Vol 11 (3) ◽  
pp. 263-272 ◽  
Author(s):  
Amedea Barozzi Seabra ◽  
Gabriela Freitas Pereira de Souza ◽  
Lilian Lúcia da Rocha ◽  
Marcos Nogueira Eberlin ◽  
Marcelo Ganzarolli de Oliveira

ACS Nano ◽  
2016 ◽  
Vol 10 (4) ◽  
pp. 4199-4208 ◽  
Author(s):  
Hyung Woo Choi ◽  
Jihoon Kim ◽  
Jinhwan Kim ◽  
Yonghwi Kim ◽  
Hyun Beom Song ◽  
...  

Cardiology ◽  
2011 ◽  
Vol 118 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Kyomars Abbasi ◽  
Keivan Shalileh ◽  
Maryam Sotudeh Anvari ◽  
Shahram Rabbani ◽  
Abolfazl Mahdanian ◽  
...  

Author(s):  
Zhi Lin ◽  
Rosana V. Pinto ◽  
Carlos Henriques ◽  
Fernando Antunes ◽  
João Pires ◽  
...  

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