scholarly journals Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines

2011 ◽  
Vol 02 (01) ◽  
pp. 40-53 ◽  
Author(s):  
Yoshiko Yasuda ◽  
Yasuhiro Maeda ◽  
Satoshi Hara ◽  
Motoyoshi Tanaka ◽  
Eiji Koike ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Erythropoietin Receptor ◽  
Soluble Form ◽  
Constitutively Active

Inhibition of Akt/FOXO3a signaling by constitutively active FOXO3a suppresses growth of follicular thyroid cancer cell lines

2012 ◽  
Vol 314 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Zhen-Yu Hong ◽  
Hyeon Jung Lee ◽  
Dong Yeob Shin ◽  
Suk Kyoung Kim ◽  
MiRan Seo ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Thyroid Cancer Cell ◽  
Follicular Thyroid Cancer ◽  
Thyroid Cancer Cell Lines ◽  
Constitutively Active

scholarly journals mRTVP-1, a Novel p53 Target Gene with Proapoptotic Activities

2002 ◽  
Vol 22 (10) ◽  
pp. 3345-3357 ◽  
Author(s):  
Chengzhen Ren ◽  
Likun Li ◽  
Alexei A. Goltsov ◽  
Terry L. Timme ◽  
Salahaldin A. Tahir ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cell Lines ◽  
Cancer Cell ◽  
Target Gene ◽  
Cancer Cell Lines ◽  
Human Lung Cancer ◽  
Luciferase Reporter ◽  
Soluble Form ◽  
Multiple Cancer ◽  
P53 Target Gene

ABSTRACT We identified a novel mouse gene, mRTVP-1, as a p53 target gene using differential display PCR and extensive promoter analysis. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 (hRTVP-1) protein by two short in-frame deletions of two and nine amino acids. RTVP-1 mRNA was induced in multiple cancer cell lines by adenovirus-mediated delivery of p53 and by gamma irradiation or doxorubicin both in the presence and in the absence of endogenous p53. Analysis of RTVP-1 expression in nontransformed and transformed cells further supported p53-independent gene regulation. Using luciferase reporter and electrophoretic mobility shift assays we identified a p53 binding site within intron 1 of the mRTVP-1 gene. Overexpression of mRTVP-1 or hRTVP-1 induced apoptosis in multiple cancer cell lines including prostate cancer cell lines 148-1PA, 178-2BMA, PC-3, TSU-Pr1, and LNCaP, a human lung cancer cell line, H1299, and two isogenic human colon cancer cell lines, HCT116 p53+/+ and HCT116 p53−/−, as demonstrated by annexin V positivity, phase-contrast microscopy, and in selected cases 4′,6′-diamidino-2-phenylindole staining and DNA fragmentation. Deletion of the signal peptide from the N terminus of RTVP-1 reduced its apoptotic activities, suggesting that a secreted and soluble form of RTVP-1 may mediate, in part, its proapoptotic activities.

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines
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