scholarly journals Treatment satisfaction with insulin glargine in patients with diabetes mellitus in a university hospital clinic in Sweden

2009 ◽  
Vol 6 (1) ◽  
pp. 17-22 ◽  
Author(s):  
M Annersten Gershater ◽  
A Frid ◽  
J Apelqvist
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Glargine ◽  
Treatment Satisfaction ◽  
University Hospital ◽  
Patients With Diabetes ◽  
Hospital Clinic

scholarly journals Switching from biosimilar (Basalin) to originator (Lantus) insulin glargine is effective in Chinese patients with diabetes mellitus: a retrospective chart review

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 477 ◽  
Author(s):  
Xia Hu ◽  
Lei Zhang ◽  
Yanhu Dong ◽  
Chao Dong ◽  
Jikang Jiang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Insulin Glargine ◽  
Hospital Discharge ◽  
Chart Review ◽  
Insulin Dose ◽  
Retrospective Chart Review ◽  
Chinese Patients ◽  
Time Points ◽  
Patients With Diabetes

Background: This study investigated the effectiveness and safety of switching from Basalin® to Lantus® in Chinese patients with diabetes mellitus (DM). Methods:  A retrospective chart review conducted using the electronic medical records of patients hospitalized at the Qingdao Endocrine and Diabetes Hospital from 2005 to 2016. All patients were diagnosed with DM and underwent switching of insulin from Basalin to Lantus during hospitalization. Data collected included fasting (FBG), pre- and post-prandial whole blood glucose, insulin dose, reasons for insulin switching and hypoglycemia. Four study time points were defined as: hospital admission, Basalin initiation, insulin switching (date of final dose of Basalin), and hospital discharge. Blood glucose measurements were imputed as the values recorded closest to the dates of these four time points for each patient. Results: Data from 73 patients (70 patients with type 2 diabetes, 2 with type 1, and 1 undisclosed) were analyzed. At admission, mean glycated hemoglobin (HbA1c) and FBG were 8.9% (SD=1.75) and 9.98 (3.22) mmol/L, respectively. Between Basalin initiation and insulin switch, mean FBG decreased from 9.68 mmol/L to 8.03 mmol/L (p<0.0001), over a mean 10.8 (SD=6.85) days of Basalin treatment, and reduced further to 7.30 mmol/L at discharge (p=0.0116) following a mean 6.6 (7.36) days of Lantus. The final doses of Basalin and Lantus were similar (0.23 vs. 0.24 IU/kg/day; p=0.2409). Furthermore, reductions in pre- and post-prandial blood glucose were also observed between Basalin initiation, insulin switch and hospital discharge. The incidence of confirmed hypoglycemia was low during Basalin (2 [2.4%]) and Lantus (1 [1.2%]) treatment, with no cases of severe hypoglycemia. Conclusion: In this study population, switching from Basalin to Lantus was associated with further reductions in blood glucose, although the dose of insulin glargine did not increase. Further studies are required to verify these findings and determine the reason for this phenomenon.

scholarly journals The Prevalence of Nondiabetic Renal Diseases in Patients with Diabetes Mellitus in the University Hospital of Ribeirão Preto, São Paulo

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Diego Agra Souza ◽  
Gyl Eanes Barros Silva ◽  
Igor Lima Fernandes ◽  
Dyego José Araújo de Brito ◽  
Monique Pereira Rêgo Muniz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Membranous Glomerulonephritis ◽  
Sao Paulo ◽  
Group Iv ◽  
University Hospital ◽  
Renal Diseases ◽  
Group I ◽  
Patients With Diabetes ◽  
The University ◽  
Time Since Diagnosis

Objective. To evaluate the prevalence of nondiabetic renal diseases (NDRDs) in renal biopsies of patients with diabetes mellitus (DM) in the University Hospital of Ribeirão Preto, São Paulo. Research Design and Methods. We conducted a retrospective study including kidney biopsies performed in diabetic patients between 1987 and 2013. We evaluated 79 biopsies during this period. The primary variable was the prevalence of NDRD in patients with DM. The secondary variables were the presence of systemic arterial hypertension (SAH), hematuria, time since diagnosis of DM, serum creatinine, and proteinuria levels. The cases were divided into the following groups: isolated diabetic nephropathy (DN—group I), isolated nondiabetic renal diseases (NDRD—group II), associated NDRD/DN (group III), and associated NDRD+NDRD/DN (group IV). Results. Most of the patients (58.22%) presented only alterations arising from DN. NDRDs were present in 41.77% of the patients. Membranous glomerulonephritis (30.3%) and IgA nephropathy (24.24%) were the most prevalent NDRDs. We found no differences between female and male patients with NDRD when assessing the secondary variables. A time since diagnosis of five years or less revealed a statistical difference (p=0.0005) in the comparison between the isolated DN (group I) and the NDRD+NDRD/DN (group IV). The other secondary variables were not significant in the comparison of the groups. Conclusions. We concluded that the prevalence of NDRD is 41.77%. Membranous glomerulonephritis was the most prevalent NDRD in our study. We also conclude that the probability of the presence of NDRD with or without concomitant DN is greater for patients who had biopsies with a time since diagnosis of five years or less. A time since diagnosis of ten years or more does not allow the exclusion of the presence of NDRD.

scholarly journals Demanda de pacientes com diabetes mellitus em unidade de urgência de um Hospital Universitário/ Profile of patients with diabetes mellitus in the emergency unit of a University Hospital

2016 ◽  
Vol 15 (2) ◽  
pp. 312 ◽  
Author(s):  
Tatiane Aparecida Martins ◽  
Claudia Benedita Dos Santos ◽  
Manoel Antônio dos Santos ◽  
Flávia Fernanda Luchetti Rodrigues ◽  
Cesar Eduardo Pedersoli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
University Hospital ◽  
Emergency Unit ◽  
Patients With Diabetes

Este é um estudo transversal, cujo objetivo foi identificar o perfil de pacientes com diabetes mellitus em Unidade de Urgência. A amostra probabilística foi constituída por 247 pacientes de um hospital do interior paulista, Brasil, em 2009. Um formulário estruturado, contendo variáveis sociodemográficas, clínicas e relacionadas às orientações de enfermagem, oferecidas na alta hospitalar, foi utilizado para obtenção dos dados nos prontuários de saúde. Para análise dos dados, foi utilizada estatística descritiva. Os resultados mostraram que os pacientes admitidos eram predominantemente do gênero feminino (53,4%), brancos (79,8%), com baixa escolaridade (76,6%) e idade entre 58 e 77 anos (50,2%); média de 62 anos e desvio-padrão de 15,3 anos. Quanto à procura pelo atendimento, os diagnósticos mais prevalentes foram: problemas cardiovasculares (22,3%) e cerebrovasculares (13%). O diabetes foi considerado motivo secundário para admissão no serviço, o primário foi relacionado apenas à queixa principal do paciente. O tempo de internação foi, em média, de quatro dias, com mediana de nove dias e desvio-padrão de 21,7. As orientações de enfermagem registradas em prontuário na alta hospitalar se restringiram aos retornos ambulatoriais. Há necessidade de melhor articulação da rede de atenção primária e hospitalar para redução da demanda evitável de pacientes com diabetes em unidade de urgência.

scholarly journals The Insulin Treatment Satisfaction Questionnaire and Assessment of Satisfaction with a Latest-generation Insulin Pump

2015 ◽  
Vol 11 (2) ◽  
pp. 67
Author(s):  
Michael Bromba ◽  
Fiona Campbell ◽  
Brian L Levy ◽  
◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Quality Of Care ◽  
Treatment Satisfaction ◽  
Insulin Treatment ◽  
Insulin Pump ◽  
Previous Treatment ◽  
Improve Quality ◽  
Satisfaction Questionnaire ◽  
Patients With Diabetes

Satisfaction with the latest-generation insulin pump (LGIP) was assessed in patients with diabetes mellitus enrolled in the Comparing Perception of Insulin Therapies for T1D Patients with the Aim to Improve Quality of Care (CHOICE) study. The Insulin Treatment Satisfaction Questionnaire (ITSQ), a measure of insulin treatment satisfaction, together with additional questions assessed respondents’ perceptions of glucose control, their satisfaction with major LGIP features and preference for the LGIP versus their previous treatment, was used. The LGIP (Animas® Vibe™) was considered to be a better method for delivering insulin compared with their therapy before switching and was rated high for treatment satisfaction. These findings should be useful to clinicians when considering the possibility of transferring a patient from their existing treatment regimen to a LGIP.

scholarly journals Association Between Cortisol and Left Ventricular Diastolic Dysfunction in Patients With Diabetes Mellitus: A Case Control Study

2021 ◽  
Author(s):  
RIKAKO SAGARA ◽  
Tomoaki Inoue ◽  
Noriyuki Sonoda ◽  
Chieko Yano ◽  
Misato Motoya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Linear Regression Analysis ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
University Hospital ◽  
Multivariate Linear Regression Analysis ◽  
Diastolic Velocity ◽  
Ventricular Diastolic Dysfunction ◽  
Patients With Diabetes

Abstract Introduction: Diabetes mellitus (DM) is a major risk factor for the development of cardiovascular diseases. Heart failure with preserved ejection fraction is characterized by left ventricular diastolic dysfunction (LVDD). It has been reported that excess cortisol found in patients with Cushing’s syndrome was associated with the development of LVDD. However, the relationship between cortisol concentration and LVDD in patients with DM has not been addressed. Research Design and Methods: We enrolled 109 patients with DM and 104 patients without DM who had undergone echocardiographic examination at Kyushu University Hospital, Japan, between November 2016 and March 2019. Left ventricular function was evaluated and the ratio of early diastolic velocity from transmitral inflow to early diastolic velocity (E/eʹ) was used as an index of diastolic function. Plasma cortisol concentrations, glycemic control, lipid profiles, treatment with anti-diabetic drugs, and other clinical characteristics were evaluated, and their associations with E/eʹ were determined using univariate and multivariate analyses. Results Multivariate linear regression analysis showed that log E/eʹ was positively correlated with age (p = 0.017), log systolic blood pressure (p = 0.004), and cortisol (p = 0.037) and negatively correlated with eGFR (p = 0.016) and the usage of SGLT2 inhibitors (p = 0.042) in patients with DM. Multivariate analysis showed that cortisol was positively correlated with age (p = 0.016) and HbA1c (p = 0.011). There was no association between E/eʹ and cortisol in patients without DM. Conclusions Increased cortisol levels may increase the risk of developing LVDD in DM patients.

scholarly journals Prevalence of Skin Manifestations in Diabetes Mellitus at King Abdulaziz University Hospital

2012 ◽  
Vol 2 (1) ◽  
pp. 19-22
Author(s):  
Sameer KH. Zimmo
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
University Hospital ◽  
Skin Manifestations ◽  
High Prevalence ◽  
Patients With Diabetes ◽  
Common Skin ◽  
King Abdulaziz University ◽  
Diabetic Population ◽  
The Common

Background: The prevalence of diabetes in Saudi Arabia is now one of the highest in the world, with the rise in prevalence of Type II diabetes. Patients with diabetes mellitus commonly suffer from a wide variety of cutaneous disorders. Aims: This study estimates the prevalence of skin manifestations in patients with diabetes mellitus, at King Abdulaziz University Hospital. Materials and Methods: Five hundred and fifty-eight patients with the diagnosis of diabetes, attending the dermatologic and diabetic clinic were included in this study. Results: The common skin disorders were: xerosis (74.7%), pruritus (38.2%), diabetic dermopathy (30.1%), finger pebbles (25.6%), and thickened skin (22.2%). Conclusion: Skin manifestations in diabetics are common. High prevalence of xerosis in our diabetic population is significant and further studies are recommended.

scholarly journals Effectiveness of Insulin Degludec in Thai Patients with Diabetes Mellitus: Real-World Evidence From a Specialized Diabetes Center

2019 ◽  
Author(s):  
Yotsapon Thewjitcharoen ◽  
Nalin Yenseung ◽  
Areeya Malidaeng ◽  
Siriwan Butadej ◽  
Phawinpon Chotwanvirat ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Patient Satisfaction ◽  
Glycemic Control ◽  
Insulin Glargine ◽  
Real World ◽  
Insulin Degludec ◽  
Minimal Weight ◽  
Acting Insulin ◽  
Patients With Diabetes ◽  
Long Acting

Abstract Background Insulin degludec, an ultra-long-acting insulin analogue, has been available in Thailand since October 2016. Although clinical trial results revealed less hypoglycemia, data from real-world settings is limited especially in Asian patients. This study aimed to evaluate prospectively the real-world effectiveness, safety, quality of life (QOL) and patient satisfaction with insulin degludec among Thai patients with diabetes mellitus (DM). Methods From October 2016 to September 2017, all patients who had started insulin degludec for at least 3 months were observed and evaluated at baseline, 3, 6, and 12 months. QOL was assessed using WHOQOL-BREF-THAI and level of satisfaction was measured by 7-point Likert scale. Glycemic fluctuation from paired iPro2 continuous glucose monitoring (CGM) obtained 4–6 weeks apart were also evaluated from a subset of patients with T1DM who switched from insulin glargine to insulin degludec. Results A total of 55 patients (T2DM 76.4%, females 54.5%, mean age 57.1±16.1 years, duration of diabetes 16.7±8.8 years, BMI 27.3±5.5 kg/m2, baseline A1C 9.3±2.3%, median duration of treatment 8 months) were included in the study. In T1DM patients (n=13), the overall mean A1C reduction at 12 months was 0.5% with minimal weight gain of 0.9 kgs at 12 months. In T2DM patients (n=42), the overall mean A1C reduction at 12 months was 0.8% with minimal weight loss of 0.4 kgs at 12 months. The proportion of T1DM patients who could achieve optimal glycemic control increased slightly from 14.3 to 18.2% but the proportion of T2DM patients who could achieve optimal glycemic control increased from 30.8 to 53.8%. Patient satisfaction showed a sustained improvement throughout the duration of study. In four T1DM patients who had paired CGM data, insulin degludec provided greater reductions in glycemic variability endpoints with increased time-in-range when compared with previous insulin glargine. Discussion Our data suggested that the effectiveness of insulin degludec was consistent with the results seen in clinical trials with lower risk of patients-reported hypoglycemia, and a significant improvement in glycemic control. Patients also reported higher treatment satisfaction. More long-term and cost-effectiveness data are needed to establish the role of this ultra-long-acting insulin in real-world settings.

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