scholarly journals Reduced maternal vitamin A status increases the incidence of normal aortic arch variants

genesis ◽  
2019 ◽  
Vol 57 (11-12) ◽  
Author(s):  
Kelsey F. Sugrue ◽  
Irene E. Zohn
Keyword(s):  
Vitamin A ◽  
Aortic Arch ◽  
Maternal Vitamin ◽  
Vitamin A Status

scholarly journals Impact of Maternal Daily Oral Low-Dose Vitamin A Supplementation on the Mother–Infant Pair: A Randomised Placebo-Controlled Trial in China

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2370
Author(s):  
Ye Ding ◽  
Ping Hu ◽  
Yue Yang ◽  
Fangping Xu ◽  
Fang Li ◽  
...  
Keyword(s):  
Health Status ◽  
Breast Milk ◽  
Vitamin A ◽  
Low Dose ◽  
Maternal Serum ◽  
Control Group ◽  
Vitamin A Supplementation ◽  
Maternal Vitamin ◽  
Vitamin A Status ◽  
Lactating Mothers

Background: The nutritional status of vitamin A in lactating mothers and infants is still not optimistic. Due to the dietary habits and dietary restrictions of postpartum customs in China, vitamin A supplementation has been advocated as a potential strategy to improve vitamin A status of lactating mothers with inadequate dietary vitamin A intake. Existing clinical trials are limited to single or double high-dose maternal administrations. However, in China, vitamin A supplements are readily available in the form of daily oral low-dose supplements, and the effect of these is unknown. This study aimed to evaluate the effects of daily oral low-dose vitamin A supplementation on the retinol levels in the serum and breast milk of lactating mothers and the health status of infants in China. Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breastfeeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800 IU vitamin A and 600 IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. During the trial, the health status of infants was diagnosed by a paediatrician or reported by lactating mothers. A total of 245 participants completed the study, with 117 in the supplementation group and 128 in the control group. Results: After the 2-month intervention, maternal serum retinol concentrations increased in the supplementation group with no change in the control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in the supplementation group was significantly lower than that in the control group. However, maternal vitamin A supplementation was not associated with a lower risk of infant febrile illness, respiratory tract infection, diarrhoea, and eczema. Conclusions: Daily oral low-dose vitamin A supplementation is helpful in improving maternal vitamin A status, despite having no effect on infant health status through breast milk.

Effect of Subadequate Maternal Vitamin-A Status on Placental Transfer of Retinol and Beta-Carotene to the Human Fetus

Neonatology ◽  
1996 ◽  
Vol 69 (4) ◽  
pp. 230-234 ◽  
Author(s):  
R. Dimenstein ◽  
N.M.F. Trugo ◽  
C.M. Donangelo ◽  
L.C. Trugo ◽  
A.S. Anastácio
Keyword(s):  
Vitamin A ◽  
Human Fetus ◽  
Placental Transfer ◽  
Beta Carotene ◽  
Maternal Vitamin ◽  
Vitamin A Status

Use of Red Palm Oil for the Promotion of Maternal Vitamin A Status

2000 ◽  
Vol 21 (2) ◽  
pp. 215-218 ◽  
Author(s):  
G. Lietz ◽  
C. J. K. Henry ◽  
G. Mulokozi ◽  
J. Mugyabuso ◽  
A. Ballart ◽  
...  
Keyword(s):  
Vitamin A ◽  
Palm Oil ◽  
Maternal Vitamin ◽  
Red Palm Oil ◽  
Vitamin A Status

scholarly journals Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice

2021 ◽  
Author(s):  
Ayanna W. Rocke ◽  
Tianna G. Clarke ◽  
Timothy R. A. Dalmer ◽  
Sydney A. McCluskey ◽  
Juan F. Garcia Rivas ◽  
...  
Keyword(s):  
Risk Factor ◽  
Vitamin A ◽  
Mouse Model ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Epidemiological Data ◽  
Dietary Vitamin ◽  
Maternal Vitamin ◽  
Retinoid Signaling ◽  
Vitamin A Status

Abstract Background Congenital diaphragmatic hernia (CDH) is a severe birth defect associated with high perinatal mortality and long-term morbidity. The etiology of CDH is poorly understood although abnormal retinoid signaling has been proposed to contribute to abnormal diaphragm development. Existing epidemiological data suggest that inadequate dietary vitamin A intake is a risk factor for developing CDH. Methods Using a mouse model of teratogen-induced CDH, the objective of this study was to test the hypothesis that low maternal vitamin A intake contributes to abnormal diaphragm development. To test this hypothesis, we optimized a model of altered maternal dietary vitamin A intake and a teratogenic model of CDH in mice that recapitulates the hallmark features of posterolateral diaphragmatic hernia in humans. Results Our data uniquely show that low maternal dietary vitamin A intake and marginal vitamin A status increases the incidence of teratogen-induced CDH in mice. Conclusion Low dietary vitamin A intake and marginal vitamin A status lead to an increased incidence of teratogen-induced CDH in mice, highlighting the importance of adequate dietary vitamin A intake and CDH risk. Impact This study describes and validates a mouse model of altered maternal and fetal vitamin A status. This study links existing epidemiological data with a mouse model of teratogen-induced congenital diaphragmatic hernia, highlighting the importance of low maternal vitamin A intake as a risk factor for the development of congenital diaphragmatic hernia. This study supports the Retinoid Hypothesis, which posits that the etiology of congenital diaphragmatic hernia is linked to abnormal retinoid signaling in the developing diaphragm.

scholarly journals Maternal vitamin A status and mother-to-child transmission of HIV in West Africa

AIDS ◽  
2000 ◽  
Vol 14 (7) ◽  
pp. 908
Author(s):  
Katia Castetbon ◽  
Olivier Manigart ◽  
Dominique Bonard ◽  
Marie-Josée Thomas ◽  
Marie-France Dumon ◽  
...  
Keyword(s):  
Vitamin A ◽  
West Africa ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Maternal Vitamin ◽  
Vitamin A Status ◽  
Mother To Child
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