The effects of marginal maternal vitamin A status on penta-brominated diphenyl ether mixture-induced alterations in maternal and conceptal vitamin A and fetal development in the Sprague Dawley rat

2009 ◽  
Vol 86 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Robert G. Ellis-Hutchings ◽  
Gary N. Cherr ◽  
Lynn A. Hanna ◽  
Carl L. Keen
Keyword(s):  
Vitamin A ◽  
Fetal Development ◽  
Diphenyl Ether ◽  
Sprague Dawley ◽  
Maternal Vitamin ◽  
Sprague Dawley Rat ◽  
Vitamin A Status ◽  
Ether Mixture

scholarly journals Impact of Maternal Daily Oral Low-Dose Vitamin A Supplementation on the Mother–Infant Pair: A Randomised Placebo-Controlled Trial in China

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2370
Author(s):  
Ye Ding ◽  
Ping Hu ◽  
Yue Yang ◽  
Fangping Xu ◽  
Fang Li ◽  
...  
Keyword(s):  
Health Status ◽  
Breast Milk ◽  
Vitamin A ◽  
Low Dose ◽  
Maternal Serum ◽  
Control Group ◽  
Vitamin A Supplementation ◽  
Maternal Vitamin ◽  
Vitamin A Status ◽  
Lactating Mothers

Background: The nutritional status of vitamin A in lactating mothers and infants is still not optimistic. Due to the dietary habits and dietary restrictions of postpartum customs in China, vitamin A supplementation has been advocated as a potential strategy to improve vitamin A status of lactating mothers with inadequate dietary vitamin A intake. Existing clinical trials are limited to single or double high-dose maternal administrations. However, in China, vitamin A supplements are readily available in the form of daily oral low-dose supplements, and the effect of these is unknown. This study aimed to evaluate the effects of daily oral low-dose vitamin A supplementation on the retinol levels in the serum and breast milk of lactating mothers and the health status of infants in China. Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breastfeeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800 IU vitamin A and 600 IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. During the trial, the health status of infants was diagnosed by a paediatrician or reported by lactating mothers. A total of 245 participants completed the study, with 117 in the supplementation group and 128 in the control group. Results: After the 2-month intervention, maternal serum retinol concentrations increased in the supplementation group with no change in the control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in the supplementation group was significantly lower than that in the control group. However, maternal vitamin A supplementation was not associated with a lower risk of infant febrile illness, respiratory tract infection, diarrhoea, and eczema. Conclusions: Daily oral low-dose vitamin A supplementation is helpful in improving maternal vitamin A status, despite having no effect on infant health status through breast milk.

Effect of Subadequate Maternal Vitamin-A Status on Placental Transfer of Retinol and Beta-Carotene to the Human Fetus

Neonatology ◽  
1996 ◽  
Vol 69 (4) ◽  
pp. 230-234 ◽  
Author(s):  
R. Dimenstein ◽  
N.M.F. Trugo ◽  
C.M. Donangelo ◽  
L.C. Trugo ◽  
A.S. Anastácio
Keyword(s):  
Vitamin A ◽  
Human Fetus ◽  
Placental Transfer ◽  
Beta Carotene ◽  
Maternal Vitamin ◽  
Vitamin A Status

scholarly journals Vitamin A Status and Deposition in Neonatal and Weanling Rats Reared by Mothers Consuming Normal and High-Fat Diets with Adequate or Supplemented Vitamin A

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1460 ◽  
Author(s):  
Yanqi Zhang ◽  
Kristi M. Crowe-White ◽  
Lingyan Kong ◽  
Libo Tan
Keyword(s):  
Adipose Tissue ◽  
Vitamin A ◽  
Maternal Obesity ◽  
Sprague Dawley ◽  
High Fat ◽  
Vitamin A Status ◽  
Brown Adipose ◽  
Weanling Rats ◽  
Storage Organs ◽  
Fat Diets

The circulating level of vitamin A (VA; retinol) was reported to be lower in obese adults. It is unknown if maternal obesity influences the VA status of offspring. The objective of the study was to determine the VA status and deposition of neonatal and weanling rats reared by mothers consuming a normal or high-fat diet (NFD or HFD) with or without supplemented VA. Pregnant Sprague-Dawley rats were randomized to an NFD or HFD with 2.6 mg/kg VA. Upon delivery, half of the rat mothers in the NFD or HFD cohort were switched to an NFD or HFD with supplemented VA at 129 mg/kg (NFD+VA and HFD+VA group). The other half remained on their original diet (NFD and HFD group). At postnatal day 14 (P14), P25, and P35, pups (n = 4 or 3/group/time) were euthanized. The total retinol concentration in the serum, liver, visceral white adipose tissue (WAT), and brown adipose tissue (BAT) was measured. At P14, the HFD+VA group showed a significantly lower serum VA than the NFD+VA group. At P25, both the VA concentration and total mass in the liver, WAT, and BAT were significantly higher in the HFD+VA than the NFD+VA group. At P35, the HFD group exhibited a significantly higher VA concentration and mass in the liver and BAT compared with the NFD group. In conclusion, maternal HFD consumption resulted in more VA accumulation in storage organs in neonatal and/or weanling rats, which potentially compromised the availability of VA in circulation, especially under the VA-supplemented condition.

Toxicologic and immunologic effects of perinatal exposure to the brominated diphenyl ether (BDE) mixture DE-71 in the Sprague-Dawley rat

2011 ◽  
Vol 28 (4) ◽  
pp. 215-228 ◽  
Author(s):  
Genevieve S. Bondy ◽  
David E. Lefebvre ◽  
Syed Aziz ◽  
Wendy Cherry ◽  
Laurie Coady ◽  
...  
Keyword(s):  
Diphenyl Ether ◽  
Perinatal Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rat
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