scholarly journals Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives

2010 ◽  
Vol 239 (11) ◽  
pp. 3086-3097 ◽  
Author(s):  
Ralston M. Barnes ◽  
Beth A. Firulli ◽  
Simon J. Conway ◽  
Joshua W. Vincentz ◽  
Anthony B. Firulli
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Lateral Mesoderm

Cell lineage analysis in neural crest ontogeny

1993 ◽  
Vol 24 (2) ◽  
pp. 146-161 ◽  
Author(s):  
Nicole M. Le Douarin ◽  
Elisabeth Dupin
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Lineage Analysis

scholarly journals Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

Glia ◽  
2008 ◽  
Vol 56 (14) ◽  
pp. 1481-1490 ◽  
Author(s):  
Ashwin Woodhoo ◽  
Lukas Sommer
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Cell Lineage ◽  
Myelinated Nerve

Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

Development ◽  
2000 ◽  
Vol 127 (8) ◽  
pp. 1671-1679 ◽  
Author(s):  
Y. Chai ◽  
X. Jiang ◽  
Y. Ito ◽  
P. Bringas ◽  
J. Han ◽  
...  
Keyword(s):  
Neural Crest ◽  
Genetic Manipulation ◽  
Cell Lineage ◽  
Neural Crest Cell ◽  
Neural Crest Cells ◽  
Genetic System ◽  
Branchial Arch ◽  
Mouse Line ◽  
Cranial Neural Crest ◽  
Two Component

Neural crest cells are multipotential stem cells that contribute extensively to vertebrate development and give rise to various cell and tissue types. Determination of the fate of mammalian neural crest has been inhibited by the lack of appropriate markers. Here, we make use of a two-component genetic system for indelibly marking the progeny of the cranial neural crest during tooth and mandible development. In the first mouse line, Cre recombinase is expressed under the control of the Wnt1 promoter as a transgene. Significantly, Wnt1 transgene expression is limited to the migrating neural crest cells that are derived from the dorsal CNS. The second mouse line, the ROSA26 conditional reporter (R26R), serves as a substrate for the Cre-mediated recombination. Using this two-component genetic system, we have systematically followed the migration and differentiation of the cranial neural crest (CNC) cells from E9.5 to 6 weeks after birth. Our results demonstrate, for the first time, that CNC cells contribute to the formation of condensed dental mesenchyme, dental papilla, odontoblasts, dentine matrix, pulp, cementum, periodontal ligaments, chondrocytes in Meckel's cartilage, mandible, the articulating disc of temporomandibular joint and branchial arch nerve ganglia. More importantly, there is a dynamic distribution of CNC- and non-CNC-derived cells during tooth and mandibular morphogenesis. These results are a first step towards a comprehensive understanding of neural crest cell migration and differentiation during mammalian craniofacial development. Furthermore, this transgenic model also provides a new tool for cell lineage analysis and genetic manipulation of neural-crest-derived components in normal and abnormal embryogenesis.

Interactions between rhombomeres modulate Krox-20 and follistatin expression in the chick embryo hindbrain

Development ◽  
1996 ◽  
Vol 122 (2) ◽  
pp. 473-480 ◽  
Author(s):  
A. Graham ◽  
A. Lumsden
Keyword(s):  
Chick Embryo ◽  
Neural Crest ◽  
Cell Lineage ◽  
Signalling Molecule ◽  
Neighbour Interaction

The rhombomeres of the embryonic hindbrain display compartment properties, including cell lineage restriction, genetic definition and modular anatomical phenotype. Consistent with the idea that rhombomeres are autonomous developmental units, previous studies have shown that certain aspects of rhombomere phenotype are determined early, at the time of rhombomere formation. By contrast, the apoptotic depletion of neural crest from rhombomeres 3 and 5 is due to an interaction with their neighbouring rhombomeres, involving the signalling molecule Bmp4. In this paper, we have examined whether inter-rhombomere interactions control further aspects of rhombomere phenotype. We find that the expression of Krox-20 and the repression of follistatin in r3 is dependent upon neighbour interaction, whereas these genes are expressed autonomously in r5. We further demonstrate that modulation of Krox-20 and follistatin expression is not dependent on Bmp4, indicating the existence of multiple pathways of interaction between adjacent rhombomeres. We also show that, although some phenotypic aspects of r3 are controlled by neighbour interactions, the axial identity of the segment is intrinsically determined.

Cell Lineage Segregation during Neural Crest Ontogeny

1990 ◽  
Vol 599 (1 Cell Lineages) ◽  
pp. 131-140 ◽  
Author(s):  
NICOLE M. DOUARIN
Keyword(s):  
Neural Crest ◽  
Cell Lineage

The neural crest cell lineage problem: Neuropoiesis?

Neuron ◽  
1989 ◽  
Vol 3 (1) ◽  
pp. 1-12 ◽  
Author(s):  
David J. Anderson
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Neural Crest Cell ◽  
Crest Cell
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