Cell Lineage Analysis during Neural Crest Ontogeny and Early Patterning of Peripheral Ganglia

2015 ◽  
pp. 62-87
Author(s):  
Nicole M. Le Douarin
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Lineage Analysis

Cell lineage analysis in neural crest ontogeny

1993 ◽  
Vol 24 (2) ◽  
pp. 146-161 ◽  
Author(s):  
Nicole M. Le Douarin ◽  
Elisabeth Dupin
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Lineage Analysis

scholarly journals Neural crest lineage analysis: from past to future trajectory

Development ◽  
2020 ◽  
Vol 147 (20) ◽  
pp. dev193193 ◽  
Author(s):  
Weiyi Tang ◽  
Marianne E. Bronner
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Single Molecule ◽  
Cell Lineage ◽  
Neural Crest Cell ◽  
Cell Types ◽  
Lineage Tracing ◽  
Migration Routes ◽  
Developmental Potential ◽  
Lineage Analysis

ABSTRACTSince its discovery 150 years ago, the neural crest has intrigued investigators owing to its remarkable developmental potential and extensive migratory ability. Cell lineage analysis has been an essential tool for exploring neural crest cell fate and migration routes. By marking progenitor cells, one can observe their subsequent locations and the cell types into which they differentiate. Here, we review major discoveries in neural crest lineage tracing from a historical perspective. We discuss how advancing technologies have refined lineage-tracing studies, and how clonal analysis can be applied to questions regarding multipotency. We also highlight how effective progenitor cell tracing, when combined with recently developed molecular and imaging tools, such as single-cell transcriptomics, single-molecule fluorescence in situ hybridization and high-resolution imaging, can extend the scope of neural crest lineage studies beyond development to regeneration and cancer initiation.

Cell lineage analysis reveals multipotency of some avian neural crest cells

Nature ◽  
1988 ◽  
Vol 335 (6186) ◽  
pp. 161-164 ◽  
Author(s):  
Marianne Bronner-Fraser ◽  
Scott E. Fraser
Keyword(s):  
Neural Crest ◽  
Cell Lineage ◽  
Neural Crest Cells ◽  
Lineage Analysis

Major sex-determining genes and the control of sexual dimorphism in Caenorhabditis elegans

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 625-637 ◽  
Author(s):  
Jonathan Hodgkin ◽  
Andrew D. Chisholm ◽  
Michael M. Shen
Keyword(s):  
Caenorhabditis Elegans ◽  
Sex Determination ◽  
X Chromosome ◽  
Germ Line ◽  
Cell Lineage ◽  
Regulatory Genes ◽  
Nematode Caenorhabditis Elegans ◽  
X Chromosomes ◽  
The Many ◽  
Lineage Analysis

Sex determination in Caenorhabditis elegans involves a cascade of major regulatory genes connecting the primary sex determining signal, X chromosome dosage, to key switch genes, which in turn direct development along either male or female pathways. Animals with one X chromosome (XO) are male, while animals with two X chromosomes (XX) are hermaphrodite: hermaphrodite development occurs because the action of the regulatory genes is modified in the germ line so that both sperm and oocytes are made inside a completely female soma. The regulatory genes are being examined by both genetic and molecular means. We discuss how these major genes, in particular the last switch gene in the cascade, tra-1, might regulate the many different sex-specific events that occur during the development of the hermaphrodite and of the male.Key words: nematode, Caenorhabditis elegans, sex determination, sexual differentiation, cell lineage analysis.

Cell lineage of homeotic mutants of Drosophila

1985 ◽  
Vol 312 (1153) ◽  
pp. 139-144 ◽  
Keyword(s):  
Mode Of Action ◽  
Cell Lineage ◽  
Precursor Cells ◽  
Larval Period ◽  
Homeotic Genes ◽  
Lineage Analysis

The homeotic genes specify the development of specific groups of precursor cells. They establish the correct state of determination of the different primordia. Cell lineage analysis has been particularly useful in studying the mode of action of homeotic genes. The main findings are: (i) most, perhaps all, the homeotic genes are required by every cell of the corresponding primordium (that is, they are cell autonomous); (ii) they act on anatomical units defined by compartment boundaries and including one or more compartments, (iii) most, but not all, homeotic genes are required until the end of the larval period; (iv) the homeotic genes act in combination so that the appropriate development of a given primordium may be established by the contribution of several homeotic genes.

Genetic analysis of leaf development in cotton

Development ◽  
1991 ◽  
Vol 113 (Supplement_1) ◽  
pp. 39-46 ◽  
Author(s):  
Liam Dolan ◽  
R. Scott Poethig
Keyword(s):  
Leaf Growth ◽  
Leaf Shape ◽  
Cell Lineage ◽  
Cotton Leaf ◽  
Expansion Phase ◽  
Genetic Mosaics ◽  
Developmental Age ◽  
Allometric Analysis ◽  
Marginal Region ◽  
Lineage Analysis

Leaf shape in cotton is regulated by the developmental age of the shoot and by several major genes that affect leaf lobing. The effect of these factors was investigated by allometric analysis, cell lineage analysis, and by studying the expression of the leaf shape mutation, Okra, in genetic mosaics. Allometric analysis of leaf growth suggests that leaf shape is determined during the initiation of the primordium rather than during the expansion phase of leaf growth. Clonal analysis demonstrates that both the rate and duration of cell division are fairly uniform throughout the leaf. Cells in the marginal region of the developing cotton leaf contribute more to the growth of the lamina than they do in tobacco. The Okra mutation acts early in the development of a leaf and appears to accentuate a developmental pattern that is also responsible for heteroblastic variation in leaf shape. The expression of this mutation in genetic mosaics demonstrates that its effect does not diffuse laterally within the leaf primordium.

Cell lineage analysis of Schwann cells in the PNS determined by shiverer-normal mouse chimeras

1984 ◽  
Vol 105 (1) ◽  
pp. 221-226 ◽  
Author(s):  
Katsuhiko Mikoshiba ◽  
Minesuke Yokoyama ◽  
Ken Takamatsu ◽  
Yasuzo Tsukada ◽  
Tatsuji Nomura
Keyword(s):  
Schwann Cells ◽  
Normal Mouse ◽  
Cell Lineage ◽  
Mouse Chimeras ◽  
Lineage Analysis

scholarly journals Establishment of signaling interactions with cellular resolution for every cell cycle of embryogenesis

2018 ◽  
Author(s):  
Long Chen ◽  
Vincy Wing Sze Ho ◽  
Ming-Kin Wong ◽  
Xiaotai Huang ◽  
Lu-yan Chan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Notch Signaling ◽  
Cell Lineage ◽  
Cellular Interaction ◽  
Cell Contact ◽  
Contact Map ◽  
C Elegans ◽  
Cellular Resolution ◽  
Signaling Interactions ◽  
Lineage Analysis

AbstractIntercellular signaling interaction plays a key role in breaking fate symmetry during animal development. Identification of the signaling interaction at cellular resolution is technically challenging, especially in a developing embryo. Here we develop a platform that allows automated inference and validation of signaling interaction for every cell cycle of C. elegans embryogenesis. This is achieved by generation of a systems-level cell contact map that consists of 1,114 highly confident intercellular contacts by modeling analysis and is validated through cell membrane labeling coupled with cell lineage analysis. We apply the map to identify cell pairs between which a Notch signaling interaction takes place. By generating expression patterns for two ligands and two receptors of Notch signaling pathway with cellular resolution using automated expression profiling technique, we are able to refine existing and identify novel Notch interactions during C. elegans embryogenesis. Targeted cell ablation followed by cell lineage analysis demonstrates the roles of signaling interactions over cell division in breaking fate symmetry. We finally develop a website that allows online access to the cell-cell contact map for mapping of other signaling interaction in the community. The platform can be adapted to establish cellular interaction from any other signaling pathways.

scholarly journals Development of the Schwann cell lineage: From the neural crest to the myelinated nerve

Glia ◽  
2008 ◽  
Vol 56 (14) ◽  
pp. 1481-1490 ◽  
Author(s):  
Ashwin Woodhoo ◽  
Lukas Sommer
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Cell Lineage ◽  
Myelinated Nerve
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