scholarly journals Neonatal overexpression of estrogen receptor-α alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring

2014 ◽  
Vol 75 (10) ◽  
pp. 1114-1124 ◽  
Author(s):  
Catherine Jensen Peña ◽  
Frances A. Champagne
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Estrogen Receptor Α ◽  
Female Offspring ◽  
Dopamine Neuron ◽  
Neuron Development ◽  
Midbrain Dopamine

scholarly journals Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2909-2915 ◽  
Author(s):  
Frances A. Champagne ◽  
Ian C. G. Weaver ◽  
Josie Diorio ◽  
Sergiy Dymov ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Female Offspring ◽  
Medial Preoptic Area

Molecular mechanisms underlying midbrain dopamine neuron development and function

2003 ◽  
Vol 480 (1-3) ◽  
pp. 75-88 ◽  
Author(s):  
Marten P. Smidt ◽  
Simone M. Smits ◽  
J.Peter H. Burbach
Keyword(s):  
Molecular Mechanisms ◽  
Dopamine Neuron ◽  
Neuron Development ◽  
Midbrain Dopamine ◽  
And Function

scholarly journals SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells

Stem Cells ◽  
2012 ◽  
Vol 30 (5) ◽  
pp. 865-875 ◽  
Author(s):  
Julianna Kele ◽  
Emma R. Andersson ◽  
J. Carlos Villaescusa ◽  
Lukas Cajanek ◽  
Clare L. Parish ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Dopamine Neuron ◽  
Neuron Development ◽  
Midbrain Dopamine

scholarly journals Genetic dissection of midbrain dopamine neuron development in vivo

2012 ◽  
Vol 372 (2) ◽  
pp. 249-262 ◽  
Author(s):  
Debra Ellisor ◽  
Caroline Rieser ◽  
Bettina Voelcker ◽  
Jason T. Machan ◽  
Mark Zervas
Keyword(s):  
Dopamine Neuron ◽  
Genetic Dissection ◽  
Neuron Development ◽  
Midbrain Dopamine

Developmental Vitamin D Deficiency (DVD) and Brain Dopamine Ontogeny

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
D. Eyles ◽  
X. Cui ◽  
M. Pelekanos ◽  
J. Kesby ◽  
T. Burne ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Neuroblastoma Cell ◽  
Female Offspring ◽  
Cell Number ◽  
Neuroblastoma Cell Line ◽  
Dopamine Neuron ◽  
Metabolic Enzyme ◽  
Neuron Development ◽  
Methyl Transferase

Our group has pioneered research indicating that Developmental vitamin D (DVD) deficiency (a candidate risk factor for schizophrenia) alters both brain development and function. We have convergent evidence indicating a disturbance in dopamine signalling in this model. 1stly the superior colliculus (the proto-basal ganglia) is the initial site where the vitamin D receptor is expressed in foetal brain; 2ndly we show a reduction in Catechol-O-methyl transferase (a major metabolic enzyme for dopamine) in these foetal brains; 3rdly dopamine metabolites in the DVD deplete neonatal brain reflect this enzymatic change. When we allow these animals to mature under vitamin D normal conditions we repeatedly observe alterations in both spontaneous and psychomimetic enhanced locomotion. Consistent with the theme of persistent changes in dopamine signalling in this model we now present new data showing that dopamine transporter density and/or affinity are altered in DVD deplete female offspring whilst DA 1 receptor density and dopamine cell number are reduced in DVD deplete male offspring (all P< 0.05 n>8).Our most recent studies indicate that Nurr-1, a nuclear transcription regulator important in both bone and dopamine neuron development and survival may be a molecular mediator of these processes. Nurr-1 is upregulated by parathyroid hormone (PTH). PTH levels are 2-3 fold greater in vitamin D deficient Dams across gestation. Most importantly we have just shown that Nurr-1 is dose-dependently upregulated by parathyroid hormone (PTH) in a neuroblastoma cell line.Conclusions:Our findings strongly suggest that vitamin D directly (or indirectly via PTH) mediates dopamine neuron development.

Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring

2014 ◽  
Vol 39 (6) ◽  
pp. 946-956 ◽  
Author(s):  
Catherine Jensen Peña ◽  
Yael D. Neugut ◽  
Cali A. Calarco ◽  
Frances A. Champagne
Keyword(s):  
Maternal Care ◽  
Female Offspring ◽  
Midbrain Dopamine

scholarly journals Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development

Development ◽  
2013 ◽  
Vol 140 (6) ◽  
pp. 1342-1352 ◽  
Author(s):  
J. Yang ◽  
A. Brown ◽  
D. Ellisor ◽  
E. Paul ◽  
N. Hagan ◽  
...  
Keyword(s):  
Dopamine Neuron ◽  
Neuron Development ◽  
Midbrain Dopamine

scholarly journals Natural Variations in Maternal Care Are Associated with Estrogen Receptor α Expression and Estrogen Sensitivity in the Medial Preoptic Area

Endocrinology ◽  
2003 ◽  
Vol 144 (11) ◽  
pp. 4720-4724 ◽  
Author(s):  
Frances A. Champagne ◽  
Ian C. G. Weaver ◽  
Josie Diorio ◽  
Shakti Sharma ◽  
Michael J. Meaney
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Medial Preoptic Area ◽  
Estrogen Sensitivity ◽  
Natural Variations
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