scholarly journals Natural Variations in Maternal Care Are Associated with Estrogen Receptor α Expression and Estrogen Sensitivity in the Medial Preoptic Area

Endocrinology ◽  
2003 ◽  
Vol 144 (11) ◽  
pp. 4720-4724 ◽  
Author(s):  
Frances A. Champagne ◽  
Ian C. G. Weaver ◽  
Josie Diorio ◽  
Shakti Sharma ◽  
Michael J. Meaney
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Medial Preoptic Area ◽  
Estrogen Sensitivity ◽  
Natural Variations

scholarly journals Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2909-2915 ◽  
Author(s):  
Frances A. Champagne ◽  
Ian C. G. Weaver ◽  
Josie Diorio ◽  
Sergiy Dymov ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Female Offspring ◽  
Medial Preoptic Area

scholarly journals Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor α and β Pathways

2000 ◽  
Vol 275 (28) ◽  
pp. 21372-21379 ◽  
Author(s):  
Sumito Ogawa ◽  
Masayo Fujita ◽  
Yasunori Ishii ◽  
Hiroshi Tsurukami ◽  
Masami Hirabayashi ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Estrogen Sensitivity

scholarly journals Estrogen Receptor α Gene Promoter 0/B Usage in the Rat Sexually Dimorphic Nucleus of the Preoptic Area

Endocrinology ◽  
2010 ◽  
Vol 151 (4) ◽  
pp. 1923-1928 ◽  
Author(s):  
Tomohiro Hamada ◽  
Yasuo Sakuma
Keyword(s):  
Estrogen Receptor ◽  
Sexual Differentiation ◽  
Preoptic Area ◽  
Gene Promoter ◽  
Estrogen Receptor Α ◽  
Egfp Expression ◽  
Sexually Dimorphic ◽  
Transgenic Rats ◽  
The Core ◽  
Sexually Dimorphic Nucleus

The volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) is two to four times larger in male rats than in females; however, the mechanism for the establishment of sexual dimorphism and the function of this nucleus is almost unknown. Perinatal estrogen can cause sexual dimorphism via the estrogen receptor α (ERα). Recently, transgenic rats were generated that express enhanced green fluorescent protein (EGFP) under the control of the ERα gene promoter 0/B to tag ERα-positive neurons in the brain. In the present study, we examined whether this EGFP expression could be a marker for the SDN-POA in adults. EGFP-labeled cells were distributed in the core of the SDN-POA (0/B-SDN) of male and female transgenic rats, in accordance with the Nissl staining and immunoreactivity for the SDN marker, calbindin. They were also immunoreactive for ERα. The core was bigger in volume and contained more 0/B-SDN neurons in males than in females. The EGFP-tagged cells were packed more densely in the female core than that in males. Subcutaneous injection of 100 μg 17β-estradiol to females on the day of birth, or orchidectomy of male neonates, reversed the sexually dimorphic phenotype of the volume of the 0/B-SDN, despite not affecting the cell number. We suggest that this EGFP expression in the SDN-POA could be a useful marker to clarify the sexual differentiation and function of the SDN-POA. Moreover, the ERα gene promoter 0/B plays a key role in the organization of the sexual differentiation of the SDN-POA.

scholarly journals The Ability of Estradiol to Induce Fos Expression in a Subset of Estrogen Receptor-α-Containing Neurons in the Preoptic Area of the Ewe Depends on Reproductive Status1

Endocrinology ◽  
2000 ◽  
Vol 141 (1) ◽  
pp. 190-196 ◽  
Author(s):  
Ivan Stefanovic ◽  
Brian Adrian ◽  
Heiko T. Jansen ◽  
Michael N. Lehman ◽  
Robert L. Goodman
Keyword(s):  
Estrogen Receptor ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Fos Expression
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