Effects of maternal care on the development of midbrain dopamine pathways and reward-directed behavior in female offspring

2014 ◽  
Vol 39 (6) ◽  
pp. 946-956 ◽  
Author(s):  
Catherine Jensen Peña ◽  
Yael D. Neugut ◽  
Cali A. Calarco ◽  
Frances A. Champagne
Keyword(s):  
Maternal Care ◽  
Female Offspring ◽  
Midbrain Dopamine

The Hard Life Of Female Offspring When Sharing Maternal Care With A Brother

2018 ◽  
Author(s):  
Juan C. Alonso ◽  
Enrique Martín ◽  
Manuel B. Morales ◽  
Javier A. Alonso
Keyword(s):  
Maternal Care ◽  
Female Offspring

Within- and between-litter maternal care alter behavior and gene regulation in female offspring.

2014 ◽  
Vol 128 (6) ◽  
pp. 736-748 ◽  
Author(s):  
Pauline Pan ◽  
Alison S. Fleming ◽  
Daeria Lawson ◽  
Jennifer M. Jenkins ◽  
Patrick O. McGowan
Keyword(s):  
Gene Regulation ◽  
Maternal Care ◽  
Female Offspring

Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: Implications for postpartum mood disorder

2007 ◽  
Vol 32 (3) ◽  
pp. 267-278 ◽  
Author(s):  
Oliver J. Bosch ◽  
Werner Müsch ◽  
Remco Bredewold ◽  
David A. Slattery ◽  
Inga D. Neumann
Keyword(s):  
Mood Disorder ◽  
Hpa Axis ◽  
Prenatal Stress ◽  
Maternal Care ◽  
Female Offspring ◽  
Hpa Axis Activity

Effect of paracetamol treatment on maternal care and reproductive outcomes in female rat offspring

2020 ◽  
Vol 32 (18) ◽  
pp. 1311
Author(s):  
Jeberson F. Aleixo ◽  
Marina R. F. Pereira ◽  
Bruno G. Montagnini ◽  
Matheus Junior D. Pereira ◽  
Simone Forcato ◽  
...  
Keyword(s):  
Sexual Development ◽  
Maternal Care ◽  
Wistar Rats ◽  
Reproductive Behaviour ◽  
Female Offspring ◽  
Female Rat ◽  
Anogenital Distance ◽  
Rat Offspring ◽  
Grooming Behaviour ◽  
Plasma Oestradiol

Paracetamol (PAR) is one of the most commonly used drugs by pregnant women because it is considered safe for the mother and fetus. However, PAR is transferred into breast milk and crosses the blood–placental barrier, being present in the progeny during important stages of development. Intrauterine exposure to PAR may decrease the anogenital distance and follicle reserve in female rodent offspring. Therefore, the aim of the present study was to evaluate whether maternal PAR treatment altered the reproductive behaviour of dams and the sexual development of female rat offspring. Pregnant Wistar rats were gavaged daily with 350mg kg−1 day−1 PAR or water during gestation (from Gestation Day (GD) 6 until delivery) or during gestation and lactation (from GD6 until weaning). Maternal PAR treatment had maternal effects (increased grooming behaviour), and resulted in impaired sexual behaviour, decreased follicle reserve and increased plasma oestradiol concentrations in female offspring.

scholarly journals Maternal care affects male and female offspring working memory and stress reactivity

2007 ◽  
Vol 92 (5) ◽  
pp. 939-950 ◽  
Author(s):  
Cindy K. Barha ◽  
Jodi L. Pawluski ◽  
Liisa A.M. Galea
Keyword(s):  
Working Memory ◽  
Maternal Care ◽  
Stress Reactivity ◽  
Female Offspring ◽  
Male And Female

scholarly journals Developmental Timing of the Effects of Maternal Care on Gene Expression and Epigenetic Regulation of Hormone Receptor Levels in Female Rats

Endocrinology ◽  
2013 ◽  
Vol 154 (11) ◽  
pp. 4340-4351 ◽  
Author(s):  
Catherine Jensen Peña ◽  
Y. Dana Neugut ◽  
Frances A. Champagne
Keyword(s):  
Dna Methylation ◽  
Maternal Behavior ◽  
Maternal Care ◽  
Female Offspring ◽  
Oxytocin Receptor ◽  
Developmental Timing ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Histone 3 ◽  
Cross Fostering

Maternal care experienced during postnatal development has enduring effects on neuroendocrine function and behavior. Previous studies in rats have illustrated the effect of maternal licking/grooming (LG) on hormone receptors and maternal behavior of adult female offspring associated with altered DNA methylation. However, the developmental timing of these effects, which provide insight into the cellular and molecular pathways through which early experience alters later behavior, had not been explored. Here, we demonstrate the developmental emergence of these outcomes and use cross-fostering to identify sensitive periods for these effects. Estrogen receptor (ER)α and ERβ mRNA levels within the medial preoptic area (MPOA) of the hypothalamus were increased by postnatal day (PN)21 in female offspring of high LG dams; LG-associated increases in oxytocin receptor mRNA levels were observed beyond the weaning period. Quantification of ERα-immunoreactivity indicated a high degree of neuroanatomical specificity of LG effects within the MPOA that were observed by PN6. Reduced DNA methylation and histone 3 lysine 9 tri-methylation and increased histone 3 lysine 4 tri-methylation at the ERα gene promoter (Esr1) were detected at PN21 in high LG female offspring. Latency to engage in maternal behavior toward donor pups was significantly shorter among high LG females. Cross-fostering revealed that maternal sensitization and MPOA ERα levels are sensitive to maternal care experienced before but not after PN10. Differential windows of plasticity were identified for ERβ and oxytocin receptor mRNA levels. These studies contribute significantly to our understanding of the molecular, neurobiological, and behavioral pathways through which variation in maternal behavior is transmitted from one generation to the next.

scholarly journals Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. 2909-2915 ◽  
Author(s):  
Frances A. Champagne ◽  
Ian C. G. Weaver ◽  
Josie Diorio ◽  
Sergiy Dymov ◽  
Moshe Szyf ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Maternal Care ◽  
Preoptic Area ◽  
Estrogen Receptor Α ◽  
Female Offspring ◽  
Medial Preoptic Area
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