scholarly journals A Phthalocyanine‐Based Glutathione‐Activated Photosensitizer with a Ferrocenyl Boron Dipyrromethene Dark Quencher for Photodynamic Therapy

ChemPhotoChem ◽  
2019 ◽  
Vol 3 (10) ◽  
pp. 970-970
Author(s):  
Wen‐Jing Shi ◽  
Dennis K. P. Ng ◽  
Shirui Zhao ◽  
Pui‐Chi Lo
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

In vitro and in vivo photocytotoxicity of boron dipyrromethene difluoride for photodynamic therapy

2011 ◽  
Vol 8 (2) ◽  
pp. 191-192
Author(s):  
S.H. Lim ◽  
C. Thivierge ◽  
P. Nowak-Sliwinska ◽  
J. Han ◽  
H. van den Bergh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

scholarly journals A Novel Dicationic Boron Dipyrromethene-based Photosensitizer for Antimicrobial Photodynamic Therapy against Methicillin-Resistant Staphylococcus aureus

2020 ◽  
Vol 28 ◽  
Author(s):  
Priyanga Dharmaratne ◽  
Ligang Yu ◽  
Roy Chi-Hang Wong ◽  
Ben Chun-Lap Chan ◽  
Kit-Man Lau ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Irritation ◽  
Scientific Basis ◽  
Positive Control ◽  
Methicillin Resistant ◽  
Boron Dipyrromethene ◽  
Mrsa Strains

Background: We report herein the synthesis of a novel dicationic boron dipyrromethene derivative (compound 3) which is symmetrically substituted with two trimethylammonium styryl groups. Methods: The antibacterial photodynamic activity of compound 3 was determined against sixteen methicillin-resistant Staphylococcus aureus (MRSA) strains, including four ATCC type strains (ATCC 43300, ATCC BAA-42, ATCC BAA-43, and ATCC BAA-44), two mutant strains [AAC(6’)-APH(2”) and RN4220/pUL5054], and ten non-duplicate clinical strains of hospital- and communityassociated MRSA. Upon light irradiation, the minimum bactericidal concentrations of compound 3 were in the range of 1.56-50 µM against all the sixteen MRSA strains. Interestingly, compound 3 was not only more active than an analogue in which the ammonium groups are not directly connected to the pconjugated system (compound 4), but also showed significantly higher (p < 0.05) antibacterial potency than the clinically approved photosensitizer methylene blue. The skin irritation of compound 3 during topical application was tested on human 3-D skin constructs and proven to be non-irritant in vivo at concentrations below 1.250 mM. In the murine MRSA infected wound study, the colony forming unit reduction of compound 3 + PDT group showed significantly (p < 0.05) higher value (>2.5 log10) compared to other test groups except for the positive control. Conclusion: In conclusion, the present study provides a scientific basis for future development of compound 3 as a potent photosensitizer for photodynamic therapy for MRSA wound infection.

A bioorthogonally activatable photosensitiser for site-specific photodynamic therapy

2020 ◽  
Vol 56 (7) ◽  
pp. 1078-1081 ◽  
Author(s):  
Yimin Zhou ◽  
Roy C. H. Wong ◽  
Gaole Dai ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Alder Reaction ◽  
Diels Alder ◽  
Site Specific ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Boron Dipyrromethene ◽  
Electron Demand

Inverse-electron-demand Diels–Alder reaction of a 1,2,4,5-tetrazine-substituted boron dipyrromethene with a biotin-conjugated trans-cyclooctene results in site-specific activation of the photoactivity of the former photosensitiser.

A Phthalocyanine‐Based Glutathione‐Activated Photosensitizer with a Ferrocenyl Boron Dipyrromethene Dark Quencher for Photodynamic Therapy

ChemPhotoChem ◽  
2019 ◽  
Vol 3 (10) ◽  
pp. 1004-1013 ◽  
Author(s):  
Wen‐Jing Shi ◽  
Dennis K. P. Ng ◽  
Shirui Zhao ◽  
Pui‐Chi Lo
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

In Vitro and In Vivo Photocytotoxicity of Boron Dipyrromethene Derivatives for Photodynamic Therapy

2010 ◽  
Vol 53 (7) ◽  
pp. 2865-2874 ◽  
Author(s):  
Siang Hui Lim ◽  
Cliferson Thivierge ◽  
Patrycja Nowak-Sliwinska ◽  
Junyan Han ◽  
Hubert van den Bergh ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Boron Dipyrromethene

Immobilising hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core–shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy

Nanoscale ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 6499-6512
Author(s):  
Gaole Dai ◽  
Chun Kit K. Choi ◽  
Yimin Zhou ◽  
Qianqian Bai ◽  
Yu Xiao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Core Shell ◽  
Hairpin Dna ◽  
Microrna Detection ◽  
Boron Dipyrromethene

A novel nanosystem based on polydopamine-coated gold nanorods has been designed and fabricated for detection of oncogenic microRNA-21 and microRNA-21-mediated photodynamic therapy.

Ruthenium(II) Conjugates of Boron-Dipyrromethene and Biotin for Targeted Photodynamic Therapy in Red Light

2019 ◽  
Vol 59 (1) ◽  
pp. 913-924
Author(s):  
Subhadeep Paul ◽  
Paramita Kundu ◽  
Utso Bhattacharyya ◽  
Aditya Garai ◽  
Ram Chandra Maji ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Red Light ◽  
Boron Dipyrromethene ◽  
Targeted Photodynamic Therapy
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