Pharmacokinetics of zimelidine in humans ? Plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine

1981 ◽  
Vol 20 (2) ◽  
pp. 135-139 ◽  
Author(s):  
B. L. Love ◽  
R. G. Moore ◽  
J. Thomas ◽  
S. Chaturvedi
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
Intravenous And Oral Administration

Plasma levels and urinary excretion of hexamethylmelamine following oral administration to human subjects with cancer

1968 ◽  
Vol 9 (6) ◽  
pp. 777-782 ◽  
Author(s):  
George T. Bryan ◽  
John F. Worzalla ◽  
Arnold L. Gorske ◽  
G. Ramirez
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
Human Subjects

Plasma Levels and Urinary Excretion of Iodine After Oral Administration of Iohexol in Dogs and Cats

1995 ◽  
Vol 30 (5) ◽  
pp. 296-299 ◽  
Author(s):  
AMALIA AGUT ◽  
FRANCISCO G. LAREDO ◽  
MIGUEL A. SANCHEZ-VALVERDE ◽  
JOSE MURCIANO ◽  
MARIA del CARMEN TOVAR
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Plasma Levels

Pharmacodynamics of [D-Ser (t-Bu), Des-Gly]GnRH ethylamide (Buserelin®) in 6 normal volunteers.

1987 ◽  
Vol 115 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Y. Reznik ◽  
B. P. Winiger ◽  
M. L. Aubert ◽  
P. C. Sizonenko
Keyword(s):  
Urinary Excretion ◽  
Precocious Puberty ◽  
Plasma Levels ◽  
Intranasal Administration ◽  
Cross Reaction ◽  
Disappearance Rate ◽  
Gnrh Analog ◽  
Male Adolescents ◽  
Normal Volunteers ◽  
The Mean

Abstract. The disappearance rate of [D-Ser(t-bu)6,des-Gly10]GnRH ethylamide (Buserelin®, HOE 766) was studied in plasma and urine after intranasal (300 μg) or sc (10 μg/kg) administration. A radioimmunoassay for HOE 766 was developed using 125I[D-Trp6,Des-Gly10]GnRH ethylamide as tracer and an antiserum raised against HOE 766. Cross-reaction with native GnRH was only 1.7%. Sensitivity was 1 pg/tube. In 6 male adolescents, the mean plasma HOE 766 concentration (± sem) was 0.46 ± 0.08, 0.50 ± 0.10, 0.28 ± 0.04, 0.24 ± 0.04, 0.13 ± 0.03, and 0.08 ± 0.02 μg/l 30, 60, 90, 120 and 180 min after the intranasal administration, respectively. Concomitant urinary excretion of HOE 766-like material was 9.43 ± 1.96 μg/4 h. There was a good correlation between integrated plasma levels and urinary excretion (r = 0.92). In the same 6 volunteers, the plasma HOE 766 levels were 21.2 ± 3.0, 25.9 ± 0.8, 21.2 ± 0.9, 17.1 ± 0.7, 12.8 ± 1.1, 8.9 ± 0.4, and 5.9 ± 0.8 μg/l 20, 40, 60, 90, 120, 180 and 240 min after sc injection, respectively. The mean urinary excretion was 543 ± 61 μg/4 h. In two girls with precocious puberty treated during 12 to 15 months with intranasal administration of HOE 766, urinary excretion of HOE 766-like material was shown to correlate well with the degree of inhibition of plasma 17β-E2and of plasma LH and FSH responses to a GnRH challenge. Thus, monitoring of HOE 766 in urine appears to be helpful for evaluating of intranasal therapy with a GnRH analog in precocious puberty.

Plasma levels and absorption of methaqualone after oral administration to man

1972 ◽  
Vol 13 (5part1) ◽  
pp. 719-723 ◽  
Author(s):  
Robert N. Morris ◽  
Gwendolyn A. Gunderson ◽  
Steven W. Babcock ◽  
John F. Zaroslinski
Keyword(s):  
Oral Administration ◽  
Plasma Levels
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