Controlled Release of Reactive Gases: A Tale of Taming Carbon Monoxide

ChemPlusChem ◽  
2020 ◽  
Vol 85 (7) ◽  
pp. 1529-1533
Author(s):  
Anne K. Ravn ◽  
Martin B. Johansen ◽  
Troels Skrydstrup
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Reactive Gases

scholarly journals Controlled Release of Carbon Monoxide from a Pseudo Electron-Deficient Organometallic Complex

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 15623-15627 ◽  
Author(s):  
Anaïs Pitto-Barry ◽  
Nicolas P. E. Barry
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Organometallic Complex

scholarly journals A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Li ◽  
Zeming Liu ◽  
Weng Zeng ◽  
Ziqi Wang ◽  
Chunping Liu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Tumor Site ◽  
Co Poisoning ◽  
Chemotherapy Agent ◽  
Manganese Carbonyl ◽  
Co Gas

Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H2O2. MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. Both in vitro and in vivo experiments indicate that the ZCM system is both safe and has excellent tumor inhibition properties. ZCM is a novel system for CO controlled release, with significant potential to improve future cancer therapy.

scholarly journals Historical (1850–2000) gridded anthropogenic and biomass burning emissions of reactive gases and aerosols: methodology and application

2010 ◽  
Vol 10 (2) ◽  
pp. 4963-5019 ◽  
Author(s):  
J.-F. Lamarque ◽  
T. C. Bond ◽  
V. Eyring ◽  
C. Granier ◽  
A. Heil ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Climate Models ◽  
Climate Model ◽  
Historical Period ◽  
Term Trend ◽  
Model Simulations ◽  
Reactive Gases ◽  
Long Term Trend ◽  
Good Agreement

Abstract. We present and discuss a new dataset of gridded emissions covering the historical period (1850–2000) in decadal increments at a horizontal resolution of 0.5° in latitude and longitude. The primary purpose of this inventory is to provide consistent gridded emissions of reactive gases and aerosols for use in chemistry model simulations needed by climate models for the Climate Model Intercomparison Program #5 (CMIP5) in support of the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5). Our best estimate for the year 2000 inventory represents a combination of existing regional and global inventories to capture the best information available at this point; 40 regions and 12 sectors are used to combine the various sources. The historical reconstruction of each emitted compound, for each region and sector, is then forced to agree with our 2000 estimate, ensuring continuity between past and 2000 emissions. Simulations from two chemistry-climate models is used to test the ability of the emission dataset described here to capture long-term changes in atmospheric ozone, carbon monoxide and aerosol distributions. The simulated long-term change in the Northern mid-latitudes surface and mid-troposphere ozone is not quite as rapid as observed. However, stations outside this latitude band show much better agreement in both present-day and long-term trend. The model simulations indicate that the concentration of carbon monoxide is underestimated at the Mace Head station; however, the long-term trend over the limited observational period seems to be reasonably well captured. The simulated sulfate and black carbon deposition over Greenland is in very good agreement with the ice-core observations spanning the simulation period. Finally, aerosol optical depth and additional aerosol diagnostics are shown to be in good agreement with previously published estimates and observations.

scholarly journals Data assimilation of satellite-retrieved ozone, carbon monoxide and nitrogen dioxide with ECMWF's Composition-IFS

2015 ◽  
Vol 15 (9) ◽  
pp. 5275-5303 ◽  
Author(s):  
A. Inness ◽  
A.-M. Blechschmidt ◽  
I. Bouarar ◽  
S. Chabrillat ◽  
M. Crepulja ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Data Assimilation ◽  
Nitrogen Dioxide ◽  
Initial Conditions ◽  
Stratospheric Ozone ◽  
Lower Troposphere ◽  
Atmospheric Composition ◽  
Reactive Gases ◽  
The Impact ◽  
Total Column

Abstract. Daily global analyses and 5-day forecasts are generated in the context of the European Monitoring Atmospheric Composition and Climate (MACC) project using an extended version of the Integrated Forecasting System (IFS) of the European Centre for Medium-Range Weather Forecasts (ECMWF). The IFS now includes modules for chemistry, deposition and emission of reactive gases, aerosols, and greenhouse gases, and the 4-dimensional variational data assimilation scheme makes use of multiple satellite observations of atmospheric composition in addition to meteorological observations. This paper describes the data assimilation setup of the new Composition-IFS (C-IFS) with respect to reactive gases and validates analysis fields of ozone (O3), carbon monoxide (CO), and nitrogen dioxide (NO2) for the year 2008 against independent observations and a control run without data assimilation. The largest improvement in CO by assimilation of Measurements of Pollution in the Troposphere (MOPITT) CO columns is seen in the lower troposphere of the Northern Hemisphere (NH) extratropics during winter, and during the South African biomass-burning season. The assimilation of several O3 total column and stratospheric profile retrievals greatly improves the total column, stratospheric and upper tropospheric O3 analysis fields relative to the control run. The impact on lower tropospheric ozone, which comes from the residual of the total column and stratospheric profile O3 data, is smaller, but nevertheless there is some improvement particularly in the NH during winter and spring. The impact of the assimilation of tropospheric NO2 columns from the Ozone Monitoring Instrument (OMI) is small because of the short lifetime of NO2, suggesting that NO2 observations would be better used to adjust emissions instead of initial conditions. The results further indicate that the quality of the tropospheric analyses and of the stratospheric ozone analysis obtained with the C-IFS system has improved compared to the previous "coupled" model system of MACC.

New photo-CORMs: Deeply-coloured biocompatible rhenium complexes for the controlled release of carbon monoxide

2015 ◽  
Vol 435 ◽  
pp. 174-177 ◽  
Author(s):  
Elham Kianfar ◽  
Christine Schäfer ◽  
Mohammad Reza Lornejad-Schäfer ◽  
Engelbert Portenkirchner ◽  
Günther Knör
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Rhenium Complexes

scholarly journals Historical (1850–2000) gridded anthropogenic and biomass burning emissions of reactive gases and aerosols: methodology and application

2010 ◽  
Vol 10 (15) ◽  
pp. 7017-7039 ◽  
Author(s):  
J.-F. Lamarque ◽  
T. C. Bond ◽  
V. Eyring ◽  
C. Granier ◽  
A. Heil ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Climate Models ◽  
Climate Model ◽  
Historical Period ◽  
Term Trend ◽  
Model Simulations ◽  
Reactive Gases ◽  
Long Term Trend ◽  
Good Agreement

Abstract. We present and discuss a new dataset of gridded emissions covering the historical period (1850–2000) in decadal increments at a horizontal resolution of 0.5° in latitude and longitude. The primary purpose of this inventory is to provide consistent gridded emissions of reactive gases and aerosols for use in chemistry model simulations needed by climate models for the Climate Model Intercomparison Program #5 (CMIP5) in support of the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment report (AR5). Our best estimate for the year 2000 inventory represents a combination of existing regional and global inventories to capture the best information available at this point; 40 regions and 12 sectors are used to combine the various sources. The historical reconstruction of each emitted compound, for each region and sector, is then forced to agree with our 2000 estimate, ensuring continuity between past and 2000 emissions. Simulations from two chemistry-climate models are used to test the ability of the emission dataset described here to capture long-term changes in atmospheric ozone, carbon monoxide and aerosol distributions. The simulated long-term change in the Northern mid-latitudes surface and mid-troposphere ozone is not quite as rapid as observed. However, stations outside this latitude band show much better agreement in both present-day and long-term trend. The model simulations indicate that the concentration of carbon monoxide is underestimated at the Mace Head station; however, the long-term trend over the limited observational period seems to be reasonably well captured. The simulated sulfate and black carbon deposition over Greenland is in very good agreement with the ice-core observations spanning the simulation period. Finally, aerosol optical depth and additional aerosol diagnostics are shown to be in good agreement with previously published estimates and observations.

scholarly journals Carbon monoxide – physiology, detection and controlled release

2014 ◽  
Vol 50 (28) ◽  
pp. 3644-3660 ◽  
Author(s):  
Stefan H. Heinemann ◽  
Toshinori Hoshi ◽  
Matthias Westerhausen ◽  
Alexander Schiller
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release

Effector systems, sensing and controlled release of the biosignaling molecule carbon monoxide are featured.

Carbon Monoxide and Its Controlled Release: Therapeutic Application, Detection, and Development of Carbon Monoxide Releasing Molecules (CORMs)

2017 ◽  
Vol 61 (7) ◽  
pp. 2611-2635 ◽  
Author(s):  
Ken Ling ◽  
Fang Men ◽  
Wei-Ci Wang ◽  
Ya-Qun Zhou ◽  
Hao-Wen Zhang ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Therapeutic Application

ChemInform Abstract: Carbon Monoxide - Physiology, Detection and Controlled Release

ChemInform ◽  
2014 ◽  
Vol 45 (21) ◽  
pp. no-no
Author(s):  
Stefan H. Heinemann ◽  
Toshinori Hoshi ◽  
Matthias Westerhausen ◽  
Alexander Schiller
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release

scholarly journals Controlled Release of Carbon Monoxide Based on Nanomaterials and Their Biomedical Applications

2019 ◽  
Vol 77 (5) ◽  
pp. 406
Author(s):  
Xiaolei Zhang ◽  
Gan Tian ◽  
Xia Zhang ◽  
Qing Wang ◽  
Zhanjun Gu
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Biomedical Applications
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