scholarly journals Controlled Release of Carbon Monoxide Based on Nanomaterials and Their Biomedical Applications

2019 ◽  
Vol 77 (5) ◽  
pp. 406
Author(s):  
Xiaolei Zhang ◽  
Gan Tian ◽  
Xia Zhang ◽  
Qing Wang ◽  
Zhanjun Gu
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Biomedical Applications

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals Synthesis and Evaluation of AlgNa-g-poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

2021 ◽  
Vol 22 (11) ◽  
pp. 5730
Author(s):  
Jomarien García-Couce ◽  
Marioly Vernhes ◽  
Nancy Bada ◽  
Lissette Agüero ◽  
Oscar Valdés ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Controlled Release ◽  
Biomedical Applications ◽  
Release Kinetics ◽  
Cell Types ◽  
Tissue Engineering Scaffolds ◽  
Almost All ◽  
Scanning Electron

Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using a different concentration of the components. The hydrogels were characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, and a swelling degree. Betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at a different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner for up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay showed that almost all hydrogels are cytocompatibles and an increase of proliferation in both cell types after one week of incubation was observed by the Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics, and biocompatibility.

scholarly journals Controlled Release of Carbon Monoxide from a Pseudo Electron-Deficient Organometallic Complex

ACS Omega ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 15623-15627 ◽  
Author(s):  
Anaïs Pitto-Barry ◽  
Nicolas P. E. Barry
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Organometallic Complex

scholarly journals Controlled-release formulation of perindopril erbumine loaded PEG-coated magnetite nanoparticles for biomedical applications

2014 ◽  
Vol 49 (24) ◽  
pp. 8487-8497 ◽  
Author(s):  
Dena Dorniani ◽  
Aminu Umar Kura ◽  
Mohd Zobir Bin Hussein ◽  
Sharida Fakurazi ◽  
Abdul Halim Shaari ◽  
...  
Keyword(s):  
Controlled Release ◽  
Magnetite Nanoparticles ◽  
Biomedical Applications ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Perindopril Erbumine

scholarly journals Generation of multilayered structures for biomedical applications using a novel tri-needle coaxial device and electrohydrodynamic flow

2008 ◽  
Vol 5 (27) ◽  
pp. 1255-1261 ◽  
Author(s):  
Z Ahmad ◽  
H.B Zhang ◽  
U Farook ◽  
M Edirisinghe ◽  
E Stride ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Biomedical Engineering ◽  
Biomedical Applications ◽  
Short Communication ◽  
Multilayered Structures ◽  
Electrohydrodynamic Flow ◽  
Novel Device ◽  
Flow Through ◽  
Controlled Flow

In this short communication, we describe the scope and flexibility of using a novel device containing three coaxially arranged needles to form a variety of novel morphologies. Different combinations of materials are subjected to controlled flow through the device under the influence of an applied electric field. The resulting electrohydrodynamic flow allows us to prepare double-layered bubbles, porous encapsulated threads and nanocapsules containing three layers. The ability to process such multilayered structures is very significant for biomedical engineering applications, for example, generating capsules for drug delivery, which can provide multistage controlled release.

scholarly journals A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Yang Li ◽  
Zeming Liu ◽  
Weng Zeng ◽  
Ziqi Wang ◽  
Chunping Liu ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Tumor Microenvironment ◽  
Tumor Site ◽  
Co Poisoning ◽  
Chemotherapy Agent ◽  
Manganese Carbonyl ◽  
Co Gas

Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intravenous injection, ZCM gradually accumulates in cancerous tissues, decomposing in the acidic tumor microenvironment, releasing CPT and MnCO. CPT acts as a chemotherapy agent destroying tumors and producing copious H2O2. MnCO can react with the H2O2 to generate CO, powerfully damaging the tumor. Both in vitro and in vivo experiments indicate that the ZCM system is both safe and has excellent tumor inhibition properties. ZCM is a novel system for CO controlled release, with significant potential to improve future cancer therapy.

Resorbable hollow phosphate glass fibres as controlled release systems for biomedical applications

2013 ◽  
Vol 99 ◽  
pp. 125-127 ◽  
Author(s):  
G. Novajra ◽  
J. Lousteau ◽  
D. Milanese ◽  
C. Vitale-Brovarone
Keyword(s):  
Controlled Release ◽  
Phosphate Glass ◽  
Biomedical Applications ◽  
Glass Fibres

New photo-CORMs: Deeply-coloured biocompatible rhenium complexes for the controlled release of carbon monoxide

2015 ◽  
Vol 435 ◽  
pp. 174-177 ◽  
Author(s):  
Elham Kianfar ◽  
Christine Schäfer ◽  
Mohammad Reza Lornejad-Schäfer ◽  
Engelbert Portenkirchner ◽  
Günther Knör
Keyword(s):  
Carbon Monoxide ◽  
Controlled Release ◽  
Rhenium Complexes
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