scholarly journals Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high-resolution DNA flow cytometry

Cancer ◽  
2011 ◽  
Vol 117 (22) ◽  
pp. 5052-5057 ◽  
Author(s):  
Monica Pentenero ◽  
Alessandra Donadini ◽  
Emanuela Di Nallo ◽  
Massimo Maffei ◽  
Roberto Marino ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
High Resolution ◽  
Squamous Cell ◽  
Chromosomal Instability ◽  
Squamous Cell Carcinomas ◽  
Dna Flow Cytometry

scholarly journals Chromosomal Composition of Aneuploid Clones with Different DNA Contents in Head and Neck Squamous Cell Carcinomas as Determined by Combined Flow Cytometry and FluorescenceIn SituHybridization

2000 ◽  
Vol 20 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Joerg Hemmer ◽  
Carmen Hauser
Keyword(s):  
Flow Cytometry ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Dna Probes ◽  
Chromosome 17 ◽  
Cell Populations ◽  
Dna Flow Cytometry ◽  
Wide Range ◽  
Dna Contents

Studies with DNA flow cytometry (FCM) have shown that DNA contents of aneuploid tumour clones vary in a wide range. The aim of this study was to analyse whether homologous chromosomal changes exist despite the individual differences that may be of general relevance for the development of gross aneuploidy in squamous cell carcinomas of the head and neck. Fluorescencein situhybridization (FISH) with 13 centromere‐specific DNA probes was applied to 3 diploid and 11 aneuploid tumours with DNA indices ranging between 0.8 and 2.2. Disomic and monosomic cell populations were prevalent findings in DNA‐diploid tumours. Polysomies were common in aneuploid tumours. Different degrees of aneusomy for identical chromosomes were recurrent features in aneuploid tumours. FISH signal heterogeneity was identified for all chromosomes. The mean number of aneusomic cell populations identified for DNA‐aneuploid tumours ranged between 1.6 for chromosome 17 and 3.1 for chromosome 3. Inconsistencies between FISH and FCM data may indicate that centromere‐specific DNA probes identify gains and losses of marker DNA due to complex karyotypic rearrangements rather than absolute changes in chromosome numbers. Overall, there was no evidence of the critical involvement of particular chromosomes in the development of different DNA contents.

Relationship between histologic features, DNA flow cytometry, and clinical behavior of squamous cell carcinomas of the larynx

Cancer ◽  
1991 ◽  
Vol 67 (1) ◽  
pp. 141-149 ◽  
Author(s):  
Savino Ruá ◽  
Alberto Comino ◽  
Adriana Fruttero ◽  
Giovanni Cera ◽  
Carlo Semeria ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Dna Flow Cytometry ◽  
Clinical Behavior

Prognostic Value of Histopathologic Parameters and DNA Flow Cytometry in Squamous Cell Carcinoma of the Pyriform Sinus

1998 ◽  
Vol 108 (2) ◽  
pp. 269-272 ◽  
Author(s):  
Adolfo Del Valle-Zapico ◽  
Fidel Fernández Fernández ◽  
Antonio Rubio Suárez ◽  
Carmelo Morales Angulo ◽  
Julio Rama Quintela
Keyword(s):  
Flow Cytometry ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Pyriform Sinus ◽  
Dna Flow Cytometry

High resolution DNA flow cytometry of boar sperm cells in identification of boars carrying cytogenetic aberrations

2004 ◽  
Vol 62 (3-4) ◽  
pp. 501-511
Author(s):  
Jacob Larsen ◽  
Knud Christensen ◽  
Jørgen K Larsen ◽  
Peter Østrup Jensen ◽  
Ingemar Gustavsson ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
High Resolution ◽  
Dna Flow Cytometry ◽  
Sperm Cells ◽  
Cytogenetic Aberrations ◽  
Boar Sperm
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